ID A0A2I2Y411_GORGO Unreviewed; 335 AA.
AC A0A2I2Y411;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=nucleoside-diphosphate kinase {ECO:0000256|ARBA:ARBA00012966};
DE EC=2.7.4.6 {ECO:0000256|ARBA:ARBA00012966};
GN Name=AK9 {ECO:0000313|Ensembl:ENSGGOP00000029614.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000029614.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000029614.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000029614.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000029614.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBUNIT: Monomer. {ECO:0000256|ARBA:ARBA00011245}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CABD030047200; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030047201; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030047202; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030047203; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030047204; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030047205; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030047206; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030047207; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030047208; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030047209; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2Y411; -.
DR Ensembl; ENSGGOT00000049915.1; ENSGGOP00000029614.1; ENSGGOG00000022458.2.
DR GeneTree; ENSGT00740000115564; -.
DR Proteomes; UP000001519; Chromosome 6.
DR Bgee; ENSGGOG00000022458; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004550; F:nucleoside diphosphate kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0009123; P:nucleoside monophosphate metabolic process; IEA:UniProt.
DR GO; GO:0009117; P:nucleotide metabolic process; IEA:UniProt.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd01428; ADK; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR000850; Adenylat/UMP-CMP_kin.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR23359; NUCLEOTIDE KINASE; 1.
DR PANTHER; PTHR23359:SF206; UMP-CMP KINASE; 1.
DR Pfam; PF13238; AAA_18; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT REGION 316..335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 121..152
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 335 AA; 38969 MW; AFB5FAB7FE94597B CRC64;
MKERKRHLGD TKHFCPVVLK ENFILQPGNT EEAAKYREKI YYFSSAEAKE KFLEHPEDYV
AHKEPLKAPP LRICLVGPQG SGKTMCGRQL AEKLNIFHIQ FEEVLQEKLL LKTEKKVGPE
FEEDSEDEQA AKQELEELAI QANVKVEEEN TKKQLPEVQL TEEEEVIKSS LMENEPLPPE
ILEVILSEWW LKEPIRSTGF ILDGFPRYPE EAQFLGDRGF FPDVAVFIQV DDQDIFDRLL
PAQIEKWKLK QKKKLERKKL IKDMKAKIRV DTIAKRRAEL ILERDKKRRE VSNVFFFKTG
SHSVAQVRVQ WHNHSSLQPR TPGLKGSSHL SLSKC
//
