ID A0A2I2UX05_FELCA Unreviewed; 1665 AA.
AC A0A2I2UX05;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Kinesin family member 1B {ECO:0000313|Ensembl:ENSFCAP00000037032.2};
GN Name=KIF1B {ECO:0000313|Ensembl:ENSFCAP00000037032.2,
GN ECO:0000313|VGNC:VGNC:63110};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000037032.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000037032.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000037032.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000037032.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000037032.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000037032.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000037032.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, axon
CC {ECO:0000256|ARBA:ARBA00004489}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AANG04003082; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSFCAT00000043325.3; ENSFCAP00000037032.2; ENSFCAG00000014588.6.
DR VGNC; VGNC:63110; KIF1B.
DR GeneTree; ENSGT00940000157445; -.
DR Proteomes; UP000011712; Chromosome C1.
DR Bgee; ENSFCAG00000014588; Expressed in prefrontal cortex and 9 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0003777; F:microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR CDD; cd22727; FHA_KIF1B; 1.
DR CDD; cd01365; KISc_KIF1A_KIF1B; 1.
DR CDD; cd01233; PH_KIFIA_KIFIB; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 6.10.250.2520; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR022164; Kinesin-like.
DR InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR InterPro; IPR032405; Kinesin_assoc.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR049780; PH_KIFIA_KIFIB.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR InterPro; IPR031852; Vik1/Cik1_MT-bd.
DR PANTHER; PTHR47117:SF2; KINESIN-LIKE PROTEIN KIF1A ISOFORM X1; 1.
DR PANTHER; PTHR47117; STAR-RELATED LIPID TRANSFER PROTEIN 9; 1.
DR Pfam; PF12473; DUF3694; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF12423; KIF1B; 1.
DR Pfam; PF00225; Kinesin; 1.
DR Pfam; PF16183; Kinesin_assoc; 1.
DR Pfam; PF16796; Microtub_bd; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00129; KISc; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 5..326
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT DOMAIN 488..544
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 1550..1648
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1399..1420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1469..1509
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 607..663
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1399..1419
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 97..104
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1665 AA; 187455 MW; C6DE64F37E03A52C CRC64;
MSGASVKVAV RVRPFNSRET SKESKCIIQM QGNSTSIINP KNPKEAPKSF SFDYSYWSHT
SPEDPCFASQ NRVYNDIGKE MLLHAFEGYN VCIFAYGQTG AGKSYTMMGK QEESQAGIIP
QVSYMEIYCE RVRDLLNPKN KGHLRVREHP LLGPYVEDLS KLAVTSYTDI ADLMDAGNKA
RTVAATNMNE TSSRSHAVFT IVFTQKKHDT ETNLSTEKVS KISLVDLAGS ERADSTGAKG
TRLKEGANIN KSLTTLGKVI SALAEVSKKK KKTDFIPYRD SVLTWLLREN LGGNSRTAMV
AALSPADINY DETLSTLRYA DRAKQIKCNA VINEDPNAKL VRELKEEVTR LKDLLRAQGL
GDIIDTSMGS LTSSPSSCSL SSQVGLTSVT SIQERIMSTP GGEEAIERLK ESEKIIAELN
ETWEEKLRKT EAIRMEREAL LAEMGVAIRE DGGTLGVFSP KKTPHLVNLN EDPLMSECLL
YYIKDGITRV GQADAERRQD IVLSGAHIKE EHCIFRSERN NSGDVIVTLE PCERSETYVN
GKRVAQPVQL RSGNRIIMGK NHVFRFNHPE QARAEREKTP SAETPSEPVD WTFAQRELLE
KQGIDMKQEM EKRLQEMEIL YKKEKEEADL LLEQQRLDYE SKLQALQKQV ETRSLAAETT
EEEEEEEEVP WTQHEFELAQ WAFRKWKSHQ FTSLRDLLWG NAVYLKEANA ISVELKKKVQ
FQFVLLTDTL YSPLPPELLP TEVEKTHDDR PFPRTVVAVE VQDLKNGATH YWSLEKLKQR
LDLMREMYDR AGEVASGAQD ESEATVTGSD PFYDRFHWFK LVGRAFVYLS NLLYPVPLIH
RVAIVSEKGE VRGFLRVAVQ AIAADEEAPD YGSGIRQSGT AKISFDNEYF NQNDFSSVAM
TRSGLSLEEL RIVEGQGQSS EVITPPEEIN RMNDLDLKSS TLLDGKMVME GFSEEIGNHL
KLGSAFTFRV TVLQASGILP EYADIFCQFN FLHRHDEAFS TEPLKNNGRG SPLGFYHVQN
IAVEVTESFV DYIKTKPIVF EVFGHYQQHP LHLQGQDLNS PPQPSRRFFP PPMPLSKPVP
ATKLNTMSKT SLGQSMSKYD LLVWFEISEL EPTGEYIPAV VDHTAGLPCQ GTFLLHQGIQ
RRITVTIIHE KGSELHWKDV RELVVGRIRN KAEVDEAAVD AILSLNIISA KYLKSSHNSS
RTFYRFEAVW DSSLHNSLLL NRVTPYGEKI YMTLSAYLEL DHCIQPAVIT KDVCMVFYSR
DAKISPPRSL RSLFGSGYSK SPDSNRVTGI YELSLCKMAD TGSPGMQRRR RKILDTSVAY
VRGEENLAGW RPRGDSLILE HQWELEKLEL LHEVEKTRHF LLLRERLGDS IPKSLSDSLS
PSLSSGTLST STSISSQIST TTFESAITPS ESSGYDSTDI ESLVDREKEL ATKCLQLLTH
TFNREFSQLH GSISDCKLSD ISPIGRDPSV SSFSSATLTP SSTCPSLVEA RSNSQEQKTP
EANSRASSPC PEFEQFQIVP TVETPYLARA GKNEFLNLVP DIEEIRPGSV VSKKGYLHFK
EPLYSNWAKH FVVVRRPYVF IYNSDKDPVE RGIINLSTAQ VEYSEDQQAM VKTPNIFAVC
TKHRGVLLQA LNDKDMNDWL YAFNPLLAGT IRSKLSRRCP SEPKY
//
