ID A0A2I2Y2R5_GORGO Unreviewed; 1166 AA.
AC A0A2I2Y2R5;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=PTPRF interacting protein alpha 2 {ECO:0000313|Ensembl:ENSGGOP00000029174.1};
GN Name=PPFIA2 {ECO:0000313|Ensembl:ENSGGOP00000029174.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000029174.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000029174.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000029174.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000029174.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the liprin family. Liprin-alpha subfamily.
CC {ECO:0000256|ARBA:ARBA00007026}.
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DR EMBL; CABD030085696; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030085697; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030085698; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030085699; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2Y2R5; -.
DR Ensembl; ENSGGOT00000045954.1; ENSGGOP00000029174.1; ENSGGOG00000026460.2.
DR GeneTree; ENSGT01050000244900; -.
DR Proteomes; UP000001519; Chromosome 12.
DR Bgee; ENSGGOG00000026460; Expressed in prefrontal cortex and 3 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR CDD; cd09562; SAM_liprin-alpha1_2_3_4_repeat1; 1.
DR CDD; cd09565; SAM_liprin-alpha1_2_3_4_repeat2; 1.
DR CDD; cd09568; SAM_liprin-alpha1_2_3_4_repeat3; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 3.
DR InterPro; IPR029515; Liprin.
DR InterPro; IPR037620; Liprin-alpha_SAM_rpt_1.
DR InterPro; IPR037621; Liprin-alpha_SAM_rpt_2.
DR InterPro; IPR037622; Liprin-alpha_SAM_rpt_3.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR12587; LAR INTERACTING PROTEIN LIP -RELATED PROTEIN; 1.
DR PANTHER; PTHR12587:SF6; LIPRIN-ALPHA-2; 1.
DR Pfam; PF00536; SAM_1; 2.
DR Pfam; PF07647; SAM_2; 1.
DR SMART; SM00454; SAM; 3.
DR SUPFAM; SSF47769; SAM/Pointed domain; 3.
DR SUPFAM; SSF57997; Tropomyosin; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 3.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 817..883
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 946..1003
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 1027..1096
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT REGION 157..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 365..390
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 629..657
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 30..71
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 122..156
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 570..611
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 161..178
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..647
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1166 AA; 133091 MW; 937517A75ACFCD02 CRC64;
VLDTGGVTVN KSKPLSTWSL PCRKTEQYEF AALTKELNAC REQLLEKEEE ISELKAERNN
TRLLLEHLEC LVSRHERSLR MTVVKRQAQS PSGVSSEVEV LKALKSLFEH HKALDEKVRE
RLRVSLERVS ALEEELAAAN QEIVALREQN VHIQRKMASS EGSTESEHLE GVEPGQKVHE
KRLSNGSIDS TDETSQIVEL QELLEKQNYE MAQMKERLAA LSSRVGEVEQ EAETARKDLI
KTEEMNTKYQ RDIREAMAQK EDMEERITTL EKRYLSAQRE STSIHDMNDK LENELANKEA
ILRQMEEKNR QLQERLELAE QKLQQTMRKA ETLPEVEAEL AQRIAALTKA EERHGNIEER
MRHLEGQLEE KNQELQRARQ REKMNEEHNK RLSDTVDRLL TESNERLQLH LKERMAALEE
KTFVSSLLYL RCLTHKRLAE EIEKLRSELD QLKMRTGSLI EPTIPRTHLD TSAELRYSVG
SLVDSQSDYR TTKVIRRPRR GRMGVRRDEP KVKSLGDHEW NRTQQIGVLS SHPFESDTEM
SDIDDDDRET IFSSMDLLSP SGHSDAQTLA MMLQEQLDAI NKEIRLIQEE KESTELRAEE
IENRVASVSL EGLNLARVHP GTSITASVTA SSLASSSPPS GHSTPKLTPR SPAREMDRMG
VMTLPSDLRK HRRKIAVVEE DGREDKATIK CETSPPPTPR ALRMTHTLPS SYHNDARSLS
VSLEPESLGL RSANSSQDSL HKAPKKKGIK SSIGRLFGKK EKARLGQLRG FMETEAAAQE
SLGLGKLGTQ AEKDRRLKKK HELLEEARRK GLPFAQWDGP TVVAWLELWL GMPAWYVAAC
RANVKSGAIM SALSDTEIQR EIGISNPLHR LKLRLAIQEM VSLTSPSAPP TSRTPSGNVW
VTHEEMENLA APAKTKESEE GSWAQCPVFL QTLAYGDMNH EWIGNEWLPS LGLPQYRSYF
MECLVDARML DHLTKKDLRV HLKMVDSFHR TSLQYGIMCL KRLNYDRKEL ERRREASQHE
IKDVLVWSND RVIRWIQAIG LREYANNILE SGVHGSLIAL DENFDYSSLA LLLQIPTQNT
QARQILEREY NNLLALGTER RLDESDDKNF RRGSTWRRQF PPREVHGISM MPGSSETLPA
GFRLTTTSGQ SRKMTTDDGV FSVYST
//
