ID A0A2I2UYE3_FELCA Unreviewed; 668 AA.
AC A0A2I2UYE3;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Synapse defective Rho GTPase homolog 1 {ECO:0000313|Ensembl:ENSFCAP00000037442.3};
GN Name=SYDE1 {ECO:0000313|VGNC:VGNC:80729};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000037442.3, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000037442.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000037442.3,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000037442.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000037442.3,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000037442.3}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000037442.3};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04002574; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2UYE3; -.
DR STRING; 9685.ENSFCAP00000037442; -.
DR Ensembl; ENSFCAT00000037927.3; ENSFCAP00000037442.3; ENSFCAG00000037273.3.
DR VGNC; VGNC:80729; SYDE1.
DR GeneTree; ENSGT01030000234635; -.
DR InParanoid; A0A2I2UYE3; -.
DR OMA; FLQLDHT; -.
DR Proteomes; UP000011712; Chromosome A2.
DR Bgee; ENSFCAG00000037273; Expressed in eyeball of camera-type eye and 10 other cell types or tissues.
DR GO; GO:0097060; C:synaptic membrane; IBA:GO_Central.
DR GO; GO:0005096; F:GTPase activator activity; IBA:GO_Central.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0016477; P:cell migration; IBA:GO_Central.
DR GO; GO:1901165; P:positive regulation of trophoblast cell migration; IEA:Ensembl.
DR GO; GO:0051493; P:regulation of cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0046578; P:regulation of Ras protein signal transduction; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR46150; RHO GTPASE-ACTIVATING PROTEIN 100F; 1.
DR PANTHER; PTHR46150:SF2; RHO GTPASE-ACTIVATING PROTEIN SYDE1; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011712}.
FT DOMAIN 331..537
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 533..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 611..634
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 9..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..144
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..199
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 535..549
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..632
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 668 AA; 72527 MW; 0D648501687A6F0D CRC64;
MAEPLLRKTF SRLRGREKLP RKKSDAKERG RPAQRPEPSP PEPEPHAPEK SQAGAEGPPS
PEASRSPARG AYLQSLEPSS RRWVLGGAKP PEEAALGPRA PGSGEPAGEI WYNPIPEEDS
RPLAPEPPGP QPGSAEPEGP PSPEASRSPV LQSQSPTPPK SPRLGQRAPL APRHPGGPPS
PEASRSIPEP SPPEPEPHAP EKSQAGAEGP PSPEASRSPA RGACLLQVDG VARARTGPLR
GGPDFLRLDH TFHLELEAAR LLRALVLAWD PGVRRHRPCA QGTVLLPTVF RGCQAQQLAV
RLEPQGLLYA KLTLSEQQEA PGTAEPRVFG LPLPLLVERE QPPGQVPLII QKCVGQIERR
GLRVVGLYRL CGSAAVKKEL RDAFERDSAA VCLSEDLYPD INVITGILKD YLRELPTPLI
TQPLYQVVLE AMARGPPSRA PSSTEGTRGL LNCLPDVERA TLTLLLDHLR LVSSFHAHNR
MTPQNLAVCF GPVLLPARQS PARPRIRSSG PGPTNAVDFK RHIEVLHYLL QAWPDPRRPP
EPPDVAPYVR PKRQPSLHLP LASPEVVTRP RGRGGPESPP SNRYAGDWSV CGRDFLPCGR
DFLSGPDYEH VTGSCSEDED EDAGEPAGAA DFDDDFEAPF NPHLNLKDFD ALILDLEREL
SKQINVCL
//
