ID A0A2I2Y2S3_GORGO Unreviewed; 606 AA.
AC A0A2I2Y2S3;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Protein Smaug homolog 1 {ECO:0000256|ARBA:ARBA00041183};
DE AltName: Full=Sterile alpha motif domain-containing protein 4A {ECO:0000256|ARBA:ARBA00041298};
GN Name=SAMD4A {ECO:0000313|Ensembl:ENSGGOP00000029205.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000029205.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000029205.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000029205.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000029205.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Synapse, synaptosome {ECO:0000256|ARBA:ARBA00034102}.
CC -!- SIMILARITY: Belongs to the SMAUG family.
CC {ECO:0000256|ARBA:ARBA00008232}.
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DR EMBL; CABD030092402; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030092403; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030092404; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2Y2S3; -.
DR Ensembl; ENSGGOT00000048878.1; ENSGGOP00000029205.1; ENSGGOG00000000673.3.
DR GeneTree; ENSGT00940000157933; -.
DR Proteomes; UP000001519; Chromosome 14.
DR Bgee; ENSGGOG00000000673; Expressed in testis and 5 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0043005; C:neuron projection; IEA:UniProtKB-KW.
DR GO; GO:0045202; C:synapse; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0030371; F:translation repressor activity; IEA:InterPro.
DR GO; GO:0043488; P:regulation of mRNA stability; IEA:InterPro.
DR CDD; cd09557; SAM_Smaug; 1.
DR Gene3D; 1.25.40.170; Smaug, PHAT domain; 2.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR037093; PHAT_dom_sf.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR037634; Smaug_SAM.
DR PANTHER; PTHR12515:SF8; PROTEIN SMAUG HOMOLOG 1; 1.
DR PANTHER; PTHR12515; STERILE ALPHA MOTIF DOMAIN CONTAINING PROTEIN 4-RELATED; 1.
DR Pfam; PF00536; SAM_1; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repressor {ECO:0000256|ARBA:ARBA00022491};
KW Synapse {ECO:0000256|ARBA:ARBA00022599};
KW Synaptosome {ECO:0000256|ARBA:ARBA00022599};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845}.
FT DOMAIN 219..282
FT /note="SAM"
FT /evidence="ECO:0000259|SMART:SM00454"
FT REGION 177..222
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 316..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 460..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..219
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 606 AA; 66735 MW; A831333EEE6B1186 CRC64;
MKLLPKILAH SIEHNQHIEE SRQLLSYALI HPATSLEDRS ALAMWLNHLE DRTSTSFGGQ
NRGRSDSVDY GQTHYYHQRQ NSDDKLNGWQ NSRDSGICIN ASNWQDKSMG CENGHVPLYS
SSSVPTTINT IGTSTSTILS GQAHHSPLKR SVSLTPPMNV PNQPLGHGWM SHEDLRARGP
QCLPSDHAPL SPQSSVASSG SGGSEHLEDQ TTARNTFQEE GSGMKDVPAW LKSLRLHKYA
ALFSQMTYEE MMALTECQLE AQNVTKGARH KIVISIQKLK ERQNLLKSLE RDIIEGGSLR
IPLQELHQMI LTPIKAYSSP STTPEARRRE PQSQSPDCKD GAAATGATAT PSAGASGGLQ
PHQLSSCDGE LAVAPLPEGD LPGQFTRVMG KVCTQLLVSR PDEENISSYL QLIDKCLIHE
AFTETQKKRL LSWKQQVQKL FRSFPRKTLL DISGYRQQRN RGFGQSNSLP TAGSVGGGMG
RRNPRQYQIP SRNVPSARLG LLGTSGFVSS NQRNTTAAPT IMKQGRQNLW FANPGGSNSM
PSRTHSSVQR TRSLPVHTSP QNMLMFQQPE FQLPVTEPDI NNRLESLCLS MTEHALGDGV
DRTSTI
//
