ID A0A2I2V0B5_FELCA Unreviewed; 688 AA.
AC A0A2I2V0B5;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 2.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Growth hormone receptor {ECO:0000256|ARBA:ARBA00017448};
DE AltName: Full=Somatotropin receptor {ECO:0000256|ARBA:ARBA00031294};
GN Name=GHR {ECO:0000313|Ensembl:ENSFCAP00000038200.2,
GN ECO:0000313|VGNC:VGNC:62544};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000038200.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000038200.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000038200.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000038200.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000038200.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000038200.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000038200.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: The soluble form (GHBP) acts as a reservoir of growth hormone
CC in plasma and may be a modulator/inhibitor of GH signaling.
CC {ECO:0000256|ARBA:ARBA00003894}.
CC -!- SUBUNIT: On growth hormone (GH) binding, forms homodimers and binds
CC JAK2 via a box 1-containing domain. Binding to SOCS3 inhibits JAK2
CC activation, binding to CIS and SOCS2 inhibits STAT5 activation.
CC {ECO:0000256|ARBA:ARBA00011703}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 1
CC subfamily. {ECO:0000256|ARBA:ARBA00007885}.
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DR EMBL; AANG04003171; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2V0B5; -.
DR STRING; 9685.ENSFCAP00000038200; -.
DR PaxDb; 9685-ENSFCAP00000023826; -.
DR Ensembl; ENSFCAT00000042121.2; ENSFCAP00000038200.2; ENSFCAG00000026499.4.
DR VGNC; VGNC:62544; GHR.
DR GeneTree; ENSGT00940000159987; -.
DR InParanoid; A0A2I2V0B5; -.
DR OMA; YKPQLYN; -.
DR Proteomes; UP000011712; Chromosome A1.
DR Bgee; ENSFCAG00000026499; Expressed in liver and 11 other cell types or tissues.
DR GO; GO:0036464; C:cytoplasmic ribonucleoprotein granule; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0070195; C:growth hormone receptor complex; IBA:GO_Central.
DR GO; GO:0019955; F:cytokine binding; IBA:GO_Central.
DR GO; GO:0019838; F:growth factor binding; IBA:GO_Central.
DR GO; GO:0004903; F:growth hormone receptor activity; IBA:GO_Central.
DR GO; GO:0017046; F:peptide hormone binding; IBA:GO_Central.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IBA:GO_Central.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0060396; P:growth hormone receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0042445; P:hormone metabolic process; IEA:Ensembl.
DR GO; GO:0048009; P:insulin-like growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0040018; P:positive regulation of multicellular organism growth; IEA:Ensembl.
DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IBA:GO_Central.
DR GO; GO:0046427; P:positive regulation of receptor signaling pathway via JAK-STAT; IBA:GO_Central.
DR CDD; cd00063; FN3; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR025871; GHBP.
DR InterPro; IPR015152; Growth/epo_recpt_lig-bind.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003528; Long_hematopoietin_rcpt_CS.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF108; GROWTH HORMONE RECEPTOR; 1.
DR Pfam; PF09067; EpoR_lig-bind; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF12772; GHBP; 1.
DR SMART; SM00060; FN3; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS01352; HEMATOPO_REC_L_F1; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 201..304
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 478..501
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 478..500
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 688 AA; 77045 MW; 685E1A627954B3F8 CRC64;
MDFRWSWKDV FSPRDPWKTS FEFKHHPSLI SFHTCKLLIH ISLRKVDPTG MDLWQLLLTL
AVAGSSSAFS GSEATPAILG RASQSLQRVN PGLGTNSSGK PKFTKCRSPE LETFSCHWTD
GVRRGFKSPG STQLFYIRRS TQEWTQEWKE CPDYVSAGEN SCYFNSSYTS IWIPYCIKLT
SNGGTVDQKC FSVEEIVQPD PPIGLNWTLL NISLTGIHAD IQVRWEPPPN ADVQKGWIVL
EYELQYKEVN ESQWKTMDPV LSTSVPVYSL RLDKEYEVRV RSRQRNSEKY GEFSEVLYVT
LPQMSPFACE EDFQFPWFLI TIFGIFGLTM ILFLFIFSKQ QRIKMLILPP VPVPKIKGID
PDLLKEGKLE EVNTILAIHD NYKPEFYNDD SWVEFIELDI DDPDEKTEGS DTDRLLSNDH
EKSLNILGAK DDDSGRTSCY EPDILETDFN ASDMCDGTSE VAQPQRLKGE VDLLCLDQKN
QNNSPSTDAT PTTQQPSVIL AKENKPRPLL TSGTESTHQA AHTQLSNPSS LANIDFYAQV
SDITPAGSVV LSPGQKNKAG ISPCDMHPEA VSLCQANFIM DNAYFCEADA KKCIAVAPHV
EAESRVEPNF NQEDIYITTE SLTTTAGQSG TAERAPGSEM PVPDYTSIHI VQSPQGLVLN
ATALPLPDKE FLSSCGYVST DQLNKIMP
//
