ID A0A2I2UL09_FELCA Unreviewed; 198 AA.
AC A0A2I2UL09;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Fibroblast growth factor {ECO:0000256|RuleBase:RU049442};
DE Short=FGF {ECO:0000256|RuleBase:RU049442};
GN Name=FGF5 {ECO:0000313|Ensembl:ENSFCAP00000033028.2,
GN ECO:0000313|VGNC:VGNC:62253};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000033028.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000033028.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000033028.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000033028.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000033028.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000033028.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000033028.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Plays an important role in the regulation of cell
CC proliferation and cell differentiation. Required for normal regulation
CC of the hair growth cycle. Functions as an inhibitor of hair elongation
CC by promoting progression from anagen, the growth phase of the hair
CC follicle, into catagen the apoptosis-induced regression phase.
CC {ECO:0000256|ARBA:ARBA00025188}.
CC -!- SUBUNIT: Interacts with FGFR1 and FGFR2. Affinity between fibroblast
CC growth factors (FGFs) and their receptors is increased by heparan
CC sulfate glycosaminoglycans that function as coreceptors.
CC {ECO:0000256|ARBA:ARBA00026062}.
CC -!- SIMILARITY: Belongs to the heparin-binding growth factors family.
CC {ECO:0000256|ARBA:ARBA00007936, ECO:0000256|RuleBase:RU049442}.
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DR EMBL; AANG04001605; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_019683698.1; XM_019828139.1.
DR AlphaFoldDB; A0A2I2UL09; -.
DR Ensembl; ENSFCAT00000044244.3; ENSFCAP00000033028.2; ENSFCAG00000029635.4.
DR VGNC; VGNC:62253; FGF5.
DR GeneTree; ENSGT00940000158449; -.
DR OMA; FSHISAW; -.
DR Proteomes; UP000011712; Chromosome B1.
DR Bgee; ENSFCAG00000029635; Expressed in zone of skin and 3 other cell types or tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR Gene3D; 2.80.10.50; -; 1.
DR InterPro; IPR002209; Fibroblast_GF_fam.
DR InterPro; IPR008996; IL1/FGF.
DR PANTHER; PTHR11486; FIBROBLAST GROWTH FACTOR; 1.
DR PANTHER; PTHR11486:SF23; FIBROBLAST GROWTH FACTOR 5; 1.
DR Pfam; PF00167; FGF; 1.
DR PRINTS; PR00263; HBGFFGF.
DR SMART; SM00442; FGF; 1.
DR SUPFAM; SSF50353; Cytokine; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|RuleBase:RU049442}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|RuleBase:RU049442"
FT CHAIN 21..198
FT /note="Fibroblast growth factor"
FT /evidence="ECO:0000256|RuleBase:RU049442"
FT /id="PRO_5023976673"
FT REGION 26..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..83
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 198 AA; 21502 MW; EEE9C43A35C37D97 CRC64;
MSLSFLLLLF LSHLILSAWA HGEKHLAPKG QPGPAATGRN PAGASSSRSS RGTTSSSSSS
VSSSHSASLG NQGSGLEQSS FQWSPSGRRT GSLYCRVGIG FHLQIYPDGK VNGSHEANML
SILEIFAVSQ GIVGIRGVFS NKFLAMSKKG KLHASVCYLY GNPHRAPFWI YMRSTFRHFL
RLQEPLISRV SFFSRNLI
//
