ID A0A2I2U1S7_FELCA Unreviewed; 1139 AA.
AC A0A2I2U1S7;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 2.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Seizure related 6 homolog {ECO:0000313|Ensembl:ENSFCAP00000026400.2};
GN Name=SEZ6 {ECO:0000313|Ensembl:ENSFCAP00000026400.2,
GN ECO:0000313|VGNC:VGNC:65049};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000026400.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000026400.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000026400.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000026400.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000026400.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000026400.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000026400.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
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DR EMBL; AANG04004035; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2U1S7; -.
DR STRING; 9685.ENSFCAP00000026400; -.
DR Ensembl; ENSFCAT00000038470.3; ENSFCAP00000026400.2; ENSFCAG00000007044.6.
DR VGNC; VGNC:65049; SEZ6.
DR GeneTree; ENSGT00940000156995; -.
DR InParanoid; A0A2I2U1S7; -.
DR Proteomes; UP000011712; Chromosome E1.
DR Bgee; ENSFCAG00000007044; Expressed in prefrontal cortex and 4 other cell types or tissues.
DR GO; GO:0097440; C:apical dendrite; IEA:Ensembl.
DR GO; GO:0043198; C:dendritic shaft; IBA:GO_Central.
DR GO; GO:0043197; C:dendritic spine; IBA:GO_Central.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0008344; P:adult locomotory behavior; IEA:Ensembl.
DR GO; GO:0021680; P:cerebellar Purkinje cell layer development; IEA:Ensembl.
DR GO; GO:0060079; P:excitatory postsynaptic potential; IEA:Ensembl.
DR GO; GO:0050773; P:regulation of dendrite development; IBA:GO_Central.
DR GO; GO:0090036; P:regulation of protein kinase C signaling; IBA:GO_Central.
DR GO; GO:0060074; P:synapse maturation; IBA:GO_Central.
DR CDD; cd00033; CCP; 5.
DR CDD; cd00041; CUB; 3.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 5.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR45656; PROTEIN CBR-CLEC-78; 1.
DR PANTHER; PTHR45656:SF1; SEIZURE PROTEIN 6 HOMOLOG; 1.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF00084; Sushi; 5.
DR SMART; SM00032; CCP; 5.
DR SMART; SM00042; CUB; 3.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 5.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 3.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS50923; SUSHI; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Signal {ECO:0000256|SAM:SignalP};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1139
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5016298874"
FT TRANSMEM 916..941
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 348..407
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 409..520
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 523..584
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 586..697
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 701..760
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 762..825
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 829..890
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT REGION 23..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 85..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 152..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..106
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..139
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..168
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 202..217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 409..436
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 731..758
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 1139 AA; 123198 MW; 4ACFA440CA53E2BB CRC64;
MPSVALLLLP SLLALLAHGL SSEAPTTGEG QAPGIEETDG ELTVAPTPEQ PERGVHFVTT
APTLKLLNHH PLLEEFLQEG LEGGEAGLRP ALPFQPDPPT PFTPSPLPRL ANQDSRPVFT
SPTPAMAAAP TQPQSRERPW SLESEAPVLR ITAPLPPVPT PGPGERPSTT PPSRAWTPTQ
EGPGDMGRPW APEVGPQTTG LGMEGTVATS TASGDDEETT ATIITTTITT VQPPGPCSWN
FSGPEGSLDS PMAPSSPIDV GLDCFYYISV YPGYGVEIKV QNISLREGEV VTVEGLGGPD
PLPLANQSFL LRGQVIRSPT HQAALRFQSL PPPAGPGTFH FHYQAYLLNC HFPRRPAYGA
VTVTSLHPGG SARFRCATGY QLKGARILTC LNATQPFWDA QEPVCIAACG GVTRNATTGR
IVSPGFPGNY SNNLTCHWLL EAPEGQRLHL HFEKVSLAED DDRLIIRNGD NVEAPPVYDS
YEVEYLPIEG LLSSGRHFFV ELSTDSSGAA AGMALRYEAF QQGHCYEPFV KYGNFSSSAP
SYPVGTTVEF SCDPGYTLEQ GSIIIECIDP HDPQWNETEP ACRAVCSGEI TDSAGVVLSP
NWPEPYSRGQ DCIWGVHVEE DKRIMLDVRV LRIGPGDVLT FYDGDDLTAR VLGQYSGPRG
HFKLFTSMAD VTIQFQSDPG ASVLGYQQGF VIHFFEVPRN DTCPELPEIP NGWKSPSQPE
LVHGTVVTYQ CYPGYQVVGS SVLMCQWDLT WSEDLPSCQR VTSCHDPGDV EHSRRLISSP
KFPVGATVQY ICDQGFVLTG SAILTCHDRQ ASSPKWSDRA PKCLLEQLKP CHGLSAPENG
AHSPEKRLHP AGATVHFSCA PGYVLKGQAS IKCVPGHPSH WSDPPPICSA ASLDGFYSGR
SLDVAKTPAA SGTLDAAHIA AAIFLPLVVM ALLVGGVYLY FSRLQGKSPL RLPQTRPRPY
DRITVESAFD NPTYEIGVSI YAILCTLSRT SSMLPWAGTP EGPSKPSHSF PFPGEGGLWA
GKPYTSFQLQ AVSLLCRRRK NMKSPSSWGS LEESAQPSIT AQQQSFQPPA VPTPPVHTIW
EETPPIPQEA VPFPTCNALQ GPFSWYHCPH RALPWVQVRG HLPLGRAQLE HTHQEPAFS
//
