ID A0A2I2UG55_FELCA Unreviewed; 3603 AA.
AC A0A2I2UG55;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=CUB and Sushi multiple domains 3 {ECO:0000313|Ensembl:ENSFCAP00000031502.1};
GN Name=CSMD3 {ECO:0000313|Ensembl:ENSFCAP00000031502.1,
GN ECO:0000313|VGNC:VGNC:61224};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000031502.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000031502.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000031502.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000031502.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000031502.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000031502.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000031502.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00302}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AANG04003518; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_019678604.1; XM_019823045.1.
DR Ensembl; ENSFCAT00000036784.3; ENSFCAP00000031502.1; ENSFCAG00000031602.4.
DR GeneID; 101092990; -.
DR CTD; 114788; -.
DR VGNC; VGNC:61224; CSMD3.
DR GeneTree; ENSGT00940000155549; -.
DR OrthoDB; 5400609at2759; -.
DR Proteomes; UP000011712; Chromosome F2.
DR Bgee; ENSFCAG00000031602; Expressed in brain and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00033; CCP; 28.
DR CDD; cd00041; CUB; 14.
DR Gene3D; 2.10.70.10; Complement Module, domain 1; 28.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 14.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR InterPro; IPR035976; Sushi/SCR/CCP_sf.
DR InterPro; IPR000436; Sushi_SCR_CCP_dom.
DR PANTHER; PTHR45656:SF4; PROTEIN BETA CHAIN, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR45656; PROTEIN CBR-CLEC-78; 1.
DR Pfam; PF00431; CUB; 14.
DR Pfam; PF00084; Sushi; 28.
DR SMART; SM00032; CCP; 28.
DR SMART; SM00042; CUB; 14.
DR SUPFAM; SSF57535; Complement control module/SCR domain; 28.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 14.
DR PROSITE; PS01180; CUB; 14.
DR PROSITE; PS50923; SUSHI; 28.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00302}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Sushi {ECO:0000256|PROSITE-ProRule:PRU00302};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 44..63
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 3527..3548
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 65..173
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 176..237
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 241..345
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 380..441
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 444..555
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 558..615
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 617..725
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 728..789
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 791..899
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 904..961
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 963..1073
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1076..1135
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1137..1245
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1248..1308
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1310..1419
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1422..1482
