ID A0A2I2KTA8_9ACTN Unreviewed; 313 AA.
AC A0A2I2KTA8;
DT 25-APR-2018, integrated into UniProtKB/TrEMBL.
DT 25-APR-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=16S/23S rRNA (Cytidine-2'-O)-methyltransferase TlyA {ECO:0000313|EMBL:SNQ48895.1};
DE EC=2.1.1.226 {ECO:0000313|EMBL:SNQ48895.1};
DE EC=2.1.1.227 {ECO:0000313|EMBL:SNQ48895.1};
GN Name=tlyA {ECO:0000313|EMBL:SNQ48895.1};
GN ORFNames=FRACA_290008 {ECO:0000313|EMBL:SNQ48895.1};
OS Frankia canadensis.
OC Bacteria; Actinomycetota; Actinomycetes; Frankiales; Frankiaceae; Frankia.
OX NCBI_TaxID=1836972 {ECO:0000313|EMBL:SNQ48895.1, ECO:0000313|Proteomes:UP000234331};
RN [1] {ECO:0000313|EMBL:SNQ48895.1, ECO:0000313|Proteomes:UP000234331}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FRACA_ARgP5 {ECO:0000313|EMBL:SNQ48895.1};
RA Kim H.J., Triplett B.A.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TlyA family.
CC {ECO:0000256|ARBA:ARBA00029460}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FZMO01000212; SNQ48895.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2I2KTA8; -.
DR OrthoDB; 9784736at2; -.
DR Proteomes; UP000234331; Unassembled WGS sequence.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR CDD; cd00165; S4; 1.
DR Gene3D; 3.10.290.10; RNA-binding S4 domain; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR004538; Hemolysin_A/TlyA.
DR InterPro; IPR002877; RNA_MeTrfase_FtsJ_dom.
DR InterPro; IPR002942; S4_RNA-bd.
DR InterPro; IPR036986; S4_RNA-bd_sf.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR047048; TlyA.
DR PANTHER; PTHR32319; BACTERIAL HEMOLYSIN-LIKE PROTEIN; 1.
DR PANTHER; PTHR32319:SF0; BACTERIAL HEMOLYSIN-LIKE PROTEIN; 1.
DR Pfam; PF01728; FtsJ; 1.
DR Pfam; PF01479; S4; 1.
DR PIRSF; PIRSF005578; TlyA; 2.
DR SMART; SM00363; S4; 1.
DR SUPFAM; SSF55174; Alpha-L RNA-binding motif; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS50889; S4; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000313|EMBL:SNQ48895.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000234331};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00182};
KW Transferase {ECO:0000313|EMBL:SNQ48895.1}.
FT DOMAIN 6..72
FT /note="RNA-binding S4"
FT /evidence="ECO:0000259|SMART:SM00363"
FT REGION 82..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 288..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 313 AA; 31897 MW; FECC153CA15EF254 CRC64;
MASRRVRLDS ELVRRGLARS REQAVDAISA GRVLVGGIPA TKAATVVDGS TSIALAAGDD
PGWASRGAHK LLGAFAAFGV PPLPGATEPD GDTAEPTAEP EERGQVRLSV AGRRCLDVGA
STGGFTDVLL RHGAASVVAV DVGYGQLLWR LRSDPRVRVL DRVNARALTP EEVGDPAELV
VGDLSFISLA LVLPALRACA APDADFVLLV KPQFEVGRER LGAGGVVRDP ALHAQTVRDV
AASAAVLGLG TRGVTASPLP GPAGNVEYLL WLAAGAPPLD EAALARAIED GPAGSRDGAG
AAAAPGHRAG RSR
//
