ID A0A2I2ULM7_FELCA Unreviewed; 2515 AA.
AC A0A2I2ULM7;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=Nuclear receptor corepressor 1 {ECO:0000256|ARBA:ARBA00044171};
GN Name=NCOR1 {ECO:0000313|Ensembl:ENSFCAP00000033436.1,
GN ECO:0000313|VGNC:VGNC:97523};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000033436.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000033436.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000033436.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000033436.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000033436.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000033436.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000033436.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the N-CoR nuclear receptor corepressors family.
CC {ECO:0000256|ARBA:ARBA00010097}.
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DR EMBL; AANG04000740; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_019672776.1; XM_019817217.1.
DR STRING; 9685.ENSFCAP00000033436; -.
DR Ensembl; ENSFCAT00000036553.3; ENSFCAP00000033436.1; ENSFCAG00000009998.6.
DR VGNC; VGNC:97523; NCOR1.
DR GeneTree; ENSGT00940000155093; -.
DR InParanoid; A0A2I2ULM7; -.
DR OMA; AVIPPMX; -.
DR OrthoDB; 5482374at2759; -.
DR Proteomes; UP000011712; Chromosome E1.
DR Bgee; ENSFCAG00000009998; Expressed in uterus and 10 other cell types or tissues.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0000118; C:histone deacetylase complex; IEA:Ensembl.
DR GO; GO:0072686; C:mitotic spindle; IEA:Ensembl.
DR GO; GO:0017053; C:transcription repressor complex; IEA:Ensembl.
DR GO; GO:0042826; F:histone deacetylase binding; IEA:Ensembl.
DR GO; GO:0046966; F:nuclear thyroid hormone receptor binding; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR GO; GO:0060766; P:negative regulation of androgen receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0045922; P:negative regulation of fatty acid metabolic process; IEA:Ensembl.
DR GO; GO:0045820; P:negative regulation of glycolytic process; IEA:Ensembl.
DR GO; GO:0046329; P:negative regulation of JNK cascade; IEA:Ensembl.
DR GO; GO:1902894; P:negative regulation of miRNA transcription; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0051225; P:spindle assembly; IEA:Ensembl.
DR CDD; cd00167; SANT; 2.
DR Gene3D; 1.20.5.430; -; 1.
DR Gene3D; 1.20.58.1880; -; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR031557; N-CoR_GPS2_interact.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR017884; SANT_dom.
DR PANTHER; PTHR13992; NUCLEAR RECEPTOR CO-REPRESSOR RELATED NCOR; 1.
DR PANTHER; PTHR13992:SF5; NUCLEAR RECEPTOR COREPRESSOR 1; 1.
DR Pfam; PF15784; GPS2_interact; 1.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 2.
DR PROSITE; PS51294; HTH_MYB; 1.
DR PROSITE; PS50090; MYB_LIKE; 1.
DR PROSITE; PS51293; SANT; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 444..495
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT DOMAIN 630..684
FT /note="HTH myb-type"
FT /evidence="ECO:0000259|PROSITE:PS51294"
FT DOMAIN 630..680
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT DOMAIN 633..684
FT /note="SANT"
FT /evidence="ECO:0000259|PROSITE:PS51293"
FT REGION 1..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..177
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 206..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 504..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 687..940
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1106..1127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1522..1541
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1551..1619
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1773..1842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1930..1949
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1961..1998
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2019..2042
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2075..2116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2142..2231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2364..2515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 47..69
