ID A0A2I2V3U6_FELCA Unreviewed; 2111 AA.
AC A0A2I2V3U6;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Dysferlin {ECO:0000313|Ensembl:ENSFCAP00000039260.3};
GN Name=DYSF {ECO:0000313|Ensembl:ENSFCAP00000039260.3,
GN ECO:0000313|VGNC:VGNC:61689};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000039260.3, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000039260.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000039260.3,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000039260.3, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000039260.3,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000039260.3}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000039260.3};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004483}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004483}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the ferlin family.
CC {ECO:0000256|ARBA:ARBA00007561}.
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DR EMBL; AANG04002548; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PaxDb; 9685-ENSFCAP00000004023; -.
DR Ensembl; ENSFCAT00000037555.3; ENSFCAP00000039260.3; ENSFCAG00000004357.6.
DR VGNC; VGNC:61689; DYSF.
DR GeneTree; ENSGT00940000156187; -.
DR Proteomes; UP000011712; Chromosome A3.
DR Bgee; ENSFCAG00000004357; Expressed in adult mammalian kidney and 10 other cell types or tissues.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd08373; C2A_Ferlin; 1.
DR CDD; cd04011; C2B_Ferlin; 1.
DR CDD; cd04018; C2C_Ferlin; 1.
DR CDD; cd04017; C2D_Ferlin; 1.
DR CDD; cd04037; C2E_Ferlin; 1.
DR CDD; cd08374; C2F_Ferlin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 6.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037726; C2A_Ferlin.
DR InterPro; IPR037720; C2B_Ferlin.
DR InterPro; IPR037722; C2C_Ferlin.
DR InterPro; IPR037723; C2D_Ferlin.
DR InterPro; IPR037724; C2E_Ferlin.
DR InterPro; IPR037725; C2F_Ferlin.
DR InterPro; IPR012968; FerIin_dom.
DR InterPro; IPR037721; Ferlin.
DR InterPro; IPR012560; Ferlin_A-domain.
DR InterPro; IPR012561; Ferlin_B-domain.
DR InterPro; IPR032362; Ferlin_C.
DR InterPro; IPR006614; Peroxin/Ferlin.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR PANTHER; PTHR12546:SF33; SPERM VESICLE FUSION PROTEIN FER-1; 1.
DR Pfam; PF00168; C2; 7.
DR Pfam; PF08165; FerA; 1.
DR Pfam; PF08150; FerB; 1.
DR Pfam; PF08151; FerI; 1.
DR Pfam; PF16165; Ferlin_C; 1.
DR SMART; SM00239; C2; 7.
DR SMART; SM00694; DysFC; 2.
DR SMART; SM00693; DysFN; 2.
DR SMART; SM01200; FerA; 1.
DR SMART; SM01201; FerB; 1.
DR SMART; SM01202; FerI; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 7.
DR PROSITE; PS50004; C2; 7.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 2077..2098
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..101
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 236..354
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 393..520
