ID A0A2I2UE28_FELCA Unreviewed; 2067 AA.
AC A0A2I2UE28;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Myoferlin {ECO:0000313|Ensembl:ENSFCAP00000030724.2};
GN Name=MYOF {ECO:0000313|Ensembl:ENSFCAP00000030724.2,
GN ECO:0000313|VGNC:VGNC:63691};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000030724.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000030724.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000030724.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000030724.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000030724.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000030724.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000030724.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004483}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004483}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the ferlin family.
CC {ECO:0000256|ARBA:ARBA00007561}.
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DR EMBL; AANG04000273; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_019669108.1; XM_019813549.1.
DR Ensembl; ENSFCAT00000046685.3; ENSFCAP00000030724.2; ENSFCAG00000009934.6.
DR GeneID; 101087102; -.
DR CTD; 26509; -.
DR VGNC; VGNC:63691; MYOF.
DR GeneTree; ENSGT00940000154741; -.
DR OrthoDB; 991411at2759; -.
DR Proteomes; UP000011712; Chromosome D2.
DR Bgee; ENSFCAG00000009934; Expressed in uterus and 11 other cell types or tissues.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08373; C2A_Ferlin; 1.
DR CDD; cd04011; C2B_Ferlin; 1.
DR CDD; cd04018; C2C_Ferlin; 1.
DR CDD; cd04017; C2D_Ferlin; 1.
DR CDD; cd04037; C2E_Ferlin; 1.
DR CDD; cd08374; C2F_Ferlin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 6.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037726; C2A_Ferlin.
DR InterPro; IPR037720; C2B_Ferlin.
DR InterPro; IPR037722; C2C_Ferlin.
DR InterPro; IPR037723; C2D_Ferlin.
DR InterPro; IPR037724; C2E_Ferlin.
DR InterPro; IPR037725; C2F_Ferlin.
DR InterPro; IPR012968; FerIin_dom.
DR InterPro; IPR037721; Ferlin.
DR InterPro; IPR012560; Ferlin_A-domain.
DR InterPro; IPR012561; Ferlin_B-domain.
DR InterPro; IPR032362; Ferlin_C.
DR InterPro; IPR006614; Peroxin/Ferlin.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR PANTHER; PTHR12546:SF60; MISFIRE, ISOFORM F; 1.
DR Pfam; PF00168; C2; 7.
DR Pfam; PF08165; FerA; 1.
DR Pfam; PF08150; FerB; 1.
DR Pfam; PF08151; FerI; 1.
DR Pfam; PF16165; Ferlin_C; 1.
DR SMART; SM00239; C2; 7.
DR SMART; SM00694; DysFC; 2.
DR SMART; SM00693; DysFN; 2.
DR SMART; SM01200; FerA; 1.
DR SMART; SM01201; FerB; 1.
DR SMART; SM01202; FerI; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 7.
DR PROSITE; PS50004; C2; 7.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2032..2054
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..101
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 181..300
