ID A0A2I2UNT3_FELCA Unreviewed; 515 AA.
AC A0A2I2UNT3;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=G protein-coupled receptor 176 {ECO:0000313|Ensembl:ENSFCAP00000034085.1};
GN Name=GPR176 {ECO:0000313|Ensembl:ENSFCAP00000034085.1,
GN ECO:0000313|VGNC:VGNC:80962};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000034085.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000034085.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000034085.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000034085.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000034085.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000034085.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000034085.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AANG04001761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003987332.1; XM_003987283.4.
DR AlphaFoldDB; A0A2I2UNT3; -.
DR STRING; 9685.ENSFCAP00000034085; -.
DR PaxDb; 9685-ENSFCAP00000022157; -.
DR Ensembl; ENSFCAT00000044218.2; ENSFCAP00000034085.1; ENSFCAG00000038334.2.
DR GeneID; 101092188; -.
DR KEGG; fca:101092188; -.
DR CTD; 11245; -.
DR VGNC; VGNC:80962; GPR176.
DR GeneTree; ENSGT00950000182998; -.
DR InParanoid; A0A2I2UNT3; -.
DR OMA; VTDIYAM; -.
DR OrthoDB; 5307295at2759; -.
DR Proteomes; UP000011712; Chromosome B3.
DR Bgee; ENSFCAG00000038334; Expressed in prefrontal cortex and 9 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0048512; P:circadian behavior; IEA:Ensembl.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR CDD; cd15006; 7tmA_GPR176; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR043523; GPCR_176_Rhodpsn_7TM.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR22752; G PROTEIN-COUPLED RECEPTOR; 1.
DR PANTHER; PTHR22752:SF1; G-PROTEIN COUPLED RECEPTOR 176; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 4: Predicted;
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023040};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Transducer {ECO:0000256|ARBA:ARBA00023040};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 47..67
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 79..102
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 122..141
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 162..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 268..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 300..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 58..320
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 515 AA; 56878 MW; 77A0CC740F6CE05F CRC64;
MGHNGSWISR NASEPRNASG AEAGGANRSA LGELGEVQLY RQFTTTVQVV IFIGSLLGNF
MVLWSTCRTT VFKSVTNRFI KNLACSGICA SLVCVPFDII LSTSPHCCWW IYTMLFCKVV
KFLHKVFCSV TILSFPAIAL DRYYSVLYPL ERKISDAKSR ELVMYIWAHA VVASIPVFAV
TNVADIYAMS TCTEVWSNSL GHLVYVLIYN ITTVIVPVAV VFLFLILIRR ALSASQKKKV
IIAALRTPQN TISIPYASQR EAELHATLLS MVMVFILCSV PYATLVVYQT VLNVPDTSVF
LLLTAIWLPK VSLLANPVLF LTVNKSVRKC LVGTLIQLHH RYSRRNVVGA AGGVADASLE
PSLRSGSQLL EMFHIGQQQI FKPTEDEEES EAKYTGSADL QAKEILSTCL EGEGEPQFAP
PRPLLGAADS LSQVAPAAPA EPETLPDKYS LQFGFGPFEL PPQWLSETRN SKKRLLPPLG
NTPEELIQTK MPKVGRVERK MSRNNKVSIF PKVDS
//
