ID A0A2I2U410_FELCA Unreviewed; 926 AA.
AC A0A2I2U410;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Protein tyrosine phosphatase receptor type N2 {ECO:0000313|Ensembl:ENSFCAP00000027178.3};
GN Name=PTPRN2 {ECO:0000313|Ensembl:ENSFCAP00000027178.3,
GN ECO:0000313|VGNC:VGNC:80666};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000027178.3, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000027178.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000027178.3,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000027178.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000027178.3,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000027178.3}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000027178.3};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004212}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004212}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; AANG04001389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2U410; -.
DR Ensembl; ENSFCAT00000038142.3; ENSFCAP00000027178.3; ENSFCAG00000007989.6.
DR VGNC; VGNC:80666; PTPRN2.
DR GeneTree; ENSGT00940000154095; -.
DR Proteomes; UP000011712; Chromosome A2.
DR Bgee; ENSFCAG00000007989; Expressed in prefrontal cortex and 8 other cell types or tissues.
DR GO; GO:0030141; C:secretory granule; IEA:InterPro.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR Gene3D; 3.30.70.2470; Protein-tyrosine phosphatase receptor IA-2 ectodomain; 1.
DR InterPro; IPR033522; IA-2/IA-2_beta.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR021613; Receptor_IA-2_dom.
DR InterPro; IPR038112; Receptor_IA-2_ectodomain_sf.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46106; IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C; 1.
DR PANTHER; PTHR46106:SF5; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE N2; 1.
DR Pfam; PF11548; Receptor_IA-2; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SMART; SM01305; RESP18; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Signal {ECO:0000256|SAM:SignalP}; Synapse {ECO:0000256|ARBA:ARBA00023018};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..926
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023940503"
FT TRANSMEM 591..615
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 656..916
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 835..907
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 107..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 194..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 242..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 322..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..121
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 122..136
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 333..364
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 926 AA; 100858 MW; 46B6840E11021BB4 CRC64;
MGPLLALLLL LLLPPPRTAP APRTRQLPGL LGCLFEDGLC RPSETCVNDG VFGRCQKVPA
VDTHRYEVSP AVLQHLAATL QKLSRTGFTW QDDYTQHVMA QELLNLPSPQ HLDASSTART
SKQSVDEDRR SSLEDDGGLA RAVQRYLPYL EALSQAVAPN VRLRTKHNRQ SAQGEDPLAD
SVLTFMAQTS ALTYAPGPGA DYPGGRPLRT PGRLQPDELS PKVDGNVNRQ KLIAALGAYA
ARKPPAPHGE GDPWPRNPLH APWKTPRVLS APVEPRKWPS PPGDPKLPEA MSGETPIQSL
LKGLGEQPDL GEAARAIASA MQAVGAEGEP RGAEKGAAGK PRESDAGRRG GGVPDDRVPD
GGGRAYEEVS RLSLELGDRL PDPGSQLSPA VPPLSEPFKM EAKKSEAAEA PPTWEEESAG
VEDVRSQTYS KERLQRPPPA EPGTGGFGEF RPWVPRPSQE DAHLTAGAQG RPTEELRLEV
KPSQEDHGYI VTGTDPLSPE KGKELMEGVA QLLEVPMSVF ADIVVVGPAV TFRLSASVQN
LTTGDVAQAT VDNKDKLEKA SGLEILRAGS GSKSKLKLPP RRAKQGDSTP FIVLTLVSVV
AMVGVLLASG VIYCLRHTSR ARLQDKLSGP GDHPGPDATA AYQAYMEDHL KNKNRLEKEW
EALCAYQAEP NSSLVAQRAE NAHKNRSPAV LTYDHSRVLL RSENSHSRSD YINASPIMDH
DPRNPAYIAT QGPLPATVAD FWQMVWESGC VVIVMLTSLS ENGICQCCHY WPDEGSSLYH
VYEVNLVSEH IWCEDFLVRS FYLKNLQTNE TRTVTQFHFL SWCDRGVPSS ARSLLDFRRK
VNKCYRGRSC PIIVHCSDGA GRSGTYVLID MVLNKMAKGA KEIDIAATLE HLRDQRPGMV
QTKGQFEFAL TAVAEEVNAI LRALPQ
//