ID A0A2I2U2J3_FELCA Unreviewed; 503 AA.
AC A0A2I2U2J3;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Growth/differentiation factor 10 {ECO:0000256|ARBA:ARBA00040122};
DE AltName: Full=Bone morphogenetic protein 3B {ECO:0000256|ARBA:ARBA00042879};
GN Name=GDF10 {ECO:0000313|Ensembl:ENSFCAP00000026667.1,
GN ECO:0000313|VGNC:VGNC:108137};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000026667.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000026667.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000026667.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000026667.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000026667.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000026667.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000026667.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; AANG04000273; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2U2J3; -.
DR STRING; 9685.ENSFCAP00000026667; -.
DR Ensembl; ENSFCAT00000042467.3; ENSFCAP00000026667.1; ENSFCAG00000008962.5.
DR VGNC; VGNC:108137; GDF10.
DR GeneTree; ENSGT00940000157214; -.
DR InParanoid; A0A2I2U2J3; -.
DR Proteomes; UP000011712; Chromosome D2.
DR Bgee; ENSFCAG00000008962; Expressed in tip of external ear and 11 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005125; F:cytokine activity; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0045444; P:fat cell differentiation; IEA:Ensembl.
DR GO; GO:0001649; P:osteoblast differentiation; IEA:InterPro.
DR GO; GO:0045669; P:positive regulation of osteoblast differentiation; IBA:GO_Central.
DR CDD; cd19394; TGF_beta_GDF10; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR017197; BMP3/BMP3B.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF145; GROWTH_DIFFERENTIATION FACTOR 10; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR PIRSF; PIRSF037403; BMP3/GDF10; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR037403-1};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..503
FT /note="Growth/differentiation factor 10"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014125613"
FT DOMAIN 365..477
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 266..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..326
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 375..442
FT /evidence="ECO:0000256|PIRSR:PIRSR037403-1"
FT DISULFID 404..474
FT /evidence="ECO:0000256|PIRSR:PIRSR037403-1"
FT DISULFID 408..476
FT /evidence="ECO:0000256|PIRSR:PIRSR037403-1"
FT DISULFID 441
FT /note="Interchain"
FT /evidence="ECO:0000256|PIRSR:PIRSR037403-1"
SQ SEQUENCE 503 AA; 55227 MW; DECA2EC5255D91A5 CRC64;
MARGPAGTSP GRRPQLLPLL PLLLLLLRDA GGSHPAPAWS ASPAASDGLA GIKDPWRSLG
DAATTLGPGA QDMVAVHMLR LYEKYSRRGA RPGGGNTVRS FRARLEVVDQ KAVYFFNLTS
MQDSEMILAA TFHFYAEPRW PRAREAPCKQ RAKNVSCRLL PLGLPARQHL LFRSLSQNTA
TQGLLRGAMA LAPPPRGLWQ AKDISPIVKA ARQDGELILS AQLDPGEKAP GGSRPSPHAP
YILVYADDLA ISEPNSVAVT LQRYDPFQAG DPEPGAAPNS SADPRVRRAT QATGPLQDNE
LPGLDERPAH ASHAQHYHKH ELWPGPFRAL KPRPGRKDRR KKGPDVFVGS SRVLDFDEKT
MQKARRKQWA EPRVCSRRYL KVDFADIGWN EWIILPKSFD AYYCAGVCEF PMPKMVRPSN
HATIQSIVRA VGIVPGIPEP CCVPDKMNSL GVLFLDENRN VVLKVYPNMS VETCACRCCL
SCGHGRVSLP EAHLALQHLH SQA
//
