ID A0A2I2A3P8_9GAMM Unreviewed; 557 AA.
AC A0A2I2A3P8;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Sodium:proton antiporter {ECO:0000313|EMBL:PLA74015.1};
GN ORFNames=CYQ88_07890 {ECO:0000313|EMBL:PLA74015.1};
OS Hydrogenovibrio sp. SC-1.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales;
OC Piscirickettsiaceae; Hydrogenovibrio.
OX NCBI_TaxID=2065820 {ECO:0000313|EMBL:PLA74015.1, ECO:0000313|Proteomes:UP000234529};
RN [1] {ECO:0000313|Proteomes:UP000234529}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC-1 {ECO:0000313|Proteomes:UP000234529};
RA Barco R.A., Emerson D.;
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PLA74015.1}.
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DR EMBL; PKGB01000013; PLA74015.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2I2A3P8; -.
DR OrthoDB; 9774146at2; -.
DR Proteomes; UP000234529; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015385; F:sodium:proton antiporter activity; IEA:InterPro.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 6.10.140.1330; -; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR018422; Cation/H_exchanger_CPA1.
DR InterPro; IPR000160; GGDEF_dom.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR PANTHER; PTHR10110; SODIUM/HYDROGEN EXCHANGER; 1.
DR PANTHER; PTHR10110:SF86; SODIUM_HYDROGEN EXCHANGER 7; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR SMART; SM00267; GGDEF; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
PE 4: Predicted;
KW Antiport {ECO:0000256|ARBA:ARBA00022449};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000234529};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 53..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 81..103
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 109..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 155..174
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 186..205
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 212..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 234..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 288..311
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 317..338
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 345..364
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 376..399
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 419..556
FT /note="GGDEF"
FT /evidence="ECO:0000259|SMART:SM00267"
SQ SEQUENCE 557 AA; 62630 MW; EF515B0365769C4E CRC64;
MLLLFTLILL VVLLSRFFEQ SFKIPFALTA IVSAYLANMV FDLSAFGEHF PDIVYLMLPI
ILIPDVLGVS RSELRHNLSA IIYLSVFAVL ISIALAIIAT LLLTPEQQFT MGMLLALFTP
LMATDVVSVS AIFAKFKLPE KLKLYAEGES LFNDITAMII FFFIALPLIE GQTLQTSSLH
LVLGKLFIES ILIGLTAGML GYYAFKFFTD NVEQFLTLYI MASLAFIVGE HLQVSGMLGV
VVTILLFKYL FDKEGQYKKI NTSVLTQFLN TESTSDGNFR AYRKEAHYLG LFANGVIFIA
IANVVDLNLL WQYHLPILVV FALTTLIRFL VVTPLIWWKI HPFRWAGVLT FAGMKGGLAI
IMVFALPDNF SYKEAFMSIV VGVVILSMFV NTALLVLFLR LNNEAFALDK ADDHNTLSGE
EAKQQLKKLL QKDAQSQAYN ALVFEELIEK EMARSQRYHA PFALLAFESD KADLTGQIIL
PMLRKSDYFG RLNQQRFCIL ATHSDIDSAM IIAQKLRKRL ESKQVSIAEY TPGDNLELLY
EKLEAGFKTD KAIAIEV
//
