ID A0A2I2UHJ4_FELCA Unreviewed; 872 AA.
AC A0A2I2UHJ4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Interacts with SUPT6H, CTD assembly factor 1 {ECO:0000313|Ensembl:ENSFCAP00000031799.3};
GN Name=IWS1 {ECO:0000313|Ensembl:ENSFCAP00000031799.3,
GN ECO:0000313|VGNC:VGNC:62990};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000031799.3, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000031799.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000031799.3,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000031799.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000031799.3,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000031799.3}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000031799.3};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00649}.
CC -!- SIMILARITY: Belongs to the IWS1 family.
CC {ECO:0000256|ARBA:ARBA00037992}.
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DR EMBL; AANG04001482; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2UHJ4; -.
DR Ensembl; ENSFCAT00000037913.3; ENSFCAP00000031799.3; ENSFCAG00000009026.6.
DR VGNC; VGNC:62990; IWS1.
DR GeneTree; ENSGT00720000108834; -.
DR Proteomes; UP000011712; Chromosome C1.
DR Bgee; ENSFCAG00000009026; Expressed in embryonic head and 10 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR Gene3D; 1.20.930.10; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR InterPro; IPR035441; TFIIS/LEDGF_dom_sf.
DR InterPro; IPR017923; TFIIS_N.
DR PANTHER; PTHR46010; PROTEIN IWS1 HOMOLOG; 1.
DR PANTHER; PTHR46010:SF1; PROTEIN IWS1 HOMOLOG; 1.
DR Pfam; PF08711; Med26; 1.
DR SUPFAM; SSF47676; Conserved domain common to transcription factors TFIIS, elongin A, CRSP70; 1.
DR PROSITE; PS51319; TFIIS_N; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00649}; Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 668..746
FT /note="TFIIS N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51319"
FT REGION 1..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 750..782
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 30..71
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 84..183
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..517
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..547
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 548..574
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..768
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 872 AA; 98160 MW; 66D4CE10C3BA0746 CRC64;
MDSEYYSGDQ SDDGGATPVQ DERDSGSDVE DDVNEQHSGS DTGSVERHSE NEPSDREDGL
NKRHHVTDSE NDDPSNLNAS DSESEELQRQ KDSDSESEEH AEPVASDSEN EDTHQRASDS
ESEETRKLPV SDSENEDLLN GHATDSENED ARKHPASDSE MEELPKSPAS DSETEDVLKP
QISDSESEEP PQHQASDSEN EELPKPRISD SESEELPKPR VSDSESEEPQ RTQASDSENE
ELPKPRVSDS ESEDPPRHQA SDSENEELPK PRVSDSESEG PPRHQASDSE NEELPKPRVS
DSESEGPPRH QASDSENEEL PKPRVSDSES EDPPRNQASD SENEELPKPR VSDSESEEPQ
KGPASDSETE DASRHKEKPE SDEDSDGENK GEDAEMQKDS FRSDSHIDRK RIQSSDSEEE
EPKRPKIDSD EDEEKVGEEE KVAKRKAAVL SDSEDEEKAS AKKSRVVSDA DDSDSDVISD
KPGKREKTLA SDSEEEAGKE ELSDKKNEEK DLFGSDSESG NEEENLIADI FGESGDEEEE
EFTGFNQEDL EEEKSETQVK EAEDSDSDDN IKRGKHMDFL SDFEMMLQRK KSMSGKRRRN
RDGGTFISDA DDVVSAMIVK MNEAAEEDRQ LNNQKKPALK KLTLLPTVVM HLKKQDLKET
FIDSGVMSAI KEWLSPLPDR SLPALKIREE LLKILQELPS VSQETLKHSG IGRAVMYLYK
HPKESRSNKD MAGKLINEWS RPIFGLTSNY KGMTREEREQ RDLEQMPQRR RMNSTGGQTP
RRDLEKVLTG EEKALRPGDP GFCARARVPM PSNKDYVVRP KWNVEMESSR PGILKKGLSR
LEKHKRRFAE QKRLSKVHRA VKFSIEGNRM PL
//
