ID A0A2I2L256_9ACTN Unreviewed; 399 AA.
AC A0A2I2L256;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Zinc metalloprotease Rip1 {ECO:0000313|EMBL:SNQ51985.1};
DE EC=3.4.24.- {ECO:0000313|EMBL:SNQ51985.1};
GN Name=rip {ECO:0000313|EMBL:SNQ51985.1};
GN ORFNames=FRACA_890013 {ECO:0000313|EMBL:SNQ51985.1};
OS Frankia canadensis.
OC Bacteria; Actinomycetota; Actinomycetes; Frankiales; Frankiaceae; Frankia.
OX NCBI_TaxID=1836972 {ECO:0000313|EMBL:SNQ51985.1, ECO:0000313|Proteomes:UP000234331};
RN [1] {ECO:0000313|EMBL:SNQ51985.1, ECO:0000313|Proteomes:UP000234331}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FRACA_ARgP5 {ECO:0000313|EMBL:SNQ51985.1};
RA Kim H.J., Triplett B.A.;
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the peptidase M50B family.
CC {ECO:0000256|ARBA:ARBA00007931}.
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DR EMBL; FZMO01000557; SNQ51985.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2I2L256; -.
DR Proteomes; UP000234331; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00989; PDZ_metalloprotease; 1.
DR CDD; cd06163; S2P-M50_PDZ_RseP-like; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR004387; Pept_M50_Zn.
DR InterPro; IPR008915; Peptidase_M50.
DR PANTHER; PTHR42837:SF2; MEMBRANE METALLOPROTEASE ARASP2, CHLOROPLASTIC-RELATED; 1.
DR PANTHER; PTHR42837; REGULATOR OF SIGMA-E PROTEASE RSEP; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF02163; Peptidase_M50; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:SNQ51985.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000313|EMBL:SNQ51985.1};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000313|EMBL:SNQ51985.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000234331};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT TRANSMEM 101..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..331
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 371..392
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 120..199
FT /note="PDZ"
FT /evidence="ECO:0000259|SMART:SM00228"
SQ SEQUENCE 399 AA; 42455 MW; 5AAFB4D6973A82E5 CRC64;
MEAGLMEILG IVAFAAALLV SVVAHEGGHF VTARHYGMKA SKFFVGFGPT IWSRQRGETE
YGVKLIPAGG FVKIEGMTPL EEIDPADEPR AFHNARARAR LVVMSAGSVV HFIIAIVLIY
GVLVTLGTTR VSETKIGATS CVATTASCSG PGPAAAAGLR PGDRIVSFDG VAVSTWQDFT
RRVRGHGAGP ATLVVERDGR DLTLRPDLVE VLRDRETGQA GNDRVGALGV KPGLDTERYG
PLEAVPRTFD VIGSGFTGMY DTLTHRIDDL GKIFSKDRDP EGFISVVGAA RIGGDVVSAP
DTSGTDRVRQ FLILVAAINL AVGIFNLLPL LPLDGGHIAV LGFEQARHGL RRLRGYRGPV
KKVDFAKLLP ATYATVVVLL GFSLLLLSAD IVNPIRLNQ
//
