ID A0A2I2V0B7_FELCA Unreviewed; 1439 AA.
AC A0A2I2V0B7;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 10-OCT-2018, sequence version 2.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=phosphoinositide 5-phosphatase {ECO:0000256|ARBA:ARBA00013044};
DE EC=3.1.3.36 {ECO:0000256|ARBA:ARBA00013044};
GN Name=SYNJ2 {ECO:0000313|Ensembl:ENSFCAP00000038098.2,
GN ECO:0000313|VGNC:VGNC:65887};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000038098.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000038098.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000038098.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000038098.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000038098.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000038098.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000038098.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-
CC bisphosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
CC inositol 4-phosphate) + phosphate; Xref=Rhea:RHEA:22764,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:58178,
CC ChEBI:CHEBI:58456; EC=3.1.3.36;
CC Evidence={ECO:0000256|ARBA:ARBA00001786};
CC -!- SIMILARITY: Belongs to the synaptojanin family.
CC {ECO:0000256|ARBA:ARBA00008943}.
CC -!- SIMILARITY: In the central section; belongs to the inositol 1,4,5-
CC trisphosphate 5-phosphatase family. {ECO:0000256|ARBA:ARBA00009678}.
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DR EMBL; AANG04000169; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSFCAT00000041813.3; ENSFCAP00000038098.2; ENSFCAG00000010854.6.
DR VGNC; VGNC:65887; SYNJ2.
DR GeneTree; ENSGT00940000160715; -.
DR Proteomes; UP000011712; Chromosome B2.
DR Bgee; ENSFCAG00000010854; Expressed in prefrontal cortex and 9 other cell types or tissues.
DR GO; GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro.
DR CDD; cd12720; RRM_SYNJ2; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR046985; IP5.
DR InterPro; IPR000300; IPPc.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR002013; SAC_dom.
DR InterPro; IPR015047; SYNJ1/2_RRM.
DR InterPro; IPR034973; SYNJ2_RRM.
DR PANTHER; PTHR11200; INOSITOL 5-PHOSPHATASE; 1.
DR PANTHER; PTHR11200:SF148; SYNAPTOJANIN-2; 1.
DR Pfam; PF08952; DUF1866; 1.
DR Pfam; PF02383; Syja_N; 1.
DR SMART; SM01165; DUF1866; 1.
DR SMART; SM00128; IPPc; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
DR PROSITE; PS50275; SAC; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT DOMAIN 120..444
FT /note="SAC"
FT /evidence="ECO:0000259|PROSITE:PS50275"
FT DOMAIN 889..968
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 1156..1288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1304..1346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1167..1181
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1198..1213
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1220..1234
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1256..1279
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1439 AA; 158809 MW; 0228C8984BB00863 CRC64;
MALSKGLRLL GRLDPAGESS VLLEARGRGD CLLFEAGTVA TLAPEEKEVI KGQYGKITDA
YGCLGELRLK SGGASLSFLV LVTGCTSVGR IPEAEIYKIT ATDFYPLQEE AKEEDRLTAL
RKILNSGFFY FSWPNDGSSF DLTVRAQKQD HDSYEWGSSF FWNQLLHVPL RQHQVSCCDW
LLKVICGVVS IRTVYASHKQ AKACLISRIS CERAGARFHT RGVNDDGHVS NFVETEQTIY
MDDGVSSFVQ IRGSVPLFWE QPGLQVGSHH LRLNRGLEAN APAFDRHMVL LKEQYGKQVV
VNLLGSRGGE EVLNRAFKKL LWASCHAGDT PMINFDFHQL AKGGKLEKLE NLLRPQLKLH
WDDFGVFTKG ENVSPRFQKG TLRMNCLDCL DRTNTVQSFI ALEVLHLQLE SLGLNSKPIA
DRFVESFKAM WSLNGHSLSK MFTGSRALEG KAKVGKLKDG ARSVSRTIQS NFFDGVKQEA
IKLLLVGDVY TEESADRGRV LLDNTALLVT PRILRAMAER QSEFTHFRRI RIAMGTWNVN
GGKQFRSNLL GTAELADWLL DSPKLSGLAG SPDDDSPADI FAVGFEEMVE LSAGNIVNAS
TTNRKMWGEQ LQKAISRSHR YILLTSAQLV GVCLYIFVRP YHVPFIRDVA IDTVKTGMGG
KAGNKGAVGI RFQFHSTSLC FVCSHLTAGQ AQVKERNDDY REITQKLSFP MGRNIFSHDY
VFWCGDFNYR IDLTYEEVFY FVKRQDWKKL LEFDQLQLQK SSGKIFKDFH EGTINFGPTY
KYDVGSAAYD TSDKCRTPAW TDRVLWWRKR HPFDRTAGDL NLLDNDIDAD STVRHSWSPG
ALKYYGRAEL QASDHRPVLA IVEVEVQEVD VGARERVFQE VSSFQGPLDA TVIVNLQSPT
VEEKNEFPED VRTELMQTLG NYGTIVLVRV NQGQMLVTFA DSHSALSVLD VDGMKVKGRA
VKIRPKTKDW LKGWQEEIIR KRDSMASMSP TANSCLLEEN FDFTSLDYES EGDILEDDED
YLVDELSQPV VSDGETAGDY LSEAPSCTAA VPADTSPALT KKTRHPTYKA GLMVKKSASD
VSISSGTHGQ YSILQTAKLL PGAPQHAPKA RTGISKPYNV KQIKTTNAQE AEAAIRCLLE
ARGGIPGEAV NATALRNQGT SKPEPPVAVA PLLPRRPAPR VPAIKKPTLR RTGKPESPEE
QCGQQSVHFT IGPPETSLET PPLAAVPPVP KPRTLQPRKG TDRKASGGKP VPNDAPPAAG
ATPPPPLEVL PPAPQAPPRR KKSAPAAFHL QVLQSNSQLL QSLTCSSSDC PPAPRPDQGV
LFPQPAHPGP LSAAGAQADG TKETQPEAAS LLGDYQDPFW NLLHDTHLLK NAWLSKNSDP
LDPGTGSLER AHTASLQISA SVADNLPPEH GPNDLGHWMT ISDKDKRTVL QVFDPLAET
//
