ID A0A2I2UHS5_FELCA Unreviewed; 634 AA.
AC A0A2I2UHS5;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 2.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=ASH2 like, histone lysine methyltransferase complex subunit {ECO:0000313|Ensembl:ENSFCAP00000032050.2};
GN Name=ASH2L {ECO:0000313|Ensembl:ENSFCAP00000032050.2,
GN ECO:0000313|VGNC:VGNC:68340};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000032050.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000032050.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000032050.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000032050.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000032050.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000032050.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000032050.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AANG04001605; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2UHS5; -.
DR STRING; 9685.ENSFCAP00000032050; -.
DR Ensembl; ENSFCAT00000039588.3; ENSFCAP00000032050.2; ENSFCAG00000013603.6.
DR VGNC; VGNC:68340; ASH2L.
DR GeneTree; ENSGT00390000010474; -.
DR InParanoid; A0A2I2UHS5; -.
DR OMA; CATCSRW; -.
DR OrthoDB; 5479497at2759; -.
DR Proteomes; UP000011712; Chromosome B1.
DR Bgee; ENSFCAG00000013603; Expressed in testis and 9 other cell types or tissues.
DR GO; GO:0071339; C:MLL1 complex; IEA:Ensembl.
DR GO; GO:0044666; C:MLL3/4 complex; IEA:Ensembl.
DR GO; GO:0048188; C:Set1C/COMPASS complex; IBA:GO_Central.
DR GO; GO:0008013; F:beta-catenin binding; IEA:Ensembl.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IBA:GO_Central.
DR GO; GO:0006974; P:DNA damage response; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0043627; P:response to estrogen; IEA:Ensembl.
DR GO; GO:0045815; P:transcription initiation-coupled chromatin remodeling; IEA:Ensembl.
DR CDD; cd15583; PHD_ash2p_like; 1.
DR CDD; cd12872; SPRY_Ash2; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.90.980.20; -; 1.
DR InterPro; IPR037353; ASH2.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR10598; SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2; 1.
DR PANTHER; PTHR10598:SF0; SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2; 1.
DR Pfam; PF21198; ASH2L-like_WH; 1.
DR Pfam; PF21257; PHD_ash2p_like; 1.
DR Pfam; PF00622; SPRY; 1.
DR SMART; SM00449; SPRY; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
PE 4: Predicted;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 366..589
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 1..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 262..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 72..86
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 634 AA; 69170 MW; 8970A1B7BF579C86 CRC64;
MAAAGTGPGP GVDAGPGPAA AANATVAEEG ETKPVVAVAT APAGEGTSVA PAAEPGSGEA
ESGDANSVDV GGGLETESSN GKDTLEGAGD TSEVMDTQAG SVDEENGRQL GEVELQCGIC
TKWFTADTFG IDTSSCLPFM TNYSFHCNVC HHSGNTYFLR KQANLKEMCL SALANLTWQS
RTQDEHPKTM FSKDKDIIPF IDKYWECMTT RQRPGKMTWP NNIVKTMSKE RDVFLVKEHP
DPGSKDPEED YPKFGLLDQD LSNIGPAYDN QKQSSAVSTS GNLNGGVSFG GGIAAGSSGK
GRGAKRKQQD GGTAGTTKKA RSDPLFSAQR LPPHGYPLEH PFNKDGYRYI LAEPDPHAPD
PEKLELDCWA GKPIPGDLYR ACLYERVLLA LHDRAPQLKI SDDRLTVVGE KGYSMVRASH
GVRKGAWYFE ITVDEMPPDT AARLGWSQPL GNLQAPLGYD KFSYSWRSKK GTKFHQSIGK
HYSSGYGQGD VLGFYINLPE DTETAKSLPD TYKDKALIKF KSYLYFEEKD FVDKAEKSLK
QTPHSEIIFY KNGVNQGVAY KDIFEGVYFP AISLYKSCTV SINFGPCFKY PPKDLTYRPM
SDMGWGAVVE HTLADVLYHV ETEVDGRRSP PWEP
//