ID A0A2I2Y2T3_GORGO Unreviewed; 984 AA.
AC A0A2I2Y2T3;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=MCF.2 cell line derived transforming sequence like {ECO:0000313|Ensembl:ENSGGOP00000029215.1};
GN Name=MCF2L {ECO:0000313|Ensembl:ENSGGOP00000029215.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000029215.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000029215.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000029215.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000029215.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR EMBL; CABD030090955; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030090956; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030090957; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030090958; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030090959; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030090960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030090961; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030090962; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030090963; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2Y2T3; -.
DR Ensembl; ENSGGOT00000066658.1; ENSGGOP00000029215.1; ENSGGOG00000014036.3.
DR GeneTree; ENSGT00940000157874; -.
DR Proteomes; UP000001519; Chromosome 13.
DR Bgee; ENSGGOG00000014036; Expressed in cerebellum and 6 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd01227; PH_Dbs; 1.
DR CDD; cd00160; RhoGEF; 1.
DR CDD; cd00170; SEC14; 1.
DR CDD; cd00176; SPEC; 1.
DR Gene3D; 1.20.58.60; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR035534; DBS_PH.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR22826:SF115; GUANINE NUCLEOTIDE EXCHANGE FACTOR DBS; 1.
DR PANTHER; PTHR22826; RHO GUANINE EXCHANGE FACTOR-RELATED; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF00435; Spectrin; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00516; SEC14; 1.
DR SMART; SM00150; SPEC; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF46966; Spectrin repeat; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..984
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014144873"
FT DOMAIN 20..192
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 599..779
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 797..913
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 525..593
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 923..984
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 569..593
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 923..949
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 984 AA; 111794 MW; 13D080280BD4E257 CRC64;
MTVSRLSLLC RDLWALWLLL KAGADEIMHQ DIVPLCAADI QDQLKKRFAY LSGGRGQDGS
PVITFPDYPA FSEIPDKEFQ NVMTYLTSIP SLQDAGIGFI LVIDRRRDKW TSVKASVLRI
AASFPANLQL VLVLRPTGFF QRTLSDIAFK FNRDDFKMKV PVIMLSSVPD LHGYIDKSQL
TEDLGGTLDY CHSRWLCQRT AIESFALMVK QTAQMLQSFG TELAETELPN DVQSTSSVLC
AHTEKKDKAK EDLRLALKEG HSVLESLREL QAEGSEPSVN QDQLDNQATV QRLLAQLNET
EAAFDEFWAK HQQKLEQCLQ LRHFEQGFRE VKAILDAASQ KIATFTDIGN SLAHVEHLLR
DLASFEEKSG VAVERARALS LDGEQLIGNK HYAVDSIRPK CQELRHLCDQ FSAEIARRRG
LLSKSLELHR RLETSMKWCD EGIYLLASQP VDKCQSQDGA EAALQEIEKF LETGAENKIQ
ELSAIYKEYE SILNQDLMEH VRKVFQKQAS MEEVFHRRQA SLKKLAARQT RPVQPVAPRP
EALAKSPCPS PGIRRGSENS SSEGGALRRG PYRRAKSEMS ESRQGRGSAG EEEESLAILR
RHVMSELLDT ERAYVEELLC VLEGYAAEMD NPLMAHLLST GLHNKKDVLF GNMEEIYHFH
NRIFLRELEN YTDCPELVGR CFLERMEDFQ IYEKYCQNKP RSESLWRQCS DCPFFQECQR
KLDHKLSLDS YLLKPVQRIT KYQLLLKEML KYSRNCEGAE DLQEALSSIL GILKAVNDSM
HLIAITGYDG NLGDLGKLLM QGSFSVWTDH KRGHTKVKEL ARFKPMQRHL FLHEKAVLFC
KKREENGEGY EKAPSYSYKQ SLNMAAVGIT ENVKGDAKKF EIWYNAREEV YIVQAPTPEI
KAAWVNEIRK VLTSQLQACR EASQHRALEQ SQSLPLPAPT STSPSRGNSR NIKKLEERKT
DPLSLEGYVS SVPLTKPPEK GKEP
//