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 339..475
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1110..1238
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1269..1397
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1542..1660
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1778..1926
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 125..175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1983..2005
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1983..2000
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2067 AA; 235440 MW; C300DEEBEC2BEFA6 CRC64;
MLRVIVESAS NIPKTKFGKP DPIVSVIFKD EKKKTKKVDN ELNPVWNEIL EFDLRGIPLD
SSSSLTIVVK DFETIGQNKL IGTATVSLKD LIGDQNRSLP YKLISLLNER GQETGATIDL
VIGYVPPSAP HPNDPSGTST SVMEGEEEED GGDEDRLDNT VRTPGPKGAG GLVSEAQLAR
RLTKGKKSRR MLSSKPQDFQ IRVRVIEGRQ LSGNNIRPVV KVHVCGQTHR TRIKRGNNPF
FDELFFYNVH ITPSELMDEI ISIRVYNSHS LRADCLMGEF KIDVGFIYDE PGHAIMRKWL
LLNDPEDASS GAKGYMKVSM FILGTGDEPP AEKRDRDNDS DDVESNLLLP AGIALRWVTF
LLKIYRAEDI PQMDDAFSQT VKEIFGGNAD KKNLVDPFVE VSFAGKKVCT NIIEKNANPE
WNQVINLQIK FPSMCEKIKL TIYDWDRLTK NDVVGTTYLY LSKIAASGGE VEANTGETEV
GFVPTFGPCY LNLYGSPREY TGFPDPYDEL NTGKGEGVAY RGRILVELST FLEKTPPDKK
LEPISNDDLL VVEKYQRRRK YSLSAVFHSA TMLQDVGEAI QFEVSIGNYG NKFDTTCKPL
ASTTQYSRAV FDGNYYYYLP WAHTKPVVTL TSYWEDISHR LDAVNTLLTM AERLQSNTEA
LKSGIQGKIP ANQLAELWLK LIDEVIEDTR YTLPLMEGKA NVTILDTQIR KLRSRSLSQI
HEAAVRMRSE ATEVKSTLAE IEDWLDKLLQ LTEEPQNSMP DIIIWMIRGE KRLAYARIPA
HQVLYSTSGE NASGKYCGKT QTILLKYPRE NNHGPKVPVQ LRVNIWLGLS AVEKKFNSFA
EGTFTVFAEM YENQALMFGK WGTSGLVGRH KFSDVTGKIK LKREFFLPPK GWEWEGDWIV
DPERSLLTEA DAGHTEFTDE VYQNESRYPG GEWKAAEDTY TDANGDKAAS PSELTCPPGW
EWEDDAWVYD INRAVDEKGW EYGITIPPDN KPKSWVAAEK MYHTHRRRRL VRKRKKDLTQ
SASSTARAME EYEDREGWEY ASLIGWKFHW KQRSSDTFRR RRWRRKMAPS ETHGAAAIFK
LEGALGADTT EEGDEKSTEK QKYSATTVFG ANTPIVSCNF DRVYIYHLRC YIYQARNLMA
LDKDSFSDPY AHVSFLHRSK TTEIIHSTLN PTWDQTIIFD EIEIYGEPQT LLQNPPKVVI
ELFDNDQVGK DEFLGRSLCS PLVKLNSEMD ITPKLLWHPL MNGDKACGDV LVTAELILRH
KDGSNLPILP SQRAPNLYMV PQGIRPVVQL TAIEILAWGL RNMKNYQMAS ITSPSLIVEC
GGERVESVVI KNLKKTPNFP SSVLFMKVFL PKEELYMPPL VIKVIDHRQF GRKPVVGQCT
IDRLDRFRCD PYAGKEDLVP QLKASLLSTP PCRDVIIEIE DTKPLLASKC LSSMSTALSK
MASPTTVHLT EKEEEIVDWW SKFYASTGEH EKCGQYLQKG YSKLKVYDCE LEDVTEFGGL
TDFSDTFKLY RGKSDENEDP SVVGEFKGSF RIYSLSDDPS VPAPPRQFRE LPDSVPQECT
VRIYIVRGLE LQPQDNNGLC DPYIKITLGK KVIEDRDHYI PNTLNPVFGR MYELSCYLPQ
EKDLKISVYD YDTFTRDEKV GETIIDLENR FLSRFGSHCG IPEQYCVSGV NTWRDQLRPT
QLLQNVARFK GFPPPILSED GSRIRYGGRD YSLDEFEANK ILHQHLGAPD ERLALHILRT
QGLVPEHVET RTLHSTFQPN ISQGKLQMWV DVFPKSLGPP GPPFNITPRK AKKYYLRVII
WNTKDVLLDE KSITGEEMSD IYVKGWIPGS EENKQKTDVH YRSLDGEGNF NWRFVFPFDY
LPAEQLCIIA KKEHFWSIDQ TEFRVPPRLI IQIWDNDKFS LDDYLGFLEL DLHHTIIPAK
SSEKCNLDMV PDLKAMNPLK AKTASLFEQK SMKGWWPCFA DKDGSRVMAG KVEMTLEILN
EKEADERPAG KGRDEPNMNP KLDPPNRPET SFLWFTNPCK TMKFIVWRRF KWVIIGLLIL
LILLLFVAVL LYSLPNYLSM KIVRPNA
//
