ID A0A2I2UDB1_FELCA Unreviewed; 2533 AA.
AC A0A2I2UDB1;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Teneurin transmembrane protein 2 {ECO:0000313|Ensembl:ENSFCAP00000030440.3};
GN Name=TENM2 {ECO:0000313|Ensembl:ENSFCAP00000030440.3,
GN ECO:0000313|VGNC:VGNC:66070};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000030440.3, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000030440.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000030440.3,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000030440.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000030440.3,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000030440.3}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000030440.3};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004162};
CC Single-pass membrane protein {ECO:0000256|ARBA:ARBA00004162}. Membrane
CC {ECO:0000256|ARBA:ARBA00004167}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the tenascin family. Teneurin subfamily.
CC {ECO:0000256|ARBA:ARBA00009385}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AANG04001174; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSFCAT00000047206.3; ENSFCAP00000030440.3; ENSFCAG00000007084.6.
DR VGNC; VGNC:66070; TENM2.
DR GeneTree; ENSGT01030000234566; -.
DR Proteomes; UP000011712; Chromosome A1.
DR Bgee; ENSFCAG00000007084; Expressed in zone of skin and 9 other cell types or tissues.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 3.
DR Gene3D; 2.10.25.10; Laminin; 6.
DR Gene3D; 2.180.10.10; RHS repeat-associated core; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR011044; Quino_amine_DH_bsu.
DR InterPro; IPR022385; Rhs_assc_core.
DR InterPro; IPR009471; Ten_N.
DR InterPro; IPR028916; Tox-GHH_dom.
DR InterPro; IPR006530; YD.
DR NCBIfam; TIGR03696; Rhs_assc_core; 1.
DR NCBIfam; TIGR01643; YD_repeat_2x; 1.
DR PANTHER; PTHR11219; TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR PANTHER; PTHR11219:SF8; TENEURIN-2; 1.
DR Pfam; PF06484; Ten_N; 1.
DR Pfam; PF15636; Tox-GHH; 1.
DR SMART; SM00181; EGF; 8.
DR SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR SUPFAM; SSF50969; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR PROSITE; PS00022; EGF_1; 4.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 3.
DR PROSITE; PS51361; TENEURIN_N; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 143..168
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..143
FT /note="Teneurin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51361"
FT DOMAIN 436..468
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 470..503
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 565..600
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 458..467
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 493..502
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 569..579
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 590..599
