ID A0A2I2UVW3_FELCA Unreviewed; 450 AA.
AC A0A2I2UVW3;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=Keratin, type I cytoskeletal 27 {ECO:0000256|ARBA:ARBA00040314};
DE AltName: Full=Cytokeratin-27 {ECO:0000256|ARBA:ARBA00041720};
DE AltName: Full=Keratin-27 {ECO:0000256|ARBA:ARBA00042484};
DE AltName: Full=Type I inner root sheath-specific keratin-K25irs3 {ECO:0000256|ARBA:ARBA00043216};
GN Name=KRT25 {ECO:0000313|VGNC:VGNC:108194};
GN Synonyms=KRT27 {ECO:0000313|Ensembl:ENSFCAP00000036683.1};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000036683.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000036683.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000036683.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000036683.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000036683.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000036683.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000036683.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Essential for the proper assembly of type I and type II
CC keratin protein complexes and formation of keratin intermediate
CC filaments in the inner root sheath (irs).
CC {ECO:0000256|ARBA:ARBA00037136}.
CC -!- SUBUNIT: Heterotetramer of two type I and two type II keratins.
CC Interacts with KRT6A to form filaments.
CC {ECO:0000256|ARBA:ARBA00038833}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; AANG04003358; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003996887.1; XM_003996838.3.
DR AlphaFoldDB; A0A2I2UVW3; -.
DR Ensembl; ENSFCAT00000033386.3; ENSFCAP00000036683.1; ENSFCAG00000042427.2.
DR GeneID; 111556209; -.
DR KEGG; fca:111556209; -.
DR CTD; 342574; -.
DR VGNC; VGNC:108194; KRT25.
DR GeneTree; ENSGT00940000161994; -.
DR InParanoid; A0A2I2UVW3; -.
DR OMA; SRVHTME; -.
DR OrthoDB; 4640531at2759; -.
DR Proteomes; UP000011712; Chromosome E1.
DR Bgee; ENSFCAG00000042427; Expressed in tip of external ear and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0030855; P:epithelial cell differentiation; IBA:GO_Central.
DR GO; GO:0031069; P:hair follicle morphogenesis; IBA:GO_Central.
DR GO; GO:0045109; P:intermediate filament organization; IBA:GO_Central.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR23239; INTERMEDIATE FILAMENT; 1.
DR PANTHER; PTHR23239:SF120; KERATIN, TYPE I CYTOSKELETAL 27; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 2.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 74..389
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 425..450
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 78..112
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 188..222
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 247..353
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 425..441
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 450 AA; 49195 MW; BF65A34AA076301D CRC64;
MSVRFSSASR RLGSSGGVGF GAGNACGVPG IGSGFSCAFG GSSPAGGYGG GLGAGTASCT
AFMGNEHGLL SGNEKVTMQN LNDRLASYLE NVRALEEANA DLEQKIKGWY EKFGPGSCRG
LDHDYSRYFP IIDDLRNQII SVTTSNANII LQNDNARLTA DDFRLKFENE QALHQSVDAD
VSGLRRVLDE LTLCRTDLEI QLETLSEELA YLKKNHEEEM KALQCAAGGN VNVEMNAAPG
VDLTVLLNNM RAEYEDLAEQ NRRDAEAWFN EKSASLQQQI SDDAGATTSA RNELTEMKRT
LQTLEIELQS LLAMKHSLEC SLTETEGNYC TQLAQIQAQI GALEEQLHQV RTETEGQKLE
YEQLLDIKVH LEKEIETYCR LIDGEDGSCV KSKGYGGPGN QTKDSSKTTM VKTIVEEIDP
RGKVLSSRVH TVEEKSTKAN NIKSEQRVPS
//
