ID A0A2I2UWQ4_FELCA Unreviewed; 567 AA.
AC A0A2I2UWQ4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Cell division cycle 45 {ECO:0000313|Ensembl:ENSFCAP00000036937.1};
GN Name=CDC45 {ECO:0000313|Ensembl:ENSFCAP00000036937.1,
GN ECO:0000313|VGNC:VGNC:60662};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000036937.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000036937.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000036937.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000036937.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000036937.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000036937.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000036937.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the CDC45 family.
CC {ECO:0000256|ARBA:ARBA00010727}.
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DR EMBL; AANG04000826; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_003994981.1; XM_003994932.3.
DR AlphaFoldDB; A0A2I2UWQ4; -.
DR STRING; 9685.ENSFCAP00000036937; -.
DR PaxDb; 9685-ENSFCAP00000003964; -.
DR Ensembl; ENSFCAT00000037885.3; ENSFCAP00000036937.1; ENSFCAG00000004297.6.
DR GeneID; 101097519; -.
DR KEGG; fca:101097519; -.
DR CTD; 8318; -.
DR VGNC; VGNC:60662; CDC45.
DR GeneTree; ENSGT00390000009662; -.
DR InParanoid; A0A2I2UWQ4; -.
DR OMA; MYLPRQL; -.
DR OrthoDB; 1407079at2759; -.
DR Proteomes; UP000011712; Chromosome D3.
DR Bgee; ENSFCAG00000004297; Expressed in testis and 9 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR GO; GO:0071162; C:CMG complex; IEA:Ensembl.
DR GO; GO:0031261; C:DNA replication preinitiation complex; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0003688; F:DNA replication origin binding; IBA:GO_Central.
DR GO; GO:0003697; F:single-stranded DNA binding; IBA:GO_Central.
DR GO; GO:0006270; P:DNA replication initiation; IBA:GO_Central.
DR GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:Ensembl.
DR GO; GO:0000727; P:double-strand break repair via break-induced replication; IBA:GO_Central.
DR GO; GO:1902977; P:mitotic DNA replication preinitiation complex assembly; IBA:GO_Central.
DR InterPro; IPR003874; CDC45.
DR PANTHER; PTHR10507; CDC45-RELATED PROTEIN; 1.
DR PANTHER; PTHR10507:SF0; CELL DIVISION CONTROL PROTEIN 45 HOMOLOG; 1.
DR Pfam; PF02724; CDC45; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT REGION 138..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 139..159
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 567 AA; 65338 MW; BCBCF0FB0E381E4E CRC64;
MFVSDFRKEF YEVVQNQRVL LFVASDVDAL CACKILQALF QCDHVQYTLV PVSGWQELET
AFLEHKEQFH YFILINCGAN VDLLDILQPD EDAIFFVCDT HRPVNVVNVY NDTQIKLLIK
QDDDLEVPAY DDIFRDEEEG EEHSGNESDN GSEPSVKRTR LEEEIVAQTM KRRQRREWEA
RRRDILFDYE QYEYHGTSSA MVMFDLAWMM SKDLNDMLWW AIVGLTDQWV QDKITQMKYV
TDVGILQRHV SRHNHRNEDE ENSLSVDCTR ISFEYDLRLA LYQHWSLHDS LCNTCYTAAR
FKLWSVHGQK RLQEFLADVG LPLKQVKQKF QSMDVSLKEN LREMIEESAN KFGMKDMRVQ
TFSIHFGFKH KFLASDVVFA TMSLMESPEK DGSGTDNFIQ ALDSLSRSNL DKLYHGLELA
KKQLRATQQT IASCLCTNLV ISQGPFLYCS LMEGTPDIVL FSKPASLSLL SRHLLKSFVC
STKNRRCKLL PLVMAAPLSV EQGTVTVVGI PPETDSSDRK NFFGRAFEKA AEGTNSRTLH
NHFDLSVIEL KAEDRSKFLD ALVSLLS
//
