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Database: UniProt
Entry: A0A2I2U410_FELCA
LinkDB: A0A2I2U410_FELCA
Original site: A0A2I2U410_FELCA 
ID   A0A2I2U410_FELCA        Unreviewed;       926 AA.
AC   A0A2I2U410;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2019, sequence version 3.
DT   24-JAN-2024, entry version 29.
DE   SubName: Full=Protein tyrosine phosphatase receptor type N2 {ECO:0000313|Ensembl:ENSFCAP00000027178.3};
GN   Name=PTPRN2 {ECO:0000313|Ensembl:ENSFCAP00000027178.3,
GN   ECO:0000313|VGNC:VGNC:80666};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000027178.3, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000027178.3, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000027178.3,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA   Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA   Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA   Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000027178.3, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000027178.3,
RC   ECO:0000313|Proteomes:UP000011712};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000027178.3}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000027178.3};
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle membrane
CC       {ECO:0000256|ARBA:ARBA00004212}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004212}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC       {ECO:0000256|ARBA:ARBA00004479}.
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DR   EMBL; AANG04001389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A2I2U410; -.
DR   Ensembl; ENSFCAT00000038142.3; ENSFCAP00000027178.3; ENSFCAG00000007989.6.
DR   VGNC; VGNC:80666; PTPRN2.
DR   GeneTree; ENSGT00940000154095; -.
DR   Proteomes; UP000011712; Chromosome A2.
DR   Bgee; ENSFCAG00000007989; Expressed in prefrontal cortex and 8 other cell types or tissues.
DR   GO; GO:0030141; C:secretory granule; IEA:InterPro.
DR   GO; GO:0045202; C:synapse; IEA:UniProtKB-KW.
DR   GO; GO:0030658; C:transport vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR   GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR   Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR   Gene3D; 3.30.70.2470; Protein-tyrosine phosphatase receptor IA-2 ectodomain; 1.
DR   InterPro; IPR033522; IA-2/IA-2_beta.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000242; PTP_cat.
DR   InterPro; IPR021613; Receptor_IA-2_dom.
DR   InterPro; IPR038112; Receptor_IA-2_ectodomain_sf.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   InterPro; IPR000387; Tyr_Pase_dom.
DR   PANTHER; PTHR46106; IA-2 PROTEIN TYROSINE PHOSPHATASE, ISOFORM C; 1.
DR   PANTHER; PTHR46106:SF5; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE N2; 1.
DR   Pfam; PF11548; Receptor_IA-2; 1.
DR   Pfam; PF00102; Y_phosphatase; 1.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM00194; PTPc; 1.
DR   SMART; SM00404; PTPc_motif; 1.
DR   SMART; SM01305; RESP18; 1.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE   4: Predicted;
KW   Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Signal {ECO:0000256|SAM:SignalP}; Synapse {ECO:0000256|ARBA:ARBA00023018};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           21..926
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5023940503"
FT   TRANSMEM        591..615
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          656..916
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS50055"
FT   DOMAIN          835..907
FT                   /note="Tyrosine specific protein phosphatases"
FT                   /evidence="ECO:0000259|PROSITE:PS50056"
FT   REGION          107..137
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          194..224
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          242..292
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          322..475
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        107..121
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        122..136
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        333..364
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   926 AA;  100858 MW;  46B6840E11021BB4 CRC64;
     MGPLLALLLL LLLPPPRTAP APRTRQLPGL LGCLFEDGLC RPSETCVNDG VFGRCQKVPA
     VDTHRYEVSP AVLQHLAATL QKLSRTGFTW QDDYTQHVMA QELLNLPSPQ HLDASSTART
     SKQSVDEDRR SSLEDDGGLA RAVQRYLPYL EALSQAVAPN VRLRTKHNRQ SAQGEDPLAD
     SVLTFMAQTS ALTYAPGPGA DYPGGRPLRT PGRLQPDELS PKVDGNVNRQ KLIAALGAYA
     ARKPPAPHGE GDPWPRNPLH APWKTPRVLS APVEPRKWPS PPGDPKLPEA MSGETPIQSL
     LKGLGEQPDL GEAARAIASA MQAVGAEGEP RGAEKGAAGK PRESDAGRRG GGVPDDRVPD
     GGGRAYEEVS RLSLELGDRL PDPGSQLSPA VPPLSEPFKM EAKKSEAAEA PPTWEEESAG
     VEDVRSQTYS KERLQRPPPA EPGTGGFGEF RPWVPRPSQE DAHLTAGAQG RPTEELRLEV
     KPSQEDHGYI VTGTDPLSPE KGKELMEGVA QLLEVPMSVF ADIVVVGPAV TFRLSASVQN
     LTTGDVAQAT VDNKDKLEKA SGLEILRAGS GSKSKLKLPP RRAKQGDSTP FIVLTLVSVV
     AMVGVLLASG VIYCLRHTSR ARLQDKLSGP GDHPGPDATA AYQAYMEDHL KNKNRLEKEW
     EALCAYQAEP NSSLVAQRAE NAHKNRSPAV LTYDHSRVLL RSENSHSRSD YINASPIMDH
     DPRNPAYIAT QGPLPATVAD FWQMVWESGC VVIVMLTSLS ENGICQCCHY WPDEGSSLYH
     VYEVNLVSEH IWCEDFLVRS FYLKNLQTNE TRTVTQFHFL SWCDRGVPSS ARSLLDFRRK
     VNKCYRGRSC PIIVHCSDGA GRSGTYVLID MVLNKMAKGA KEIDIAATLE HLRDQRPGMV
     QTKGQFEFAL TAVAEEVNAI LRALPQ
//
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