ID A0A2I2Y251_GORGO Unreviewed; 1430 AA.
AC A0A2I2Y251;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=FYVE, RhoGEF and PH domain containing 6 {ECO:0000313|Ensembl:ENSGGOP00000028973.1};
GN Name=FGD6 {ECO:0000313|Ensembl:ENSGGOP00000028973.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000028973.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000028973.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000028973.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000028973.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; CABD030086085; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030086086; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030086087; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030086088; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030086089; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030086090; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030086091; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030086092; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030086093; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030086094; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018894900.1; XM_019039355.1.
DR STRING; 9593.ENSGGOP00000028973; -.
DR Ensembl; ENSGGOT00000053416.1; ENSGGOP00000028973.1; ENSGGOG00000012410.3.
DR GeneID; 101124162; -.
DR KEGG; ggo:101124162; -.
DR CTD; 55785; -.
DR GeneTree; ENSGT00940000156334; -.
DR InParanoid; A0A2I2Y251; -.
DR OMA; YILPMSS; -.
DR OrthoDB; 5385125at2759; -.
DR Proteomes; UP000001519; Chromosome 12.
DR Bgee; ENSGGOG00000012410; Expressed in liver and 5 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd15743; FYVE_FGD6; 1.
DR CDD; cd15793; PH1_FGD6; 1.
DR CDD; cd13237; PH2_FGD5_FGD6; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR037743; FGD6_N_PH.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF12; FYVE, RHOGEF AND PH DOMAIN-CONTAINING PROTEIN 6; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 871..1060
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 1089..1183
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1222..1281
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 1333..1429
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 1..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 329..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 695..739
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 799..869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 21..35
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 331..351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 807..822
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 827..843
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 845..869
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1430 AA; 160738 MW; AD1E7BF65E95891C CRC64;
MTSAAEIKKP PVAPKPKFVV ANNKPAPPPI APKPDIVISS VPQSTKKMKP AIAPKPKVLK
TSPVRDIGQS PSRKIMLNLE GHKQELAEST DNFNCKYEGS QSSDYISPMC SCSSECIHKL
GHRENLCVKQ LVLEPLEMNE NLENSKIDET LTIKTRSKCD FYGEKAKNQG GVVLKASVLE
EELKDALIHQ MPPFISAQKH RPTDSPEVNG GCNSNGQFRI EFADLSPSPS SFEKVPDHHS
CHLQLPSDEC EHFETCQDDS EKSNNCFQSS ELEALENGKR STLISSDGVS KKSEVKDLGP
LEIHLVPYTP KFPTPKPRKT RTARLLRQKC VDTPSESTEE PGNSDSSSSC LTENSLKINK
INVLHQNVLC KQEQVDKMKL GNKSELNMES NSDAQDLVNS QKAMCDETTS VEKMAPSFDT
DSNLSSDSTT VDGSSMSLAV DEGTGFIRCT VSMSLPKQLK LTCNEHLQSG RNLGVSAPQM
QKESVIKEEN SLRIVPKKPQ RHSLPATGVL KKAASEELLE KSSYPSSEEK NSEKSLERNH
LQHLCAQNRG VSSSFDMPKR ASEKPVWKLP HPILPFSGNP EFLKSVTVSS NSEPSTALTK
PRAKSLSAMD VEKCTKPCKD STKKNSFKKL LSMKLSICFM KSDFQKFWSK SSQLGDTTTG
HLSSGEQKGI ESDWQGLLVG EEKRSKPIKA YSTENYSLES QKKRKKSRGQ TSAANGLRAE
SLDDQMLSRE SSSQAPYKSV TSLCAPEYEN IRHYEEIPEY ENLPFIMAIR KTQELEWQNS
SSMEDADASV YEVEEPYEAP DGQLQLGPRH QRSSSGASQE EQNDLGLGDL PSDEEEVINS
SDEDDVSSES SKGEPDPLED KQDEDNGMKS KVHHIAKEIM SSEKVFVDVL KLLHIDFRDA
VAHASRQLGK PVIEDRILNQ ILYYLPQLYE LNRDLLKELE ERMLHWTEQQ RIADIFVKKG
PYLKMYSTYI KEFDKNIALL DEQCKKNPGF AAVVREFEMS PRCANLALKH YLLKPVQRIP
QYRLLLTDYL KNLIEDAGDY RDTQDALAVV IEVANHANDT MKQGDNFQKL MQIQYSLNGH
HEIVQPGRVF LKEGILMKLS RKVMQPRMFF LFNDALLYTT PVQSGMYKLN NMLSLAGMKV
RKPTQEAYQN ELKIESVERS FILSASSATE RDEWLEAISR AIEEYAKKRI TFCPSRSLDE
ADSENKEEVS PLGSKAPIWI PDTRATMCMI CTSEFTLTWR RHHCRACGKI VCQACSSNKY
GLDYLKNQPA RVCEHCFQEL QKLDHQHSPR IVSPGNHKSP SSALSSVLHS IPSGRKQKKI
PAALKEVSAN TEDSSMSGYL YRSKGNKKPW KHFWFVIKNK VLYTYAASED VAALESQPLL
GFTVTQVKDE NSESKVFQLL HKNMLFYVFK AEDAHSAQKW IEAFQEGTIL
//