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1484..1592
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1595..1656
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1658..1766
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1772..1833
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 1835..1943
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 1946..2005
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2007..2115
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2118..2177
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2179..2290
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2289..2350
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2352..2463
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 2463..2525
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2526..2587
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2588..2652
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2653..2710
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2711..2768
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2769..2826
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2827..2888
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2889..2946
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 2950..3007
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3008..3066
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3067..3126
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3127..3184
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3185..3242
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3246..3304
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT DOMAIN 3305..3364
FT /note="Sushi"
FT /evidence="ECO:0000259|PROSITE:PS50923"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 586..613
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 932..959
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 1310..1337
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
FT DISULFID 2681..2708
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2739..2766
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2797..2824
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2859..2886
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2917..2944
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 2978..3005
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3037..3064
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3155..3182
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3213..3240
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
FT DISULFID 3275..3302
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00302"
SQ SEQUENCE 3603 AA; 394590 MW; 116FCCB81EEBE9DD CRC64;
MKGIRKGESR AKESKPREPG TRRCAKCGRL DFILMKKMGI KSGFTFWNLV FLLTVSCVKG
FIYTCGGTLK GLNGTIESPG FPYGYPNGAN CTWVIIAEER NRIQIVFQSF ALEEEYDYLS
LYDGHPHPTN FRTRLTGFHL PPPVTSTKSV FSLRLTSDFA VSAHGFKVYY EELQSSSCGN
PGVPPKGVLY GTRFDVGDKI RYSCVTGYIL DGHPQLTCIA NSVNTASWDF PVPICRAEDA
CGGTMRGSSG IISSPSFPNE YHNNADCTWT IVAEPGDTIS LIFTDFQMEE KYDYLEIEGS
EPPTIWLSGM NIPPPIISNK NWLRLHFVTD SNHRYRGFSA PYQVKKAIDF KSRGFKLFPG
KDNSNKFSIL NEGGIKTASN LCPDPGEPEN GKRVGSDFSL GSTVQFSCDE DYVLQGAKSI
TCQRIAEVFA AWSDHRPVCK VKTCGSNLQG PSGTFTSPNF PFQYDSNAQC VWVITAVNTN
KVIQINFEEF DLEIGYDTLT IGDGGEVGDP RTVLQVLTGS FVPDLIVSMS SQMWLHLQTD
ESVGSVGFKV NYKEIEKESC GDPGTPLYGI REGDGFSNRD VLRFECQFGF ELIGEKSIVC