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1146..1272
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1320..1448
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1592..1710
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1826..1974
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 134..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 177..248
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2026..2048
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..229
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2111 AA; 239948 MW; B6C52C7BC514E990 CRC64;
MLRVFILYAE NVHTPDTDIS DAYCSAVFAG VKKRTKVIKN SVNPVWNEGF EWDLKGIPLD
QSSELHVVVK DHETMGRNRF LGEANIPLRE VLATPSLSAS FNAPLLDTKK QPTGASLVLQ
VSYTPLPGAV PLFPPSASLE PSPTLPDLDM LAGGGQSRAE TWSLLSDSTV DTRYSGKKWL
APTDTGGEED TEDQGLTGDE AEPLVDQSGA PGPGAPATPR KPPSHPPPYH PGIKRKRSAP
TSRKLLSDKP QDFQIRVQVI EGRQLPGVNI KPVVKVTAAG QTKRTRIQKG NSPLFNETLF
FNVFDSPSEL FDEPIFITVV DSRSLRTDAL IGEFRMDVGT IYREPRHAYL RKWLLLSDPD
DFSAGARGYL KASLCVLGPG DEAPLERKDP SEDKEDIENN LLRPTGVALR GAHFCLKVDD
AVMDNVKQIF GFDSNKKNLV DPFMEVSFAG KMLCSKILEK TANPQWNQSI TLPAMFPSMC
EKMRIRVIDW DRLTHNDIVA TTYLSMSKIS APGGEIEVDD HLGFLPTFGP CYVNLYGSPR
EFTGFPDPYA ELNMGKGEGV AYRGRVLLSL ETKLVEHSEQ KVEDLPADDI LRVEKYLRRR
KYSLFAAFYS ASMLQDVDDA IQFEVSIGNY GNKFDTTCLP LASTTQYSRA VFDGCHYYYL
PWGNVKPVVV LSSYWEDISH RVEAQNQLLR IADRLEAGLE QVHLALKAQC SPEDVDSLLA
QLMDELISDC SQPLGDVQEI PSATHLDQYL YKLRTRHLGQ ITEAALALKL GRSELPAALE
QAEDWLLRVR ALADEPQNSL PDIIIWMLQG DKRVAYQRVP AHEILFSRRG PNYCGKNCGK
LQTIFLKYPM EGVPGARMPV QIRVKLWFGL SVDEKEFNQF AEGKLSVFAE TYENQTKLAL
VGNWGTTGLT YPKFSDVTGK IKLPKDSFRP SAGWTWAGDW FVCPEKTLLH DIDAGHLSFV
EEVFENQTRL PGGQWIYMSD NYTDVNGEKV LPKDDIECPL GWKWEDEEWS TDLNRAVDEQ
GWEYSIPIPP DRKPKHWVPA EKMYYTHRRR RWVRLRRRDL SQMEALKRHR QAEAEGEGWE
YASLFGWKFH LEYRKTDAFR RRRWRRRMEP LEKTGPAAVF ALEGALGGVV DDKSEDSMSV
STLSFGVNRP TISCIFDYGN RYHLRCYMYQ ARDLPSMDKD SFSDPYAIVS FLHQSQKTVV
AKNTLNPTWD QTLIFYEIEI FGEPASIAEQ PPSIVVELYD HDTYGADEFM GRCICQPSLE
RMPRLAWFPL IRGSQPAGEL LASFELIQRE KPAIHHIPGF EVQDTSGILE ESEDTDLPYP
PPQREANIYM VPQNIKPVLQ RTAIEILAWG LRNMKSYQLA SISSPSLVVE CGGQTVQSCV
IKNLRKNPNF DICTLFMEVM LPREELYCPP IVIKVIDNRQ FGRRPVVGQC TVRSLESFMC
DQYSEESPSP QGGPDDVSLL SPGEDVLIDI DDKEPLIPIQ LADGLSGSAP TNMASSPSSP
HEEEFIDWWS KFFASTGERE KCGQYLEKGF DTLKVYDTQL ENVEAFEGLS DFCNTFKLYR
GKTQEETEDP SVIGEFKGLF KIYPLPEDPA IPMPPRQFHQ LAAQGPQECL VRIYIIRAFG
LQPKDPNGKC DPYIKISIGK KSVSDQDNYI PCTLEPVFGK MFELTCTLPL EKDLKITLYD
YDLLSKDEKI GETVIDLENR LLSKFGARCG LPQTYCVSGP NQWRDQLRPS QLLHLFCQQR
RVKAPVYHTD RVVFEDKEYT IEEIEAGKVL NPHLGPVEER LALYVLQQQG LVPEHVESRP
LYSPLQPDIE QGKLQMWIDL FPKALGRPGP PFNITPRRAR RFFLRCIIWN TKDVILDDLS
ITGEKMSDIY VKGWMVGFEE HKQKTDVHYR SLGGEGNFNW RFIFPFDYLP AEQVCTVSKK
DAFWRLDKTE SKIPARVIFQ IWDNDKFSFD DFLGSLQLDL NHMPKPAKTA EKCSLDQLDG
TFHPEWFVSL FEQKTVKGWW PCVAEEGEKK ILAGKLEMTL EIVAESEHEE RPAGQGRDEP
NMNPKLEDPR RPDTSFLWFT SPYKTMKFIL WRRFRCAIIL FIILFILLLF LGIFVYAFPN
YAAMKLVKPF S
//
