ID A0A2I2UHU2_FELCA Unreviewed; 685 AA.
AC A0A2I2UHU2;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Rho related BTB domain containing 2 {ECO:0000313|Ensembl:ENSFCAP00000031899.2};
GN Name=RHOBTB2 {ECO:0000313|Ensembl:ENSFCAP00000031899.2,
GN ECO:0000313|VGNC:VGNC:64614};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000031899.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000031899.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000031899.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000031899.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000031899.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000031899.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000031899.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04002583; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2UHU2; -.
DR Ensembl; ENSFCAT00000046940.3; ENSFCAP00000031899.2; ENSFCAG00000005670.5.
DR VGNC; VGNC:64614; RHOBTB2.
DR GeneTree; ENSGT00940000158918; -.
DR Proteomes; UP000011712; Chromosome B1.
DR Bgee; ENSFCAG00000005670; Expressed in prefrontal cortex and 9 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd18356; BTB1_POZ_RHOBTB2; 1.
DR CDD; cd01873; RhoBTB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR003578; Small_GTPase_Rho.
DR PANTHER; PTHR24072; RHO FAMILY GTPASE; 1.
DR PANTHER; PTHR24072:SF137; RHO-RELATED BTB DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00651; BTB; 3.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00225; BTB; 2.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54695; POZ domain; 2.
DR PROSITE; PS50097; BTB; 2.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
DR PROSITE; PS51420; RHO; 1.
PE 4: Predicted;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 657..677
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 275..452
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT DOMAIN 510..577
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT REGION 313..341
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 685 AA; 77250 MW; F85FD2D656225949 CRC64;
MLLFLRSQLM DSDMDYERPN VETIKCVVVG DNAVGKTRLI CARACNATLT QYQLLATHVP
TVWAIDQYRV CQEVLERSRD VVDDVSVSLR LWDTFGDHHK DRRFAYGRSD VVVLCFSIAN
PNSLHHVKTM WYPEIKHFCP RAPVILVGCQ LDLRYADLEA VNRARRPLAR PIKPNEILPP
EKGREVAKEL GIPYYETSVV AQFGIKDVFD NAIRAALISR RHLQFWKSHL RNVQRPLLQA
PFLPPKPPPP IIVVPDPPSS SEECPAHLLE DPLCADVILV LQERVRIFAH KIYLSTSSSK
FYDLFLMDLS EGELGGPSGP GGPRPEDHRG HPDHHYHHHH HHHHGRDFLL RAASFDVCES
VEEGGGSGPA GLRASTSDGI LRGNGTGYLP GRGRVLSSWS RAFVSIQEEM AEDPLTYKSR
LMVVVKMDNS IQPGPFRAVL KYLYTGELDE NERDLMHIAH IAELLEVFDL RMMVANILNN
EAFMNQEITK AFHVRRTNRV KECLAKGTFS DVTFILDDGT ISAHKPLLIS SCDWMAAMFG
GPFVESSTRE VVFPYTSKSC MRAVLEYLYT GMFTSSPDLD DMKLIILANR LCLPHLVALT
GSLRRVLGPT VLSPADDSAG CSPSWVSLWQ AQVKRNRTQF LTPHPLLGPF PPPLPSFFSL
LFLLLFLLLL FHLRFLVLPE TDNKH
//
