ID A0A2I2UQ04_FELCA Unreviewed; 246 AA.
AC A0A2I2UQ04;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=Lymphotoxin-beta {ECO:0000256|ARBA:ARBA00017745};
DE AltName: Full=Tumor necrosis factor C {ECO:0000256|ARBA:ARBA00030168};
DE AltName: Full=Tumor necrosis factor ligand superfamily member 3 {ECO:0000256|ARBA:ARBA00033262};
GN Name=LTB {ECO:0000313|Ensembl:ENSFCAP00000034510.1,
GN ECO:0000313|VGNC:VGNC:68101};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000034510.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000034510.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000034510.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000034510.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000034510.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000034510.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000034510.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the tumor necrosis factor family.
CC {ECO:0000256|ARBA:ARBA00008670}.
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DR EMBL; AANG04003556; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003985965.1; XM_003985916.4.
DR AlphaFoldDB; A0A2I2UQ04; -.
DR PaxDb; 9685-ENSFCAP00000004154; -.
DR Ensembl; ENSFCAT00000048449.3; ENSFCAP00000034510.1; ENSFCAG00000004500.6.
DR GeneID; 101085208; -.
DR KEGG; fca:101085208; -.
DR CTD; 4050; -.
DR VGNC; VGNC:68101; LTB.
DR GeneTree; ENSGT01060000248544; -.
DR OrthoDB; 5319639at2759; -.
DR Proteomes; UP000011712; Chromosome B2.
DR Bgee; ENSFCAG00000004500; Expressed in spleen and 9 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR CDD; cd00184; TNF; 1.
DR Gene3D; 2.60.120.40; -; 1.
DR InterPro; IPR006053; TNF.
DR InterPro; IPR002961; TNF_C.
DR InterPro; IPR021184; TNF_CS.
DR InterPro; IPR006052; TNF_dom.
DR InterPro; IPR008983; Tumour_necrosis_fac-like_dom.
DR PANTHER; PTHR11471:SF29; LYMPHOTOXIN-BETA; 1.
DR PANTHER; PTHR11471; TUMOR NECROSIS FACTOR FAMILY MEMBER; 1.
DR Pfam; PF00229; TNF; 1.
DR PRINTS; PR01234; TNECROSISFCT.
DR PRINTS; PR01237; TNFC.
DR SMART; SM00207; TNF; 1.
DR SUPFAM; SSF49842; TNF-like; 1.
DR PROSITE; PS00251; TNF_1; 1.
DR PROSITE; PS50049; TNF_2; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 19..47
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 91..245
FT /note="TNF family profile"
FT /evidence="ECO:0000259|PROSITE:PS50049"
SQ SEQUENCE 246 AA; 26058 MW; 36D842713D4FE135 CRC64;
MGTLGLEGRG RRPQGKGCLL LAVAGATSLV TLLLAVPITV LAVLALVPQE QGGQVTGTAD
PGAQAQAQQR LGTQVLPEEE AGKDFSSRLP AAHLIGAWTK GQGLGWEAKK EEAFLRSGTQ
FSGAEGLALP QDGLYYLYCH VGYRGRAPPA GGGLLDHSVT LRSRLYRTGG AYGPGTPELL
LEGAETVTPV LDPSRTHEYG PLWYTSVGFG GLVQLRRGER VYVNISHPDM VDYRRGKTFF
GAVMVG
//
