ID A0A2I2UVG1_FELCA Unreviewed; 448 AA.
AC A0A2I2UVG1;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Enhancer of zeste 2 polycomb repressive complex 2 subunit {ECO:0000313|Ensembl:ENSFCAP00000036533.3};
GN Name=EZH2 {ECO:0000313|VGNC:VGNC:62018};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000036533.3, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000036533.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000036533.3,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000036533.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000036533.3,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000036533.3}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000036533.3};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04000096; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2UVG1; -.
DR Ensembl; ENSFCAT00000038381.3; ENSFCAP00000036533.3; ENSFCAG00000008618.6.
DR VGNC; VGNC:62018; EZH2.
DR GeneTree; ENSGT00940000155013; -.
DR Proteomes; UP000011712; Chromosome A2.
DR Bgee; ENSFCAG00000008618; Expressed in embryonic head and 10 other cell types or tissues.
DR GO; GO:0042054; F:histone methyltransferase activity; IEA:InterPro.
DR InterPro; IPR045318; EZH1/2-like.
DR InterPro; IPR048358; EZH1/2_MCSS.
DR InterPro; IPR041343; PRC2_HTH_1.
DR InterPro; IPR001005; SANT/Myb.
DR PANTHER; PTHR45747; HISTONE-LYSINE N-METHYLTRANSFERASE E(Z); 1.
DR PANTHER; PTHR45747:SF3; HISTONE-LYSINE N-METHYLTRANSFERASE EZH2; 1.
DR Pfam; PF21358; Ezh2_MCSS; 1.
DR Pfam; PF18118; PRC2_HTH_1; 1.
DR SMART; SM00717; SANT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 160..251
FT /note="Myb-like"
FT /evidence="ECO:0000259|SMART:SM00717"
FT REGION 181..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 341..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 181..196
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 197..221
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 375..407
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 448 AA; 51130 MW; 2D4E81F4B32944E8 CRC64;
METAKDTACP HPDFCELIAR DQGGHSPALP STIFHNTVFT WNQPSAKSLS LVVSSYNYYF
WLDFPLQLPV VQPHSRLLYQ LVDCSVTSDL DFPTQIIPLK TLNAVASVPI MYSWSPLQQN
FMVEDETVLH NIPYMGDEVL DQDGTFIEEL IKNYDGKVHG DRECGFINDE IFVELVNALG
QYNDDDDDDD GDDPDEREEK QKDLEENRDD KESRPPRKFP SDKIFEAISS MFPDKGTAEE
LKEKYKELTE QQLPGALPPE CTPNIDGPNA KSVQREQSLH SFHTLFCRRC FKYDCFLHPF
HATPNTYKRK NTETALDNKP CGPQCYQHLE GAKEFAAALT AERIKTPPKR PGGRRRGRLP
NNSRPSTPTI NVLESKDTDS DREAGTETGG ENNDKEEEEK KRRDFQFLGS EFSMSNANKD
EAKYRASRKR GVEWCRGLDV QGPHWHVL
//
