ID A0A2I2V4H6_FELCA Unreviewed; 1170 AA.
AC A0A2I2V4H6;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=WD repeat-containing protein 35 {ECO:0000256|PIRNR:PIRNR037536};
GN Name=WDR35 {ECO:0000313|Ensembl:ENSFCAP00000039559.1,
GN ECO:0000313|VGNC:VGNC:67028};
OS Felis catus (Cat) (Felis silvestris catus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Feliformia; Felidae; Felinae; Felis.
OX NCBI_TaxID=9685 {ECO:0000313|Ensembl:ENSFCAP00000039559.1, ECO:0000313|Proteomes:UP000011712};
RN [1] {ECO:0000313|Ensembl:ENSFCAP00000039559.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000039559.1,
RC ECO:0000313|Proteomes:UP000011712};
RX PubMed=17975172; DOI=10.1101/gr.6380007;
RA Pontius J.U., Mullikin J.C., Smith D.R., Lindblad-Toh K., Gnerre S.,
RA Clamp M., Chang J., Stephens R., Neelam B., Volfovsky N., Schaffer A.A.,
RA Agarwala R., Narfstrom K., Murphy W.J., Giger U., Roca A.L., Antunes A.,
RA Menotti-Raymond M., Yuhki N., Pecon-Slattery J., Johnson W.E., Bourque G.,
RA Tesler G., O'Brien S.J.;
RT "Initial sequence and comparative analysis of the cat genome.";
RL Genome Res. 17:1675-1689(2007).
RN [2] {ECO:0000313|Ensembl:ENSFCAP00000039559.1, ECO:0000313|Proteomes:UP000011712}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000039559.1,
RC ECO:0000313|Proteomes:UP000011712};
RA Hillier L.W., Warren W., Obrien S., Wilson R.K.;
RT "Sequence assembly of the Felis catus genome version 6.2.";
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Ensembl:ENSFCAP00000039559.1}
RP IDENTIFICATION.
RC STRAIN=breed Abyssinian {ECO:0000313|Ensembl:ENSFCAP00000039559.1};
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: As a component of the IFT complex A (IFT-A), a complex
CC required for retrograde ciliary transport and entry into cilia of G
CC protein-coupled receptors (GPCRs), it is involved in ciliogenesis and
CC ciliary protein trafficking. {ECO:0000256|PIRNR:PIRNR037536}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000256|PIRNR:PIRNR037536}. Cytoplasm,
CC cytoskeleton, cilium basal body {ECO:0000256|PIRNR:PIRNR037536}.
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DR EMBL; AANG04003329; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_011279609.1; XM_011281307.2.
DR AlphaFoldDB; A0A2I2V4H6; -.
DR PaxDb; 9685-ENSFCAP00000004963; -.
DR Ensembl; ENSFCAT00000047457.3; ENSFCAP00000039559.1; ENSFCAG00000005351.6.
DR GeneID; 101083332; -.
DR KEGG; fca:101083332; -.
DR CTD; 57539; -.
DR VGNC; VGNC:67028; WDR35.
DR GeneTree; ENSGT00940000155745; -.
DR OrthoDB; 148480at2759; -.
DR Proteomes; UP000011712; Chromosome A3.
DR Bgee; ENSFCAG00000005351; Expressed in testis and 10 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:UniProtKB-SubCell.
DR GO; GO:0036064; C:ciliary basal body; IEA:UniProtKB-UniRule.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030991; C:intraciliary transport particle A; IEA:UniProtKB-UniRule.
DR GO; GO:0060271; P:cilium assembly; IEA:InterPro.
DR GO; GO:0035721; P:intraciliary retrograde transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.40.470; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR024977; Apc4-like_WD40_dom.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039857; Ift122/121.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR017233; WDR35.
DR PANTHER; PTHR12764:SF5; LD29485P; 1.
