ID A0A2I2Y4I3_GORGO Unreviewed; 453 AA.
AC A0A2I2Y4I3;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=DnaJ homolog subfamily C member 3 {ECO:0000256|ARBA:ARBA00039409};
GN Name=DNAJC3 {ECO:0000313|Ensembl:ENSGGOP00000029808.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000029808.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000029808.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000029808.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000029808.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030090433; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030090434; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030090435; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030090436; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030090437; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030090438; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030090439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030090440; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030090441; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030090442; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2Y4I3; -.
DR Ensembl; ENSGGOT00000064218.1; ENSGGOP00000029808.1; ENSGGOG00000001314.3.
DR GeneTree; ENSGT00940000159806; -.
DR Proteomes; UP000001519; Chromosome 13.
DR Bgee; ENSGGOG00000001314; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0006986; P:response to unfolded protein; IEA:UniProtKB-KW.
DR CDD; cd06257; DnaJ; 1.
DR Gene3D; 1.10.287.110; DnaJ domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR InterPro; IPR001623; DnaJ_domain.
DR InterPro; IPR036869; J_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR44140:SF3; DNAJ HOMOLOG SUBFAMILY C MEMBER 3; 1.
DR PANTHER; PTHR44140; LD25575P; 1.
DR Pfam; PF00226; DnaJ; 1.
DR Pfam; PF13432; TPR_16; 2.
DR Pfam; PF14559; TPR_19; 1.
DR Pfam; PF13181; TPR_8; 1.
DR PRINTS; PR00625; JDOMAIN.
DR SMART; SM00271; DnaJ; 1.
DR SMART; SM00028; TPR; 7.
DR SUPFAM; SSF46565; Chaperone J-domain; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS50076; DNAJ_2; 1.
DR PROSITE; PS50005; TPR; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803, ECO:0000256|PROSITE-
KW ProRule:PRU00339};
KW Unfolded protein response {ECO:0000256|ARBA:ARBA00023230}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..453
FT /note="DnaJ homolog subfamily C member 3"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014197859"
FT REPEAT 37..70
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 171..204
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT REPEAT 289..322
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 343..411
FT /note="J"
FT /evidence="ECO:0000259|PROSITE:PS50076"
FT REGION 400..430
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 453 AA; 51926 MW; C8FC40D767AA530B CRC64;
MVAPGSVTSR LGSVFPFLLV LVDLQYEGAE CGVNADVEKH LELGKKLLAA GQLADALSQF
HAAVDGDPDN YIAYYRRATV FLAMGKSKAA LPDLTKVIQL KMDFTAARLQ RGHLLLKQGK
LDEAEDDFKK VVCVWDAELR ELRAECFIKE GEPRKAISDL KAASKLKNDN TEAFYKISTL
YYQLGDHELS LSEVRECLKL DQDHKRCFAH YKQVKKLNKL IESAEELIRD GRYTDATSKY
ESVMKTEPSI AEYTIRSKER ICHCFSKDEK PVEAIRVCSE VLQMEPDNVN ALKDRAEAYL
IEEMYDEAIQ DYETAQEHNE NDQQIREGLE KAQRLLKQSQ KRDYYKILGV KRNAKKQEII
KAYRKLALQW HPDNFQNEEE KKKAEKKFID IAAAKEVLSD PEMRKKFDDG EDPLDAESQQ
GGGGNPFHRS WNSWQGFNPF SSGGPFRFKF HFN
//
