ID A0A2I2V0M9_FELCA Unreviewed; 1463 AA.
AC A0A2I2V0M9;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=LIM domain 7 {ECO:0000313|Ensembl:ENSFCAP00000038132.2};
GN Name=LMO7 {ECO:0000313|Ensembl:ENSFCAP00000038132.2,
GN ECO:0000313|VGNC:VGNC:68073};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000038132.2, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000038132.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000038132.2,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000038132.2, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000038132.2,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000038132.2}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000038132.2};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR EMBL; AANG04001781; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSFCAT00000039521.3; ENSFCAP00000038132.2; ENSFCAG00000008534.6.
DR VGNC; VGNC:68073; LMO7.
DR GeneTree; ENSGT00950000183159; -.
DR Proteomes; UP000011712; Chromosome A1.
DR Bgee; ENSFCAG00000008534; Expressed in zone of skin and 11 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0030155; P:regulation of cell adhesion; IEA:InterPro.
DR GO; GO:0023051; P:regulation of signaling; IEA:InterPro.
DR CDD; cd08368; LIM; 1.
DR CDD; cd00136; PDZ; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 1.
DR InterPro; IPR031865; DUF4757.
DR InterPro; IPR029978; LMO-7.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR46767; LIM DOMAIN ONLY PROTEIN 7; 1.
DR PANTHER; PTHR46767:SF1; LIM DOMAIN ONLY PROTEIN 7; 1.
DR Pfam; PF15949; DUF4757; 2.
DR Pfam; PF00412; LIM; 1.
DR Pfam; PF00595; PDZ; 1.
DR SMART; SM00132; LIM; 1.
DR SMART; SM00228; PDZ; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 1.
DR PROSITE; PS50106; PDZ; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00125};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 825..908
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1392..1458
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT REGION 26..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 165..185
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 531..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 733..821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 967..1018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1090..1262
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1292..1384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1018..1068
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 165..180
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 531..571
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 583..600
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 642..687
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 733..754
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 769..796
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..821
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1097..1177
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1184..1212
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1213..1241
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1242..1262
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1299..1384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1463 AA; 166775 MW; 760C923416461740 CRC64;
MQDYNKDDMS YRRISAIEPK SALPFNRFLP NKSRQPSYVP APLRKKKPDK YEDNRRSWAS
PVYAEADGTF PSNERRTWGT NVENWPTIQE TSNSSCYLEE KEAKTSTPNT VKDDLYVRKL
SPIMPNPGHA FDQFLPKCWI PEDVNWKRIK RETYKPWYKE FQGFSRRNSD SEDEDSGSHR
SSSIFSRIQK AKHRLDSNCQ RRSLLLELAT RGAKNSWDTH AARGASGAAD EPSQFLLLQA
LQTYSDDILS SETNTKIDPT AGPRLITRRK NLFSAPGYKR DDLEMSTLDP DLENDDFFVR
KTGAFHANPY VLRAFEDLRR FSEQDDPVER DIILQCREGE LVLPDLEKDD MVVRRLPAQK
KEVPLSGAPD RYQPVPFPEP WTLPPEIQAK FLCVLERTHP SKEKRKSCRV LVPSYRQKKD
DLLTRKIQSW QLGTTVPPVS FIPGPCSEAD LQRWEAIREA SRLRHKKRLM VERLFQKIYG
ENGSKSMSDV SADDVQNLRQ LRYEEMQKIK SQLKEQDQKW QDDLAKWKDR RKSYTSDLQK
KKEEREEIEK QALEKSERGS KTFKEMLQDR ESRNQTSAVV SRRRLHSSDD ILHEEKLSPR
LTTSEASYQS ERVEEKETTY SAEVPKQDST TFAKREDAAA AEIQLSSQSP MEEQHPDALS
SQHSPSTQTE STRISASLPR SYQKTDTARL TSVVTPRPFG SQARGISSLP RSYTMDDGWK
YNGDVEYVKR TQSSLVSTSV HKPDTSQLAT SKSSEREGVA VGEGVMQLPS PTPSFSSLSQ
EEAATSKATL SSPSGPDLMS ELGEGGSSPQ TEVSRSSQDQ FSDMRISIHQ TPGSGLDFGF
TVKWVFSGIF VASIEAGSPA EFSQLQVDDE IIAVNNTKFS YKDTKEWEAT MANAQETGNL
VMDIRRYGKS DWGRDQPSLP FTRHKTLNLT SMATKIIGSP ETKWIDTTSG IYNSDKSSNL
SVTTDFSESL QHSNTESKEI NGIRDESNTF ESKGSSDSVV PDLPVPTLSA PSRWAWDQEE
ERKRQERWQK EQDRLLQEKY QREQEKLREE WQRAKQEAER ENYKYLNEEL MVLNSNSISL
TAREPAVASW EATWGEGSKS SDREGTRAGE EERSQQQKEG ADEDQRKKLQ EQLTLEKERT
PEEPQYQEGQ EQKRHPAEAE ERKHQAERER ETSVRIYQYR RPIDSYDLPK REEKSPGLLP
SDRNKSRSTT ELDDYPTNKN GSSKYLDRIG STSSSQRSSK KEQVPSEAEL ERQQILQEMR
KRTSLHNDNS WIRQRSSSVN KEPICLPGIM RRGESLDNLD SPRSNSWKPS PWLNQSSGVH
ASSSVQDFSR PPPQLVSTSN RAYMRNPSSS VPPPSTGSVK TTTAPSPTPR SHSPSASQLG
SQLRNRSVSG KRMCSYCNNI LGKGAAMIIE SLGLCYHLHC FKCIACERDL GGSSSGAEVR
IRNHQLYCND CYLRYKSGRP TAM
//