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2533 AA; 281102 MW; B758DBD332C91F48 CRC64;
MKLQNGPPNH HSQSTLRPPL PPPHNHTLSH HHSSANSLNR NSLTNRRSQI HAPAPAPNDL
ATTPESVQLQ DSWVLNSNVP LETRHFLFKT SSGSTPLFSS SSPGYPLTSG TVYTPPPRLL
PRNTFSRKAF KLKKPSKYCS WKCAALSAIA AALLLAILLA YFIAMHLLGL NWQLQPADGH
TFNNGIRTGL PGSDDVATMP SGGKVPWSLK NSSIDSGEAE VGRRVTQEVP PGVFWRSQIH
ISQPQFLKFN ISLGKDALFG VYIRRGLPPS HAQYDFMERL DGKEKWSVVE SPRERRSIQT
LVQNEAVFVQ YLDVGLWHLA FYNDGKDKEM VSFNTVVLDS VQDCPRNCHG NGECVSGLCH
CFPGFLGADC AKAACPVLCS GNGQYSKGTC QCYSGWKGAE CDVPMNQCID PSCGGHGSCI
DGNCVCSAGH KGEHCEEVDC LDPTCSSHGV CVNGECLCSP GWGGLNCELA RVQCPDQCSG
HGTYVPDTGL CSCDPNWMGP DCSVEVCSVD CGTHGVCIGG ACRCEEGWTG AACDQRVCHP
RCIEHGTCKD GKCECREGWN GEHCTIDGCP DLCNGNGRCT LGQNSWQCVC QTGWRGPGCN
VAMETSCADN KDNEGDGLVD CLDPDCCLQS ACQNSLLCRG SRDPLDIIQQ GQTDSPAVKS
FYDRIKLLAG KDSTHIIPGD NPFNSSLVSL IRGQVVTTDG TPLVGVNVSF VKYPKYGYTI
TRQDGTFDLI ANGGASLTLH FERAPFMSQE RTVWLPWNSF YAMDTLVMKT EENSIPSCDL
SGFVRPDPII ISSPLSTFFS AAPGQNPIVP ETQVLHEEIE LPGSTVKLRY LSSRTAGYKS
LLKITMTQST VPLNLIKVHL MVAVEGHLFQ KSFQASPNLA YTFIWDKTDA YGQRVYGLSD
AVVSVGFEYE TCPSLILWEK RTALLQGFEL DPSNLGGWSL DKHHILNVKS GILHKGTGEN
QFLTQQPAII TSIMGNGRRR SISCPSCNGL AEGNKLLAPV ALAVGIDGSL FVGDFNYIRR
IFPSRNVTSI LELRNKEFKH SNNPAHKYYL AVDPVSGSLY VSDTNSRRIY RVKSLSGAKD
LAGNSEVVAG TGEQCLPFDE ARCGDGGKAV DATLMSPRGI AVDKNGLMYF VDATMIRKVD
QNGIISTLLG SNDLTAVRPL SCDSSMDVAQ VRLEWPTDLA VNPMDNSLYV LENNVILRIT
ENHQVSIIAG RPMHCQVPGI DYSLSKLAIH SALESASAIA ISHTGVLYIT ETDEKKINRL
RQVTTNGEIC LLAGAASDCD CKNDVNCNCY SGDDAYATDA ILNSPSSLAV APDGTIYIAD
LGNIRIRAVS KNKPVLNAFN QYEAASPGEQ ELYVFNADGI HQYTVSLVTG EYLYNFTYSA
DNDVTELIDN NGNSLKIRRD SSGMPRHLLM PDNQIITLTV GTNGGLKVVS TQNLELGLMT
YDGNTGLLAT KSDETGWTTF YDYDHEGRLT NVTRPTGVVT SLHREMEKSI TIDIENSNRD
DDVTVITNLS SVEASYTVVQ DQVRNSYQLC NNGTLRVMYA NGMGVSFHSE PHVLAGTITP
TIGRCNISLP MENGLNSIEW RLRKEQIKGK VTIFGRKLRV HGRNLLSIDY DRNIRTEKIY
DDHRKFTLRI IYDQVGRPFL WLPSSGLAAV NVSYFFNGRL AGLQRGAMSE RTDIDKQGRI
VSRMFADGKV WSYSYLDKSM VLLLQSQRQY IFEYDSSDRL HAVTMPSVAR HSMSTHTSIG
YIRNIYNPPE SNASVIFDYS DDGRILKTSF LGTGRQVFYK YGKLSKLSEI VYDSTAVTFG
YDETTGVLKM VSLQSGGFSC TIRYRKIGPL VDKQIYRFSE EGMVNARFDY TYHDNSFRIA
SIKPVISETP LPVDLYRYDE ISGKVEHFGK FGVIYYDINQ IITTAVMTLS KHFDTHGRIK
EVQYEMFRSL MYWMTVQYDS MGRVIKRELK LGPYANTTKY TYDYDGDGQL QSVAVNDRPT
WRYSYDLNGN LHLLNPGNSV RLMPLRYDLR DRITRLGDVQ YKIDDDGYLC QRGADIFEYN
SKGLLTRAYN KASGWSVQYR YDGVGRRASY KTNLGHHLQY FYSDLHNPTR ITHVYNHSNS
EITSLYYDLQ GHLFAMESSS GEEYYVASDN TGTPLAVFSI NGLMIKQLQY TAYGEIYYDS
NPDFQMVIGF HGGLYDPLTK LVHFTQRDYD VLAGRWTSPD YTMWKNVGKE PAPFNLYMFK
SNNPLSNELD LKNYVTDVKS WLVMFGFQLS NIIPGFPRAK MYFVPPPYEL SESQASENGQ
LITGVQQTTE RHNQAFMALE GQVISKKLHA NIREKAGHWF ATTTPIIGKG VMFAIKEGQV
TTGVSSVASE DSRKVASVLN NAYYLDKMHY SIEGKDTHYF VKIGSADGDL VTLGTTIGRK
VLESGVNVTV SQPTLLVNGR TRRFTNIEFQ YSTLLLSIRY GLTPDTLDEE KARVLDQARQ
RALGTAWAKE QQKARDGREG SRLWTEGEKQ QLLSTGRVQG YEGYYVLPVE QYPELADSSS
NIQFLRQNEM GKR
//