ID A0A2I2GBH8_9EURO Unreviewed; 1903 AA.
AC A0A2I2GBH8;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 03-MAY-2023, entry version 19.
DE RecName: Full=1,3-beta-glucan synthase {ECO:0000256|ARBA:ARBA00012589};
DE EC=2.4.1.34 {ECO:0000256|ARBA:ARBA00012589};
DE AltName: Full=1,3-beta-D-glucan-UDP glucosyltransferase {ECO:0000256|ARBA:ARBA00031935};
GN ORFNames=P170DRAFT_354449 {ECO:0000313|EMBL:PLB50233.1};
OS Aspergillus steynii IBT 23096.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=1392250 {ECO:0000313|EMBL:PLB50233.1, ECO:0000313|Proteomes:UP000234275};
RN [1] {ECO:0000313|EMBL:PLB50233.1, ECO:0000313|Proteomes:UP000234275}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 23096 {ECO:0000313|EMBL:PLB50233.1,
RC ECO:0000313|Proteomes:UP000234275};
RG DOE Joint Genome Institute;
RA Vesth T.C., Nybo J., Theobald S., Brandl J., Frisvad J.C., Nielsen K.F.,
RA Lyhne E.K., Kogle M.E., Kuo A., Riley R., Clum A., Nolan M., Lipzen A.,
RA Salamov A., Henrissat B., Wiebenga A., De Vries R.P., Grigoriev I.V.,
RA Mortensen U.H., Andersen M.R., Baker S.E.;
RT "The genomes of Aspergillus section Nigri reveals drivers in fungal
RT speciation.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[(1->3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1->3)-
CC beta-D-glucosyl](n+1) + H(+) + UDP; Xref=Rhea:RHEA:21476, Rhea:RHEA-
CC COMP:11146, Rhea:RHEA-COMP:14303, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:37671, ChEBI:CHEBI:58223, ChEBI:CHEBI:58885; EC=2.4.1.34;
CC Evidence={ECO:0000256|ARBA:ARBA00000192};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 48 family.
CC {ECO:0000256|ARBA:ARBA00009040}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PLB50233.1}.
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DR EMBL; MSFO01000003; PLB50233.1; -; Genomic_DNA.
DR STRING; 1392250.A0A2I2GBH8; -.
DR VEuPathDB; FungiDB:P170DRAFT_354449; -.
DR OrthoDB; 354539at2759; -.
DR Proteomes; UP000234275; Unassembled WGS sequence.
DR GO; GO:0000148; C:1,3-beta-D-glucan synthase complex; IEA:InterPro.
DR GO; GO:0003843; F:1,3-beta-D-glucan synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0006075; P:(1->3)-beta-D-glucan biosynthetic process; IEA:InterPro.
DR InterPro; IPR026899; FKS1-like_dom1.
DR InterPro; IPR003440; Glyco_trans_48.
DR PANTHER; PTHR12741:SF29; 1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED; 1.
DR PANTHER; PTHR12741; LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1; 1.
DR Pfam; PF14288; FKS1_dom1; 1.
DR Pfam; PF02364; Glucan_synthase; 1.
