ID A0A2I2Y6A2_GORGO Unreviewed; 1106 AA.
AC A0A2I2Y6A2;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=RP1 axonemal microtubule associated {ECO:0000313|Ensembl:ENSGGOP00000030417.1};
GN Name=RP1 {ECO:0000313|Ensembl:ENSGGOP00000030417.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000030417.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000030417.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000030417.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000030417.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CABD030058800; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030058801; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030058802; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030058803; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030058804; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030058805; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2Y6A2; -.
DR Ensembl; ENSGGOT00000054214.1; ENSGGOP00000030417.1; ENSGGOG00000012280.3.
DR GeneTree; ENSGT00940000154242; -.
DR Proteomes; UP000001519; Chromosome 8.
DR Bgee; ENSGGOG00000012280; Expressed in testis and 1 other cell type or tissue.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd17145; DCX1_RP1; 1.
DR CDD; cd17147; DCX2_RP1; 1.
DR CDD; cd01756; PLAT_repeat; 2.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 2.40.180.10; Catalase core domain; 1.
DR Gene3D; 3.10.20.230; Doublecortin domain; 2.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 3.
DR InterPro; IPR003533; Doublecortin_dom.
DR InterPro; IPR036572; Doublecortin_dom_sf.
DR InterPro; IPR008996; IL1/FGF.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR PANTHER; PTHR45901:SF7; LIPOXYGENASE HOMOLOGY DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45901; PROTEIN CBG12474; 1.
DR Pfam; PF03607; DCX; 2.
DR Pfam; PF01477; PLAT; 4.
DR SMART; SM00537; DCX; 2.
DR SMART; SM00308; LH2; 4.
DR SUPFAM; SSF50353; Cytokine; 2.
DR SUPFAM; SSF89837; Doublecortin (DC); 2.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 4.
DR PROSITE; PS50309; DC; 2.
DR PROSITE; PS50095; PLAT; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 36..118
FT /note="Doublecortin"
FT /evidence="ECO:0000259|PROSITE:PS50309"
FT DOMAIN 154..233
FT /note="Doublecortin"
FT /evidence="ECO:0000259|PROSITE:PS50309"
FT DOMAIN 264..380
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 392..509
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 856..970
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT DOMAIN 982..1099
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 801..840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 811..828
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1106 AA; 123634 MW; CB23A5C04B82214E CRC64;
MSDTPSTGFS IIHPTSSEGQ VPPPRHLSLT HPVVAKRISF YKSGDPQFGG VRVVVNPRSF
KSFDALLDNL SRKVPLPFGV RNISTPRGRH SITRLEELED GESYLCSHGR KVQPVDLDKA
RRRPRPWLSS RAISAHSPPH AVAVAAPGMP RPPRSLVVFR NGDPKTRRAV LLSRRVTQSF
EAFLQHLTEV MQRPVVKLYA TDGRRVPSLQ AVILSSGAVV AAGREPFKPG NYDIQKYLLP
ARLPGISQRV YPKGNAKSES RKSSNWKVFI ITSDLPDAGT SSQIYIILYG QHRSSAPIYL
YGTDGARFQV GHEDIFTITV GDIGALFKIR IGHTNSGPSP SWHCKEIQLH NMNSGKQFYV
PVQRWLARDQ EDGEICREFP LLSKGQPVLP VTIYEVNVAT GELWNARTVA NVYISIHGEK
GDTGSRQLFR SKSSFNFLRG QTDTFFLEAV HLGDLCKIVI GHDGLGPGNG WFLDDVVIKD
PTTNYEYAFF CHRWLDQGED DCKIVRELYA RDNSIFSARQ KLELKRKETW TAESWKFTKG
NTLQFYNKLT GGFVRLHPDG TVDAIGEKTD KYGVFDVIFN KRNICIFQSH EMRHLSLALD
NGIVTGMVSG EATTELRVLY QPNRCALLES ALVPGHTVVF DRHGKIADAS SAGYANLSKE
FVIFVKGVFL NSAVVLLATS LCQALCLQPD GSCTGVGSQS EKSYWKVHKI SSGICMFESV
KNAQMYLRIK DGRCDGTGTG DVDCHFKIKK NLKNASISLE STKSPGLFVG LQSDGQAKPM
IYTKDENVCF YPQVIQFGRE NPMGMSATPS QEEEKIHESK KQKKIPPESE ARSPLPSSTA
KEIRHFQSSE TLLSEGEWKV LVLTGNTGTQ ANVTLWVYGD KGVTGPISLC KDSSEQLFLP
GHEDEFQVEI RNIGNIYKIR IGHDGTSEQP EWNLQRVTMQ HTKSKKILDF AANVWLSRIQ
ADGDVVCELP VVKGGQAIFP LVRYQVDVYT GQLKHAETES EVFLCLFGER GDSGLRQLYK
SNMQVKFQRG QIDKFQVAAV SLGKLQKVLL RCEASDKSQY WYCEQVIVRE PGTTSESIFT
CQRWLPFMSQ GIIHSEIELY LQGEDY
//
