ID A0A2I2U642_FELCA Unreviewed; 421 AA.
AC A0A2I2U642;
DT 10-OCT-2018, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Keratin, type I cytoskeletal 20 {ECO:0000256|ARBA:ARBA00040318};
DE AltName: Full=Cytokeratin-20 {ECO:0000256|ARBA:ARBA00041717};
DE AltName: Full=Keratin-20 {ECO:0000256|ARBA:ARBA00042487};
GN Name=KRT20 {ECO:0000313|Ensembl:ENSFCAP00000027925.2,
GN ECO:0000313|VGNC:VGNC:99096};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000027925.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000027925.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000027925.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000027925.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000027925.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000027925.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000027925.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Plays a significant role in maintaining keratin filament
CC organization in intestinal epithelia. When phosphorylated, plays a role
CC in the secretion of mucin in the small intestine.
CC {ECO:0000256|ARBA:ARBA00037685}.
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC Associates with KRT8. {ECO:0000256|ARBA:ARBA00038712}.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
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DR EMBL; AANG04003358; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2U642; -.
DR STRING; 9685.ENSFCAP00000027925; -.
DR PaxDb; 9685-ENSFCAP00000001869; -.
DR Ensembl; ENSFCAT00000042095.3; ENSFCAP00000027925.2; ENSFCAG00000043236.2.
DR VGNC; VGNC:99096; KRT20.
DR GeneTree; ENSGT00940000161855; -.
DR InParanoid; A0A2I2U642; -.
DR OMA; LGTIMNE; -.
DR Proteomes; UP000011712; Chromosome E1.
DR Bgee; ENSFCAG00000043236; Expressed in zone of skin.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0009267; P:cellular response to starvation; IEA:Ensembl.
DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR GO; GO:0050708; P:regulation of protein secretion; IEA:Ensembl.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR PANTHER; PTHR23239:SF167; KERATIN, TYPE I CYTOSKELETAL 20; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685}; Keratin {ECO:0000256|ARBA:ARBA00022744};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 76..374
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT COILED 80..107
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 150..219
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 244..313
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 421 AA; 48073 MW; 83B813D4332E93D4 CRC64;
MEFTGRSFHR SLSSSLQGPA LSMRGSMYGK GGMQHFGAAP SVYGGAGGQG IRISTSRPMV
GYGSDLTRGD VFAGNDKMTM QNLNDRLASY LEKVHSLEQS NSKLELLIKQ WYETNTPGIR
DDSAYYQQIK ELQNQIKSVQ LQNFHCVLQI DNAKLAAEDL RLKYEAERET RLTVESDIQG
LNKVSADLSL SRTDLEIQIK ELTKDLDLLK KEHQEEVDSL RRHLGDTVCV EVDAAPGLEL
GTVMNELRQK YETIVQENLQ KAKEQFETQV IIKDNEAQVK ELRHTYRNLE IELQSHLSMK
ESLERTLEET RARYGSQLAT IQALLNSIEA QMTQIWSDTE RQNKEYNILL DIKTRLEQEI
ATYRRLLEGE DVIQTNTTIE HLPSTLEEKD VKRKRKIKTI VEEVVDGKVV SCETKEMEED
V
//
