ID A0A2I2KNZ0_9ACTN Unreviewed; 462 AA.
AC A0A2I2KNZ0;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=diacylglycerol O-acyltransferase {ECO:0000256|ARBA:ARBA00013244};
DE EC=2.3.1.20 {ECO:0000256|ARBA:ARBA00013244};
GN ORFNames=FRACA_1870009 {ECO:0000313|EMBL:SNQ47393.1};
OS Frankia canadensis.
OC Bacteria; Actinomycetota; Actinomycetes; Frankiales; Frankiaceae; Frankia.
OX NCBI_TaxID=1836972 {ECO:0000313|EMBL:SNQ47393.1, ECO:0000313|Proteomes:UP000234331};
RN [1] {ECO:0000313|EMBL:SNQ47393.1, ECO:0000313|Proteomes:UP000234331}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FRACA_ARgP5 {ECO:0000313|EMBL:SNQ47393.1};
RA Kim H.J., Triplett B.A.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycerol + an acyl-CoA = a triacyl-sn-glycerol
CC + CoA; Xref=Rhea:RHEA:10868, ChEBI:CHEBI:17815, ChEBI:CHEBI:57287,
CC ChEBI:CHEBI:58342, ChEBI:CHEBI:64615; EC=2.3.1.20;
CC Evidence={ECO:0000256|ARBA:ARBA00001039};
CC -!- PATHWAY: Glycerolipid metabolism; triacylglycerol biosynthesis.
CC {ECO:0000256|ARBA:ARBA00004771}.
CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC -!- SIMILARITY: Belongs to the long-chain O-acyltransferase family.
CC {ECO:0000256|ARBA:ARBA00009587}.
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DR EMBL; FZMO01000098; SNQ47393.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2I2KNZ0; -.
DR OrthoDB; 4671961at2; -.
DR UniPathway; UPA00282; -.
DR Proteomes; UP000234331; Unassembled WGS sequence.
DR GO; GO:0004144; F:diacylglycerol O-acyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006071; P:glycerol metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0019432; P:triglyceride biosynthetic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR045034; O-acyltransferase_WSD1-like.
DR InterPro; IPR004255; O-acyltransferase_WSD1_N.
DR PANTHER; PTHR31650:SF1; DIACYGLYCEROL O-ACYLTRANSFERASE TGS4-RELATED; 1.
DR PANTHER; PTHR31650; O-ACYLTRANSFERASE (WSD1-LIKE) FAMILY PROTEIN; 1.
DR Pfam; PF03007; WS_DGAT_cat; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000313|EMBL:SNQ47393.1};
KW Glycerol metabolism {ECO:0000256|ARBA:ARBA00022798};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000234331};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:SNQ47393.1}.
FT DOMAIN 43..207
FT /note="O-acyltransferase WSD1-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03007"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 462 AA; 49200 MW; 7E5373F98AD39DC6 CRC64;
MHQPSTAATG TPPATGGARR ALTTGDRAFL HYSRLHPGEY LEAGVVLVLD GPALGVEELR
AHVARRLRAA PALTERLAPP GAPVADLGWE TDPTLDLDHH VTVEDLPPGG GTPALRAAMD
LLAAQPLAAQ PLAAAPLAAQ RPLWRLTLLR GHSPATSAVA YRFSHIHQDG AALHQALHLL
FGADRDPALR SLPAAFPSPR ARDHARMAAA LLRSSTRSRG LAAWGGPPRG EARHSFALAD
LDLLRGLGRR HGATVNDVYL AALAGALRAW SRPEWDRGRR PLHAAMPINL RTRGESEMLS
NITFGTRIRL PCDEDDPRRR LARVAGQTRR VRAAGGLRAV QRRILEAVPP DAPAAMLAHI
ASAGARPTRA ALVASNVGTM RGPYTVAGRP VRTLLGMPPL FVGRQYLSAA LFGLDTQVCA
AFAASASVPG HDALPDLWLA DLAALENAGT PGRRRRIRRT RG
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