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Database: UniProt
Entry: A0A2I2UQH9_FELCA
LinkDB: A0A2I2UQH9_FELCA
Original site: A0A2I2UQH9_FELCA 
ID   A0A2I2UQH9_FELCA        Unreviewed;       954 AA.
AC   A0A2I2UQH9;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   10-OCT-2018, sequence version 2.
DT   05-JUN-2019, entry version 9.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSFCAP00000034583};
GN   Name=LRP3 {ECO:0000313|Ensembl:ENSFCAP00000034583};
OS   Felis catus (Cat) (Felis silvestris catus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae;
OC   Felinae; Felis.
OX   NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000034583, ECO:0000313|Proteomes:UP000011712};
RN   [1] {ECO:0000313|Ensembl:ENSFCAP00000034583, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000034583,
RC   ECO:0000313|Proteomes:UP000011712};
RX   PubMed=17975172; DOI=10.1101/gr.6380007;
RA   Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA   Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N.,
RA   Schaffer A.A., Agarwala R., Narfstrom K., Murphy W.J., Giger U.,
RA   Roca A.L., Antunes A., Menotti-Raymond M., Yuhki N.,
RA   Pecon-Slattery J., Johnson W.E., Bourque G., Tesler G., O'Brien S.J.;
RT   "Initial sequence and comparative analysis of the cat genome.";
RL   Genome Res. 17:1675-1689(2007).
RN   [2] {ECO:0000313|Ensembl:ENSFCAP00000034583, ECO:0000313|Proteomes:UP000011712}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000034583,
RC   ECO:0000313|Proteomes:UP000011712};
RA   Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT   "Sequence assembly of the Felis catus genome version 6.2.";
RL   Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSFCAP00000034583}
RP   IDENTIFICATION.
RC   STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000034583};
RG   Ensembl;
RL   Submitted (JAN-2018) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR   EMBL; AANG04004361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSFCAT00000038295; ENSFCAP00000034583; ENSFCAG00000014920.
DR   GeneTree; ENSGT00940000160021; -.
DR   Proteomes; UP000011712; Chromosome E2.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   CDD; cd00041; CUB; 2.
DR   CDD; cd00112; LDLa; 4.
DR   Gene3D; 2.60.120.290; -; 2.
DR   Gene3D; 4.10.400.10; -; 4.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR036055; LDL_receptor-like_sf.
DR   InterPro; IPR023415; LDLR_class-A_CS.
DR   InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   Pfam; PF00431; CUB; 1.
DR   Pfam; PF00057; Ldl_recept_a; 3.
DR   PRINTS; PR00261; LDLRECEPTOR.
DR   SMART; SM00042; CUB; 2.
DR   SMART; SM00192; LDLa; 5.
DR   SUPFAM; SSF49854; SSF49854; 2.
DR   SUPFAM; SSF57424; SSF57424; 4.
DR   PROSITE; PS01180; CUB; 2.
DR   PROSITE; PS01209; LDLRA_1; 3.
DR   PROSITE; PS50068; LDLRA_2; 4.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000011712};
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00124,
KW   ECO:0000256|SAAS:SAAS01008102}; Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    787    813       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      333    449       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      544    655       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   REGION       27    302       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2I2UQH9}.
FT   REGION      864    897       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2I2UQH9}.
FT   COMPBIAS    148    166       Polyampholyte. {ECO:0000256|MobiDB-lite:
FT                                A0A2I2UQH9}.
FT   COMPBIAS    245    284       Basic. {ECO:0000256|MobiDB-lite:
FT                                A0A2I2UQH9}.
FT   DISULFID    456    468       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID    463    481       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID    475    490       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID    524    539       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID    727    742       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID    745    757       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID    752    770       {ECO:0000256|PROSITE-ProRule:PRU00124}.
FT   DISULFID    764    779       {ECO:0000256|PROSITE-ProRule:PRU00124}.
SQ   SEQUENCE   954 AA;  101668 MW;  149539A19224EE82 CRC64;
     MFPSISSHAL LCTEGFIVGT CQGQVGYSKR GGRSEGQEQG YLTGQTGLSP APPRAVLPSG
     ALPSPASGPA GSGRDQFVGP KGGPGQSRRG PGSRAGGADW PGRPRGAVQH RGGARAPGPP
     RRLPRPASAT AARRARHVAG AARPPGSERA RGRPRGPTDP RTHQRRHPAA WAGGAGAGWA
     ARRGAWARRG PPGTGRRRRG AGGAGAAAGG GPPWRPPLSP RGARDAAADV APRALRACTA
     ASQRRCRSRS RRPHPAGSRR GSPSRSRSRS RSRSRSRGGR RRRPRAAGPG MEKRATAGPE
     GAPGARAQLA VVCLVNIVLT GRLSSAVPAL AACSGKLEQH TERRGVIYSP AWPLNYPPGT
     NCSWYIQGDR GDMITISFRN FDVEESHQCS LDWLMLGPAA PPRQEAFRLC GSAIPPAFIS
     ARDHVWIFFH SDASSSGQAQ GFRLSYIRGK LGQASCQADE FRCDNGKCLP GPWQCNTVDE
     CGDGSDEGNC SAPASEPPGS LCPGGTFPCS GARSTRCLPA ERRCDGTQDC GDGSDEAGCP
     DLACGRRLGS FYGSFASPDL FGAARGPSDL HCTWLVDTQD PRRVLLQLEL RLGYDDYVQV
     YEGLGERGDR LLQTLSYRSN HRPVSLEAAQ GRLTVAYHAR ARSAGHGFNA TYQVKGYCLP
     WEQPCGSSSE GAAGDAGEQG CFSEPQRCDG WWHCASGRDE QGCPACPPDQ YPCEGGSGLC
     YAPADRCNNQ KSCPDGADEK NCFSCQPGTF HCGTNLCIFE TWRCDGQEDC QDGSDEHGCL
     AAVPRKVITA ALIGSLVCGL LLVIALGCAF KLYSLRTQEY RAFETQMTRL EAEFVRREAP
     PSYGQLIAQG LIPPVEDFPV YSASQNTPRK KTGTPVRMMM TPTPHTMGSE MKLKTSRNAQ
     KTKYAMGTRR FTWGRATGLP TEAQDLPWAL LPHHPGRGGG RGIPRCRPFL GAEA
//
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