ID A0A2I2KPE8_9ACTN Unreviewed; 554 AA.
AC A0A2I2KPE8;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=FRACA_1940011 {ECO:0000313|EMBL:SNQ47547.1};
OS Frankia canadensis.
OC Bacteria; Actinomycetota; Actinomycetes; Frankiales; Frankiaceae; Frankia.
OX NCBI_TaxID=1836972 {ECO:0000313|EMBL:SNQ47547.1, ECO:0000313|Proteomes:UP000234331};
RN [1] {ECO:0000313|EMBL:SNQ47547.1, ECO:0000313|Proteomes:UP000234331}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FRACA_ARgP5 {ECO:0000313|EMBL:SNQ47547.1};
RA Kim H.J., Triplett B.A.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
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DR EMBL; FZMO01000106; SNQ47547.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2I2KPE8; -.
DR OrthoDB; 3713880at2; -.
DR Proteomes; UP000234331; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR PRINTS; PR00851; XRODRMPGMNTB.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000313|EMBL:SNQ47547.1};
KW Helicase {ECO:0000313|EMBL:SNQ47547.1};
KW Hydrolase {ECO:0000313|EMBL:SNQ47547.1};
KW Nucleotide-binding {ECO:0000313|EMBL:SNQ47547.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000234331}.
FT DOMAIN 190..344
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 395..552
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 554 AA; 61623 MW; E0C7ABD7CCFBAD38 CRC64;
MVDGPLIVQS DKTLLLEVDH AGAAEARAAI APFAELERSP EHVHTYRITP LALWNARAAG
HDAEQVVDAL VRHSRYAVPH ALLVDVADTM DRYGRLRLEN DPVHGLVLRA LDRAVLVEVA
RAKRVAPMLG ERLDDDTILV HPSERGRLKQ ALLKLGWPAE DLAGYVDGEK HPIELVQDGW
ELREYQKGAV AGFWEGGSGV VVLPSGAGKT IVGAAAMAQA GATTLILVTN TVAGRQWRHE
LLRRTTLTED EIGEYSGERK EIRPVTIATY QVMTARRKGE YLHLELFGAR DWGLIVYDEV
HLLPAPVFRM TADIQSRRRL GLTATLVRED GREGDVFSLI GPKRYDAPWR EIEAQGWIAP
AECTEVRVTL TDDERMAYAV AEPEERYRMC ATAYSKRAVV RRLVQRHADD RVLVIGAYLD
QLDELGEMLD APVIQGSTRN RERERLFEAF RTGEITTLVV SKVANVSIDL PEAGVAVQVS
GTFGSRQEEA QRLGRVLRPK ADGRTAHFYT VVARDTLDQE YAAHRQRFLA EQGYAYTIVD
ADDIPDPDQT SGQA
//