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..115
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..177
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 519..580
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 615..630
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 687..708
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 722..741
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 762..815
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 856..883
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 893..909
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1564..1611
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1791..1808
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1983..1998
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2096..2116
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2142..2190
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2200..2217
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2422..2436
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2446..2491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2515 AA; 277013 MW; 3F466249EC3A3E2C CRC64;
MSSSGYPPNQ GAFSTEQSRY PPHSVQYTFP STRHQQEFAV PDYRSSHLEV SQASQLLQQQ
QQQQLRRRPS LLSEFHPGSD RPQERRTGYE QFHPGPSPVD HDSLESKRPR LEQVSDSHFQ
RVSAAVLPLV HTLPEGLRSS ADAKKDPAFG GKHEAPSSPI SGQPCGDDQN ASPSKLSKEE
LIQSMDRVDR EIAKVEQQIL KLKKKQQQLE EEAAKPPEPE KPVSPPPVEQ KHRSIVQIIY
DENRKKAEEA HKIFEGLGPK VELPLYNQPS DTKVYHENIK TGVPARRMMK NQVMRKKLIL
FFKRRNHARK QREQKICQRY DQLMEAWEKK VDRIENNPRR KAKESKTREY YEKQFPEIRK
QREQQERFQR VGQRGAGLSA TIARSEHEIS EIIDGLSEQE NNEKQMRQLS VIPPMMFDAE
QRRVKFINMN GLMEDPMKVY KDRQFMNVWT DHEKEIFKDK FIQHPKNFGL IASYLERKSV
PDCVLYYYLT KKNENYKALV RRNYGKRRGR NQQQIARPSQ EEKVEEKEED KAEKTEKKEE
EKKDEEEKDD KEDSKENTKE KDKTEGATEE TEEREQATPR GRKTANSQGR RKGRITRSMT
NEAAAASAAA AAATEEPPPP LPPPPEPIST EPVETSRWTE EEMEVAKKGL VEHGRNWAAI
AKMVGTKSEA QCKNFYFNYK RRHNLDNLLQ QHKQKTSRKP REERDVSQCE SVASTVSAQE
DEDIEASNEE ENPEDSEGAE NSSDTESAPS PSPVEAVKPG EDSTENASSR GNTEPVAELG
STSEPAPGAS PSSAVPSTKP VENESAETQA NDSITVEAAE PMDVDRQEPS AEVTSVLDLP
ATTRTDSVDV DMRVPENNPS KVEGDTKERD LERAGEKTEP GDEDLVGAQQ IGAQRPEPQS
DNDSSATCSA DEDVDGEPER QRMFPMDSKP SLLNPPGSIL VSSPIKPNPL DLPQLQHRAA
VIPPMVSCTP CNIPIGTPVS GYALYQRHIK AMHESALLEE QRQRQEQIDL ECRSSTSPCG
TSKSPNREWE GKSVAYMPYA EVTRALEQEA QMHSTAARSA SPCRLSPREV SKAAPQPMSA
ARYSVPPVLQ PAPHQVITNL PEAVRLPTTR PTRPPPPLIP SSKTTVASEK PSFILGGSIS
QGTPGTYLTS HNQTSYTQET AKPSVGSISL GLPRQQESAK SATVPYIKQE EFSPRSQNSQ
PEGLLVRAQH EGVVRGTPGA IQEGSITRGT PTSKISLEGI PSLRGSITQG TPALSQAGIP
AEALVKGSIS RMPIEENSPE KGREEAASKG HVIYEGKSGH ILSYDNIKNA REGTRSPRTA
HEISLKRSYE SVEGNIKQGL SMRESPVSAP LEGLICRALP RGSPHSDLKE RTVLSGSIMQ
GTPRATTESF EDGLKYPKQI KRESPPIRAF EGAITKGKPY DGITTIKEMG RSIHEIPRQD
ILTQESRKTP EVVQSTRPII EGSISQGTPI KFDSNSGQSA IKHNVKSLIT GPNKLPRGMP
PLEIVPENIK VVERGKYEDV KAGEPVRSRH TSVVSSGPSV LRSTLHEAPK AQLSPGIYDD
SSARRTPVSY QSTMSRGSPM MNRTSDVTIS SSKSTNHERK STLTPTQRES IPAKSPVPGV
DPVVSHSPFD PHHRGSTTGE VYRSHLPTHL DPAMPFHRAL DPAAAAYLFQ RQLSPTPAYP
SQYQLYAMEN TRQTILNDYI TSQQMQVNLR PDVARGLSPR EQQLGLPYPA TRGIIDLTNM
PPAILVPHPG GTSTPPMDRI TYIPGTQITF PPRPYNSASM SPGHSTHLAA AASAEREREK
ERERIAAASS DLYLRSGSEQ PGRPGSHGYV RSPSPSVRAQ EPMLQQRPSV FQGTNGTSVI
TPLDPSAQLR IMPLPAGGPS ISQGLPASRY STAADALAAL VDAAASAPQM EVSKTKESKH
EASRLEETLR SRSAAVSEQQ QLEQKSLEAE KRSVQCLYTS AAFPSGKPQP HSSVVYSEAG
KDKGPPPKSR YEEELRTRGK TTITAANFID VIITRQIASD KDARERGSQS SDSSSSLSSH
RYEAPGDAIE VISPASSPAP PQEKLQAYQP EVVKANQAES EASRPYEGPL HHYRPQQESL
SPQQQLPPSS QADGVGQVPR THRLITLADH ICQIITQDFA RNQVSSQPPQ QPPTSTFQNS
PSALVSTPVR TKTSNRYSPE SQSQSVHHQR PGPRVSPENL VDKSRGRPGK SPERSHVSSE
SYEPISPPQV PVVHEKQDSV LLLSQRGAEP AEQRNDSRSP GSISYLPSFF TKLENTSPMV
KSKKQEIFRK LNSSGGGDSD MAAAQPGTEI FNLPAVTTSG SVSSRGHSFA DPASNLGLED
IIRKALMGSF DDKVEEHGVV MSQPVGVVPG GASTSVVPSG ETRREEGDPS PHSGGVCKPK
LISKSNSRKS KSPIPGQGFL GTERPSSVSS VHSEGDYHRQ TPGWAWEDRP SSTGSTQFPY
NPLTMRMLSS TPPTPIACAP SSVNQAAPHQ QSRIWEREPA PLLSAQYETL SDSDD
//