QENNQWSANI PICIFPCLSN FTAPMGTVLS PDYPEGYGNN LNCIWTIISD PGSRIHLSFN
DFDLESQFDF LAVKDGDSPD SPILGTFTGA EVPSHLTSNS HILRLEFQAD HSMSGRGFNI
TYNTFGHNEC PDPGIPINAR RFGDNFQLGS SISVICEEGF IKTQGTETIT CILMDGKVMW
SGPIPRCGAP CGGHFSAPSG LILSPGWPGY YKDSLNCEWV IEAEPGHSIK ITFERFQTEL
NYDVLEVHDG PNLLSPLLGS YNGTQVPQFL FSSSNFIYLL FTTDNSRSNN GFKIHYESVT
VNTYSCLDPG IPVHGRRYGH DFSIGSTVSF SCDPGYRLSH EEPLLCEKNH WWSHPLPTCD
ALCGGDVRGP SGTILSPGYP EFYPNSLNCT WTVDVTHGKG VQFNFHTFHL EDHHDYLLIT
ENGSFTQPLA RLTGSELPST INAGLYGNFR AQLRFISDFS ISYEGFNITF SEYNLEPCED
PGIPQYGNRI GFSFGVGDTL TFSCSSGYRL EGTSEIICLG GGRRVWSAPL PRCVAECGAS
ATNNEGILLS PNYPLNYENN HECIYSIQVQ AGKGINISAR TFHLAQGDVL KIYDGKDKTT
HLLGAFTGAS MRGLTLSSTS NQLWLEFNSD SEGTDEGFQL VYTSFELSHC EDPGIPQFGY
KISDQGHFAG STIIYGCNPG YTLHGSSLLK CMTGERRAWD YPLPSCIAEC GGRFKGESSG
RILSPGYPFP YDNNLRCMWM IEVDPGNIVS LQFLAFDTEA SHDILRVWDG PPENEMLLKE
ISGSLIPEGI HSTLNIVTIQ FDTDFYISKS GFAIQFSSSV ATACRDPGVP MNGTRNGDGR
EPGDTVVFQC DPGYELQGEE RITCIQVENR YFWQPSPPVC IAPCGGNLTG SSGFILSPNF
PHPYPHSRDC DWTITVNTDY VISLAFISFS IEPNYDFLYI YDGPDSNSPL IGSFQDSKLP
ERIESSSNTM HLAFRSDGSV SYTGFHLEYK AKLRESCFDP GNIMNGTRLG MDYKLGSTVT
YYCDAGYVLQ GYSTLTCIMG DDGRPGWNRA LPSCHAPCGS RSTGSEGTVL SPNYPKNYSV
GHNCVYSIAV PKEFVVFGQF VFFQTSLHDV VEVYDGPTQQ SSLLSSLSGS HSGESLPLSS
GNQITIRFTS VGPITAKGFH FVYQAVPRTS STQCSSVPEP RFGRRIGNEF AVGSLVLFEC
NPGYILHGSI AIRCDTVPNS LAQWNDSLPT CIVPCGGVLT KRKGTILSPG YPEPYDNNLN
CVWKITVPEG AGIQVQVISF ATEHNWDSLD FYDGGDNNAP RLGSYSGTTI PHLLNSTSNN
LYLNFQSDIS VSAAGFHLEY TAIGLDSCPE PQTPSSGMKI GDRYMVGDVV SFQCDQGYSL
QGHSHITCMP GPVRRWNYPI PICLAQCGGA MSDFSGVILS PGFPGNYPSS LDCTWTIKLP
VGFGVHLQFV NFSTETIHDY LEVRSGSSET STVIGRLSGP QIPSSLFSTT HETSLYFHSD
YSQNKQGFHI VYQAYQLQSC PDPRPFRNGF VIGNDFTVGQ TISFECFPGY TLIGNSALTC
LHGVSRNWNH PLPRCEALCG GNITAMNGTI YSPGYPDEYP NFQDCFWLVR VPPGNGIYIN
FTVLQTEPIY DFITVWDGPD QNSPQIGQFS GNTALESVYS TSNQILIKFH SDFTTSGFFV
LSYHAYQLRV CQPPPPVPNA EILTEDDEFE IGDIIRYQCL PGFTLVGNAI LTCRLGERLQ
MDGAPPVCQV LCPANELRLD STGVILSPGY PDSYPNLQMC AWSISVEKGY NISMFVEFFQ
TEKEFDVLQV YDGPNIQSPV LISLSGDYSS PFNVTSNGHE VFLQWSADHG NNKKGFRIRY
IAFYCSTPES PPHGYIISQT GGQLNSVVRW ACDRGFRLVG KSSAVCRKSS YGYHAWDAPV
PACQAISCGI PKAPTNGGIL TTDYLVGTRV TYFCNDGYRL SSKELTTAIC QSDGTWSHHN
KTPRCVVVTC PSINSFTLEH GRWRIVNGSH YEYKTKVVFS CDPGYHGLGP ASIECLPNGT
WSWRNERPYC QIISCGELPT PPNGNKIGTQ TSYGSTAIFT CDSGFMLVGS AVRECLSSGL
WSGSETRCLA GHCGIPELIV NGQVIGENYG YRDTVVYQCN PGFRLIGSSV RICQQDHNWS
GQLPSCVPVS CGHPGSPIYG RTSGNGFNFN DVVTFSCNIG YVMQGPTKAQ CQANRQWSHP
PPVCKVVNCS DPGIPANSKR ESKIEHGNFT YGTVVFYDCN PGYFLFGSSV LICQPNGQWD
KPLPECIMID CGHPGVPPNA VLSGEKFTFG STVHYSCTGK RTLLGQSSRT CQLNGHWSGA
QPHCSGDATG TCGDPGTPGH GSRQESDFRT KSSVRFACDI GYILHGSEER TCLANGSWTG
RQPECKAIQC GNPGTTANGK VFRIDGTTFS SSVIYSCMEG YILSGPSVRQ CTANGTWSGS
LPNCTIISCG DPGIPANGLR YGDDYVVGQN VSYMCQPGYT MEFNGSRIRT CTTNGTWSGI
MPTCRAVTCS TPPQISNGRL EGTNFDWGFS ISYICSPGYE LSFPAVLTCV GNGTWSGEVP
QCLPKFCGDP GIPAQGKREG KSFIYQSEVS FSCNSPFILV GSSTRICQAD GTWSGSSPHC
IEPTRTSCEN PGVPRHGSQN NTFGFQVGSV VQFHCKKGHL LQGSTTRTCL PDLTWSGIQP
ECIPHSCKQP ETPAHANVVG MDLPSHGYTL IYTCQPGFFL AGGTEHRVCR SDNTWTGKVP
VCEAGSKILV KDPRPALGTP SPKLSVPDDV FAQNYIWKGS YNFKGRKQPM TLTVTSFNAS
TGRVNATLSN SNMELLLSGV YKSQEARLML HIYLIKVPTH ASVKKMKEDN WAMDGFVSAE
PDGATYVFQG FIQGKDYGQF GLQRLGLNMS EGSNSSNQPH GTNSSSVAIA ILVPFFALIF
AGFGFYLYKQ RTAPKTQYTG CSVHENNNGQ AAFENPMYDT NAKSAEGKAV RFDPNLNTVC
TMV
//
