ID A0A2I2UA81_FELCA Unreviewed; 1194 AA.
AC A0A2I2UA81;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Erythrocyte membrane protein band 4.1 like 3 {ECO:0000313|Ensembl:ENSFCAP00000029359.3};
GN Name=EPB41L3 {ECO:0000313|Ensembl:ENSFCAP00000029359.3,
GN ECO:0000313|VGNC:VGNC:61894};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000029359.3, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000029359.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000029359.3,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000029359.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000029359.3,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000029359.3}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000029359.3};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04003548; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2UA81; -.
DR Ensembl; ENSFCAT00000042747.3; ENSFCAP00000029359.3; ENSFCAG00000011079.6.
DR VGNC; VGNC:61894; EPB41L3.
DR GeneTree; ENSGT00940000157047; -.
DR Proteomes; UP000011712; Chromosome D3.
DR Bgee; ENSFCAG00000011079; Expressed in prefrontal cortex and 9 other cell types or tissues.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0030866; P:cortical actin cytoskeleton organization; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd13184; FERM_C_4_1_family; 1.
DR CDD; cd17203; FERM_F1_EPB41L3; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR030691; Band4.1-L3_FERM_F1.
DR InterPro; IPR008379; Band_4.1_C.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR000798; Ez/rad/moesin-like.
DR InterPro; IPR014847; FA.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR019747; FERM_CS.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR018979; FERM_N.
DR InterPro; IPR018980; FERM_PH-like_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR007477; SAB_dom.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR23280; 4.1 G PROTEIN; 1.
DR PANTHER; PTHR23280:SF20; BAND 4.1-LIKE PROTEIN 3; 1.
DR Pfam; PF05902; 4_1_CTD; 1.
DR Pfam; PF08736; FA; 1.
DR Pfam; PF09380; FERM_C; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF09379; FERM_N; 1.
DR Pfam; PF04382; SAB; 1.
DR PIRSF; PIRSF002304; Membrane_skeletal_4_1; 2.
DR PRINTS; PR00935; BAND41.
DR PRINTS; PR00661; ERMFAMILY.
DR SMART; SM00295; B41; 1.
DR SMART; SM01195; FA; 1.
DR SMART; SM01196; FERM_C; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS00660; FERM_1; 1.
DR PROSITE; PS00661; FERM_2; 1.
DR PROSITE; PS50057; FERM_3; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 111..392
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 1..70
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 82..101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 480..547
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 773..847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 914..951
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 991..1072
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 37..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 489..532
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..816
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1003..1018
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1026..1046
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1194 AA; 132100 MW; 279528965CFD4625 CRC64;
MTTESGSDSE SKPEQEAEPQ EAAGAQGQAG AQQRGPEPSG EDQQQALEQF EGAAHSTPVR
KEVTDKEREF AAGAAKQLEY QQLEDDKLSQ KSSSSKLSRS PLKIVKKPKS MQCKVILLDG
SEYICDVEKR SRGQVLFDKV CEHLNLLEKD YFGLTYRDAE NQKNWLDPAK EIKKQIRSGA
WHFSFNVKFY PPDPAQLSED ITRYYLCLQL RDDIVSGRLP CSFVTLALLG SYTVQSELGD
YDPDECGNDY ISEFRFAPNH TKELEDKVIE LHKSHRGMTP AEAEMHFLEN AKKLSMYGVD
LHHAKDSEGV EIMLGVCASG LLIYRDRLRI NRFAWPKVLK ISYKRNNFYI KIRPGEFEQF
ESTIGFKLPN HRAAKRLWKV CVEHHTFFRL LLPEAPPKKF LTLGSKFRYS GRTQAQTRRA
SALIDRPAPY FERSSSKRYT MSRSLDGASV NENHEIYMKD SVSAAEVGTG QYATTKGISQ
TNLITTVTPE KKAEEERDEE EERRKKAEEA TPVAAVRHEG KTDSERTDTA ADGETTATES
DQEEDAELKA QELDKTQDDL MKHQTNISEL KRTFLETSTD TAITNEWEKR LSTSPVRLAA
RQEDAPMIEP LVPEETEEER EISEKVIFLQ QESSPFLESQ GTEDWVIVDK VPTEVVDGDS
KKIVTYKVVT VSSRTGDIPA DLLRSGAIEM QSFEDLALEM QLKGESKQKI YTLGKSYDTV
SGKIVTMTGK AKEGEKAVQP CGLEALQKAD RALSESVKII PVTADYEVLD VAPDEKSRRG
PEVHTPKRKL SESLAPIKEA DSRRPSPEED ELQRAPGPGR DAAPHAGPEG ARPGRTEPAP
EGEVLKVGLF GPRRKSLSEW RYSQEPAFTV ATAHYVTESS SSRVVTKQSS AEKLMDGSEI
FSLLDSARKP TEFIGGVTST SQSWVQKTET KTGPSKTEPE TSQHPQSLSA EKVVQETVLV
EERHVMNVHA SGDASYAAGE DVDAAAQAAS ADASGLKGKE GSALTEGAKE EKGEVAGKAV
LEQEGTATAS HESEEQQSAA THVSETWEQK PHFESSTVKT ETISFGSVSP GGVKLEISTK
EVPVVHTETK TITYESSQVD PGADLEPGVL MSAQTITSET TSTTTTTHIT KTVKGGISET
RIEKRIVITG DADIDHDQAL AQAIKEAKEQ HPDMSVTKVV VHKETEITPE DGED
//
