ID A0A2I2U3T0_FELCA Unreviewed; 1010 AA.
AC A0A2I2U3T0;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 2.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=PPFIA binding protein 1 {ECO:0000313|Ensembl:ENSFCAP00000027080.2};
GN Name=PPFIBP1 {ECO:0000313|Ensembl:ENSFCAP00000027080.2,
GN ECO:0000313|VGNC:VGNC:68985};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000027080.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000027080.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000027080.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000027080.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000027080.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000027080.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000027080.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the liprin family. Liprin-beta subfamily.
CC {ECO:0000256|ARBA:ARBA00007547}.
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DR EMBL; AANG04001751; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_011282163.1; XM_011283861.2.
DR AlphaFoldDB; A0A2I2U3T0; -.
DR STRING; 9685.ENSFCAP00000027080; -.
DR Ensembl; ENSFCAT00000040954.3; ENSFCAP00000027080.2; ENSFCAG00000007533.6.
DR GeneID; 101082578; -.
DR CTD; 8496; -.
DR VGNC; VGNC:68985; PPFIBP1.
DR GeneTree; ENSGT01050000244951; -.
DR InParanoid; A0A2I2U3T0; -.
DR OMA; VETQPCD; -.
DR Proteomes; UP000011712; Chromosome B4.
DR Bgee; ENSFCAG00000007533; Expressed in zone of skin and 10 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0048786; C:presynaptic active zone; IBA:GO_Central.
DR GO; GO:0007528; P:neuromuscular junction development; IBA:GO_Central.
DR CDD; cd09563; SAM_liprin-beta1_2_repeat1; 1.
DR CDD; cd09566; SAM_liprin-beta1_2_repeat2; 1.
DR CDD; cd09569; SAM_liprin-beta1_2_repeat3; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 3.
DR InterPro; IPR029515; Liprin.
DR InterPro; IPR037617; Liprin-beta_SAM_rpt_1.
DR InterPro; IPR037618; Liprin-beta_SAM_rpt_2.
DR InterPro; IPR037619; Liprin-beta_SAM_rpt_3.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR12587; LAR INTERACTING PROTEIN LIP -RELATED PROTEIN; 1.
DR PANTHER; PTHR12587:SF16; LIPRIN-BETA-1; 1.
DR Pfam; PF00536; SAM_1; 2.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00454; SAM; 3.
DR SUPFAM; SSF144266; MPN010-like; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 3.
DR PROSITE; PS50105; SAM_DOMAIN; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 646..710
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 718..781
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 449..585
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 599..633
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 99..227
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 252..339
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 449..471
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 472..490
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1010 AA; 113703 MW; 853A816FB0A090AE CRC64;
MMSDASDMLA AALEQMDGII AGSKALEYSN GIFDCQSPTS PFMGSLRALH LVEDLRGLLE
MMDTDEKEGL RCQIPDSTAE TLVEWLQSQV TNGHLPGNGE VYQERLARLE NDKESLVLQV
SVLTDQVEAQ GEKIRDLEFC LEEHREKLNA TEEMLQQELL SRTSLETQKL DLMAEISNLK
LKLTAVEKDR LDYEDRFRDT EGLMQEINDL RLRVSEMDNE RLQYEKKLKS TKSLMAKLSS
MKIKVGQMQY EKQRMERKWE SLKDELASLK EQLEEKESEV KRLQEKLVCK MKGEGMEILD
RDIEVQKMKK AVESLMAANE EKDRKIEDLR QCLNRYKKMQ DTVVLAQGQD SNFEDLLTSS
SISTLLDAQG FSDLEKSLSP TPVMGSPSRD PFNTSVPEEF HTGILQVSVP SLLPTSKGLE
ISEKAKLPQP ETSFEENDGK IILGAAVETQ PSDSLSTSSL QKSSSLGNLK KESSDGDTES
VQKPSEDKTP TERSPFGSLP PKAPGHDASM DDNPFGTRKA RSSFGRGFFK IKSNKRTASA
PNLAETEKET AEHLDLAGVS SRPKDAPGSS PFQISPPSPD SKKKSRGIMK LFGKLRRSQS
TTFNPDDMSE PEFKRGGTRA TAGPRLGWSR DLGQSNSDLD MPFAKWTKEQ VCNWLVEQGL
GSYLNSGKHW IASGQTLLQA SQQDLEKELG IKHSLHRKKL QLALQALGSE EETNHGKLDF
NWVTRWLDDI GLPQYKTQFD EGRVDGRMLH YMTVDDLLSL KVVSVLHHLS IKRAIQVLRI
NNFEPNCLRR RPSDENSITP SEVQQWTNHR VMEWLRSVDL AEYAPNLRGS GVHGGLMVLE
PRFNVETMAQ LLNIPPSKTL LRRHLATHFN LLIGAEAQHQ KRDAMELPDY VLLTATAKVK
PKKLTFSNFG NLRKKKQEDG EEYVCPMELG QASGSTCKKG FKPGLDMRLY DEDELDRLEQ
MEDSEGTVRQ IGAFSEGINN LTHMLKEDDM FRDFAARSPS ASITDEDSNV
//
