ID A0A2I2U640_FELCA Unreviewed; 1896 AA.
AC A0A2I2U640;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 2.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Ankyrin 1 {ECO:0000313|Ensembl:ENSFCAP00000027899.2};
GN Name=ANK1 {ECO:0000313|Ensembl:ENSFCAP00000027899.2,
GN ECO:0000313|VGNC:VGNC:67578};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000027899.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000027899.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000027899.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000027899.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000027899.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000027899.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000027899.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; AANG04001605; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9685.ENSFCAP00000027899; -.
DR Ensembl; ENSFCAT00000037334.3; ENSFCAP00000027899.2; ENSFCAG00000012951.6.
DR VGNC; VGNC:67578; ANK1.
DR GeneTree; ENSGT00940000155760; -.
DR InParanoid; A0A2I2U640; -.
DR OMA; TKYEDNQ; -.
DR Proteomes; UP000011712; Chromosome B1.
DR Bgee; ENSFCAG00000012951; Expressed in prefrontal cortex and 8 other cell types or tissues.
DR GO; GO:0170014; C:ankyrin-1 complex; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0009898; C:cytoplasmic side of plasma membrane; IEA:Ensembl.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0014731; C:spectrin-associated cytoskeleton; IEA:Ensembl.
DR GO; GO:0051117; F:ATPase binding; IEA:Ensembl.
DR GO; GO:0008093; F:cytoskeletal anchor activity; IBA:GO_Central.
DR GO; GO:0019903; F:protein phosphatase binding; IEA:Ensembl.
DR GO; GO:0030507; F:spectrin binding; IBA:GO_Central.
DR GO; GO:0044325; F:transmembrane transporter binding; IBA:GO_Central.
DR GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IEA:Ensembl.
DR GO; GO:0072659; P:protein localization to plasma membrane; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08805; Death_ank1; 1.
DR Gene3D; 2.60.220.30; -; 2.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24198; ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24198:SF173; ANKYRIN-3; 1.
DR Pfam; PF00023; Ank; 3.
DR Pfam; PF12796; Ank_2; 7.
DR Pfam; PF13637; Ank_4; 2.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 23.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 20.
DR PROSITE; PS50088; ANK_REPEAT; 20.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 110..142
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 143..175
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 176..200
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 238..270
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 271..303
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 304..336
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 337..369
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 370..402
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 403..435
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 436..468
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 469..501
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 502..534
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 535..567
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 568..600
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 601..625
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 634..666
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 667..699
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 700..732
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 733..765
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 766..798
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 953..1108
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1110..1256
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 1443..1527
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 913..944
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1525..1555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1677..1716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1803..1840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1875..1896
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..33
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1530..1545
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1680..1695
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1697..1716
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1803..1825
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1826..1840
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1896 AA; 208711 MW; 2A1B2EB8EFFAEBD6 CRC64;
MAQAAKQLKK IKDIEAQALQ EQKEKEESNR KRRNRSRDRK KKADAATSFL RAARSGNLDK
ALDHLRNGVD INTCNQNGLN GLHLASKEGH VKMVVELLHK EIILETTTKK GNTALHIAAL
AGQDEVVREL VNYGANVNAQ SQKGFTPLYM AAQENHLEVV KFLLENGANQ NVATEDGFTP
LAVALQQGHE NVVAHLINYG TKGKVRLPAL HIAARNDDTR TAAVLLQNDP NPDVLSKTGF
TPLHIAAHYE NLNVAQLLLN RGASVNFTPQ NGITPLHIAS RRGNVIMVRL LLDRGAQIET
RTKDELTPLH CAARNGHVRI SEILLDHGAP IQAKTKNGLS PIHMAAQGDH LDCVRLLLQY
NAEIDDITLD HLTPLHVAAH CGHHRVAKVL LDKGAKPNSR ALNGFTPLHI ACKKNHIRVM
ELLLKTGASI DAVTESGLTP LHVASFMGHL PIVKNLLQRG ASPNVSNVKV ETPLHMAARA
GHTEVAKYLL QNKAKVNAKA KDDQTPLHCA ARIGHTNMVK LLLENNANPN LATTAGHTPL
HIAAREGHVE TVLALLEKEA SQACMTKKGF TPLHVAAKYG KVRVAEVLLE RDAHPNAAGK
NGLTPLHVAV HHNHLDIVRL LLPRGGSPHS PAWNGYTPLH IAAKQNQIEV ARSLLQYGGS
ANAESVQGVT PLHLAAQEGH AEMVALLLSK QANGNLGNKS GLTPLHLVAQ EGHVPVADVL
IKHGVMVDAT TRMGYTPLHV ASHYGNIKLV KFLLQHQADV NAKTKQGYSP LHQAAQQGHT
DIVTLLLKNG ASPNEVSSNG TTPLAIAKRL GYISVTDVLK VVTDETSFVL ASDKHRLSFP
ETVDEILDVS EDEGTAHITI MGEELVSKAE KQDSRDIDEE KELLDFVPKL DQVVESPAIP
RIPCVTPETV VIRSEEPEQA SKEYDEDSLI PSSPATETSD NISPVASPVH TGFLVSFMVD
ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS TPPPLAEEEG LASRIIALGP
AGAQFLSPVI VEIPHFASQG RGDRELVVLR SENGSVWKEH KSRYGESYLD QILNGMDEEL
GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG GFLKSKLVPL VQATFPENAV
TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK FYRPIGLRIP LPPSWTDNPR
DSGEGDTTSL RLLCSVTGGT DQAQWEDITG TTKLVYANEC AAFTTNVSAR FWLSDCPRTA
EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC MTDDKVDKTL EQHENFIEVA
RSRDIEVLEG MPLFAELFGN LVPVKKAAQQ RSFLFQSFRE NRLAIPVKVR DSSREPAGSL
SFLRKAMKYE DTQHILCHLN ITMPPCTKGS GADDRKRTLT PLALRYSILS ESSLGFLSGT
DRADMKMAII SEHLGLSWAE LARELQFSVE DINRIRVENP NSLLEQSAAL LNLWVTREGK
NAKMDNLYAA LRSIDRSEIV NMLEGSGRQS RNLKPDRRHR DRDYSSSPSQ MNGYSSLQDE
LLSPASLQYA LPSPLRADQY WNEVAVIDAI PLAATEHDTM LEMSDMQVWS AGLTPSLVTA
EDSSLECSKA EDSDATGHEW KLEGVLSEGP QGPMLGSLDL VEDDTVDSDA TNGLIDLLDQ
EEGQRSEEKL PGHKSQEDST GVGQDSENEV SLVSGQQRVQ AHITESPSVS RVMETSQDRL
QDWEEEGSIV SYLQDAAQSS WQEEVVHGPH SFQSTVTTIK ELEPSGSQEY EKVLMSATEH
IWEEQPEAES LQADRERRRQ SHQEWVQEAR STFSQMAEGN EFQSIPGEQV TEEQFTDEQG
NIVTKKIIRK VVRQIDSSGA DDTQEHEEDH TSTPNP
//