DR SMART; SM01205; FKS1_dom1; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000234275};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 482..501
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 521..542
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 562..582
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 594..619
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 652..674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1329..1348
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1386..1405
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1494..1516
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1587..1608
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1628..1654
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1666..1690
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1696..1715
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1763..1789
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1827..1847
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 329..441
FT /note="1,3-beta-glucan synthase component FKS1-like"
FT /evidence="ECO:0000259|SMART:SM01205"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 73..100
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..100
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1903 AA; 217806 MW; 87A83D187D79DEF9 CRC64;
MSGHPGGGHY DDGYGHNGHG DSYYQDEHAQ GYYDTHDYGD GYYDRGGYYG ADNGAYQQDG
GYYDAGHHDD YYGDQYYDNA GQGGRGRRRG DSEEDSETFS DFTMRSETAR AADMDYYGRG
DERYNSYADS QYGRGYGGYR PPSSQISYGA NRSSGASTPV YGMDYGNALP AGQRSREPYP
AWASDAQIPV SKEEIEDIFI DLVNKFGFQR DSMRNMYDHL MTQLDSRASR MTPNQALLSL
HADYIGGDNA NYRRWYFAAH LDLDDAVGFA NMKLGKADRK TRKARKAAQK AAEQNPENVD
ETLESLQGDN SLEAAEYRWK TRMNRMSQHD RVRQLALFLC CWGEANQVRY LPECLCFIFK
CADDYYTSPE CQNRVEPVEE GTYLNDIITP LYQYCRDQGY EIVDGKYVKR ERDHNQIIGY
DDMNQLFWYP EGIERIGFED KTRLVDVPPA ERWVKLKDVD WKKAFFKTYK ETRSWFHMVT
NFNRIWVIHL GSFWFFTAYN APTLYTHNYQ QQLNNKPPGA YYWSAVGFGG ALCAFIQIFA
TIMEWMYVPR LWAGAQHLTK RLMFLLLVFI INLAPGVFVF GFSKKVDNNT IPLVIGIVHF
FIALATFFFF AVMPLGGLFG SYLKKHGRQY VASQTFTASF PRLTGNDMWM SYGLWVCVFG
AKLAESYFFL TLSFKDPIRI LSPMKLRQCA GVKYIPNDLC HAQPQILLGL MFFMDLTLFF
LDSYLWYIIC NTVFSVARSF YLGVSIWSPW RNIFSRLPKR IYSKVLATTD MEIKYKPKVL
ISQVWNAIII SMYREHLLAI DHVQKLLYHQ VPSEQEGKRT LRAPTFFVSQ EDQSFKTEFF
PSGSEAERRI SFFAQSLSTP MPEPLPVDNM PAFTVLIPHY SEKILLSLRE IIREDEPYSR
VTLLEYLKQL HPHEWDCFVK DTKILADETS QFNGEYEKSE KDVAKSKIDD LPFYCIGFKS
AAPEYTLRTR IWSSLRSQTL YRTVSGFMNY SRAIKLLYRV ENPEVVQMFG GNSEKLEREL
ERMARRKFKI CVSMQRYAKF NKEERENTEF LLRAYPDLQI AYLDEEPPVN EGDEPRLYSA
LIDGHCELLD NGMRKPKFRI QLSGNPILGD GKSDNQNHSI IFYRGEYIQV IDANQDNYLE
ECLKIRSVLA EFEELTTDNV SPYTPGIPST STNPVAILGA REYIFSESVG VLGDVAASKE
QTFGTLFART LAQIGGKLHY GHPDFLNGIF MCTRGGISKA QKGLHLNEDI YAGMMALTRG
GRIKHCEYFQ CGKGRDLGFG SILNFTTKIG TGMGEQMLSR EYYYLGTQLP LDRFLSFYYA
HPGFHLNNMF IMLSVQMFMI VLVNLGALKH ETITCKYNPD VPITDPLRPT FCANLTPIMD
WVNRCIISIF IVFFISFVPL AVQELTERGV WRMAMRLAKH FGSFSFMFEV FVCQIYANAV
HQNLSFGGAR YIGTGRGFAT ARIPFGVLYS RFAGPSIYAG ARSLLMLLFS TSTVWSAALI
WFWVSLLALC ISPFLFNPHQ FAWNDFFIDY RDYLRWLSRG NSRSHASSWI AFCRLSRTRI
TGYKRKLLGV PSEKGSGDVP RARITNIFFS EIVAPLVHVA VTLVPFLYIN SRTGVSNDNE
NDSYNALIRI GIVALGPIGV NAGVAGAFFG MACCMGPIFS MCCKKFGAVL AAIAHAIAVI
VLLIIFEVMF FLEHWSWPRC IMGMIAMAAI QRFIYKLIIA LTLTREFKHD QSNIAWWTGK
WYNMGWHSMT QPGREFLCKI TELGYFAGDF VLGHLILFIM LPALCIPYVD KFHSIILFWL
RPSRQIRPPI YSLKQSKLRK RRVVRFAIMY FTMLVIFLVL LIAPLVVRKM GIIKQDMIDK
FPEALLQPLD GGGANNDTTS KYTGSGLPHG FSAWVPPSAS ATS
//