DR PANTHER; PTHR12764; WD REPEAT DOMAIN-RELATED; 1.
DR Pfam; PF12894; ANAPC4_WD40; 1.
DR Pfam; PF00400; WD40; 1.
DR PIRSF; PIRSF037536; WD_repeat_p35; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF69322; Tricorn protease domain 2; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Cell projection {ECO:0000256|PIRNR:PIRNR037536};
KW Cilium {ECO:0000256|PIRNR:PIRNR037536};
KW Cilium biogenesis/degradation {ECO:0000256|PIRNR:PIRNR037536};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR037536};
KW Cytoskeleton {ECO:0000256|PIRNR:PIRNR037536};
KW Reference proteome {ECO:0000313|Proteomes:UP000011712};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 67..98
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 130..194
FT /note="Anaphase-promoting complex subunit 4-like WD40"
FT /evidence="ECO:0000259|Pfam:PF12894"
SQ SEQUENCE 1170 AA; 132510 MW; 27798A8DC2F6A65E CRC64;
MFFYLSKKVA IPDNVKLKCV SWNKDQGFIA CGGEDGLLKV LKLETQTDDA KLRGLAVPSN
LSMNQNLEGH SGSVQVVTWN EQYQKLTTSD QNGLIIVWML YKGSWYEEMI NNRNKSVVRS
MSWNADGQKI CIVYEDGAVI VGSVDGNRIW GKDLKGVQLC HVAWSADSKI LLFGMTSGEI
HIYDNQGNFI MKMKLNCLVN VTGAISIAGI HWYHGQEGYV EPDCPCLAIC FDNGRCQIMR
HENDQNPVLI DTGMFVVSIQ WNHTGSVLAV AGSQKVVTQD KDVNTVQFYT PFGEHLGTLK
VPGKQMSALS WEGGGLKIAL AVDSFIYFAN IRPDYKWGYC SNTVVYAYTR PDRPEYCVIF
WDTKNNEKYV KYVKSLISIT TCGDFCILAT KADENHPQFV LVLCNSIGTP LDPKYIDIVP
LFVAMTKTHV IAASKEAFYT WQYRVAKKLT ALEINQITRS RKEGRERIYH VDDTPSGSVD
GVLDYSKAIQ GTRDPICAIT ASDKTLIVGR ESGTIQRYSL PNVGLIQKYS LNCRAYQLSL
NCNSSRLAII DISGVLTFFD LDARVTDSTG QQVIGELLKL ERKDVWDMKW AKDNPDLFAM
MEKTRMYVFR NLDPEEPIQT SGYICIFEDL EIKSVLLDEI LKNPEHPNKD YIINFEIRSL
RDSRALIEKV GIEDASQFIE DNPHPRLWRL LAEAALQKLD LHTAEQAFVR CKDYQGIKFV
KRLGNLQSES MKQAEVAAYF GRFEEAERMY LDMDRRDLAI GLRLKLGDWF RVLQLLKTGS
GDADDSLLEQ AHNAIGDYFA DRQKWLNAVQ YYVQGRNQER LAECYYMLED YEGLENLASS
LPENHKLLPE IAQMFVRVGM CEQAVTAFLK CNQPKAAVDT CVHLNQWNKA VELAKNHSMK
EIGSLLARYA SHLLEKNKTL DAIELYRKAN YFYDAAKLMF KIADEEAKKR TKPLRVKKLY
VLSALLIEQY HEQVRNAQRG KVKGKSSEAT SALAGLLEEE VLSTTSRFRD NAWRGAEAYH
FFTLAQRQLY EGYVDTALKT ALHLRDYEDI IPAVEIYSLL ALCACAGRAF GTCSKAFIKL
ESLETLSSEQ KQQYEDLALE IFTKHPPKDN RKSELDSLLE GGEGKLPTCV ATGSPITEYQ
FWVCNVCKHC VLAQEISNYN FCPLCHSSVG
//
