ID A0A2I2GFN5_9EURO Unreviewed; 669 AA.
AC A0A2I2GFN5;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 03-MAY-2023, entry version 19.
DE RecName: Full=Eukaryotic translation initiation factor 2A {ECO:0000256|ARBA:ARBA00013819, ECO:0000256|PIRNR:PIRNR017222};
DE Short=eIF-2A {ECO:0000256|PIRNR:PIRNR017222};
GN ORFNames=P170DRAFT_471625 {ECO:0000313|EMBL:PLB51700.1};
OS Aspergillus steynii IBT 23096.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=1392250 {ECO:0000313|EMBL:PLB51700.1, ECO:0000313|Proteomes:UP000234275};
RN [1] {ECO:0000313|EMBL:PLB51700.1, ECO:0000313|Proteomes:UP000234275}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=IBT 23096 {ECO:0000313|EMBL:PLB51700.1,
RC ECO:0000313|Proteomes:UP000234275};
RG DOE Joint Genome Institute;
RA Vesth T.C., Nybo J., Theobald S., Brandl J., Frisvad J.C., Nielsen K.F.,
RA Lyhne E.K., Kogle M.E., Kuo A., Riley R., Clum A., Nolan M., Lipzen A.,
RA Salamov A., Henrissat B., Wiebenga A., De Vries R.P., Grigoriev I.V.,
RA Mortensen U.H., Andersen M.R., Baker S.E.;
RT "The genomes of Aspergillus section Nigri reveals drivers in fungal
RT speciation.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions in the early steps of protein synthesis of a small
CC number of specific mRNAs. Acts by directing the binding of methionyl-
CC tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it
CC binds methionyl-tRNAi to 40S subunits in a codon-dependent manner,
CC whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a
CC GTP-dependent manner. {ECO:0000256|PIRNR:PIRNR017222}.
CC -!- SIMILARITY: Belongs to the WD repeat EIF2A family.
CC {ECO:0000256|ARBA:ARBA00009573, ECO:0000256|PIRNR:PIRNR017222}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PLB51700.1}.
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DR EMBL; MSFO01000002; PLB51700.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2I2GFN5; -.
DR STRING; 1392250.A0A2I2GFN5; -.
DR VEuPathDB; FungiDB:P170DRAFT_471625; -.
DR OrthoDB; 22264at2759; -.
DR Proteomes; UP000234275; Unassembled WGS sequence.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011387; TIF2A.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13227; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR PANTHER; PTHR13227:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR Pfam; PF08662; eIF2A; 1.
DR PIRSF; PIRSF017222; eIF2A; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000256|PIRNR:PIRNR017222};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|PIRNR:PIRNR017222};
KW Reference proteome {ECO:0000313|Proteomes:UP000234275};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845,
KW ECO:0000256|PIRNR:PIRNR017222}.
FT DOMAIN 218..412
FT /note="Translation initiation factor beta propellor-like"
FT /evidence="ECO:0000259|Pfam:PF08662"
FT REGION 479..599
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 557..581
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 669 AA; 72491 MW; 87C2515F6260E42B CRC64;
MAAPTQLAYR TVKGIGIFDA APVYGPLSGF EKPEGNLRCS AYSPCGRYFA WASPDKVTIV
DPSVGHAITS IPADNVFELG FSPLGTYLIT WQRPTKDANG DAVKNLKVWK VVETPADSNG
DEHTIVGSYV QKSQTGWNLQ YTSDERHCAR VVTNEVQFYE SDNLSKVWNK LRVEGVSDFA
LSPGKNQAVA VFIPERKGQP AAVKVFMVPQ FGAPVSQKTF FKGDKVQLKW NASGNTLIVL
AQTDVDRSGK SYYGETTLYL LGASGGFDSR VDLDKEGPIH DVTWSPNSKE FGVVYGYMPA
KTTIFNFRGV PQHSFPLAPR NTIQFSPHGR FVLVAGFGNL AGQMDLYDLE KNYFKITTVE
ASNASVCEWS PDGQFILTAT TSPRLRVDNG IRLWHVSGAL MYNEEMTELY DVSWRPQSTT
QHPLSDPFNP LPAPHPSAAA YLSTRKAPVK PAGAYRPPGA RGQTTPLAFK REDQGGAAYV
RDGANGGSSL NGFGKPRRRD VPGAEEFLPP GAAPGGGVAL PPGADQPEKL SKSAARNKKK
REAKKISPNG EDGEAAPPAR SPDRRGDKGH ENNRSKANHA ERKNANNQTN GAAAPAKAAA
PVNVNVADDA AGAPTAQEKK IRGLLKKIRA IDELKMRLAG GEKLEDTQMK KIQTEESVRK
ELDSLGYTG
//
