ID A0A2I2Y937_GORGO Unreviewed; 2215 AA.
AC A0A2I2Y937;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRB {ECO:0000313|Ensembl:ENSGGOP00000031414.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000031414.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000031414.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000031414.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000031414.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 3 subfamily. {ECO:0000256|ARBA:ARBA00025789}.
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DR EMBL; CABD030085341; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030085342; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030085343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030085344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030085345; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004053610.1; XM_004053562.2.
DR STRING; 9593.ENSGGOP00000031414; -.
DR Ensembl; ENSGGOT00000043113.1; ENSGGOP00000031414.1; ENSGGOG00000006298.3.
DR GeneID; 101138659; -.
DR KEGG; ggo:101138659; -.
DR CTD; 5787; -.
DR GeneTree; ENSGT00940000156088; -.
DR InParanoid; A0A2I2Y937; -.
DR OMA; TRHQTNT; -.
DR OrthoDB; 5402037at2759; -.
DR Proteomes; UP000001519; Chromosome 12.
DR Bgee; ENSGGOG00000006298; Expressed in heart and 5 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0045296; F:cadherin binding; IBA:GO_Central.
DR GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0001525; P:angiogenesis; IBA:GO_Central.
DR GO; GO:0016311; P:dephosphorylation; IEA:Ensembl.
DR CDD; cd00063; FN3; 11.
DR CDD; cd14617; R-PTPc-B; 1.
DR CDD; cd00161; RICIN; 1.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 15.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR041201; PTPRJ_TM.
DR InterPro; IPR035992; Ricin_B-like_lectins.
DR InterPro; IPR000772; Ricin_B_lectin.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF2; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE BETA; 1.
DR Pfam; PF00041; fn3; 14.
DR Pfam; PF18861; PTP_tm; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 17.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 16.
DR SUPFAM; SSF50370; Ricin B-like lectins; 1.
DR PROSITE; PS50853; FN3; 9.
DR PROSITE; PS50231; RICIN_B_LECTIN; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}.
FT DOMAIN 330..423
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 509..596
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 597..686
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 687..773
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 948..1038
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1039..1129
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1212..1305
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1478..1574
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1575..1666
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1921..2181
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 2096..2172
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 2215 AA; 249064 MW; 6A56D59D3924DE1F CRC64;
MEAEFYMVIL TCLIFRNSEG FQIVHVQKQQ CLFKNEKVVV GSCNRTIQNQ QWMWTEDEKL
LHVKSALCLA ISNSSRGPSR SAILDLCSQA PRWTCYDQEG FLEVENASLF LQKQGSRVVV
KKARKYLHSW MKIDVNKEGK LVNESLCLKK AGLGAEVSVR STRNTAPPQI PTTFNAVPDS
LVFLIRNTTE AFIRNAAENY SQNSSERQHP NLHMTGITDT SWVLSTTQPF SRTTEETGLA
EPERCNFTLA ESKASSHSVS IQWRILGSPC NFSLIYSSDT LGAALCPIFR IDNTTYGCNL
QDLQAGTIYN FKIISLDEER TVVLQTDPLP PARFGVSKEK TTSTSLHVWW TPSSGKVTSY
EVQLFDENNQ KIQGVQIQES TSWNEYTFFN LTAGSKYNIA ITAVSGGKRS SSVYTNGSTV
PSPVKDIGIS TKANSLLISW SHGSGNVERY RLMLMDKGIL VHGGVVDKHA TSYAFHGLTP
GYLYNLTVMT EAAGLQNYRW KLVRTAPMEV SNLKVTNDGS LTSLKVKWQR PPGNVDSYNI
TLSHKGTIKE SRVLAPWITE THFKELVPGR LYQVTVSCVS GELSAQKMAV GRTFPDKVAN
LEANNNGRMR SLVVSWSPPA GDWEQYRILL FNDSVVLLNI AVGKEETQYV MNDTGFVPGR
QYEVEVIVES GNLKNSERCQ GRTVPLAVLQ LRVKHANETS LSIMWQAPVA EWEKYIISLA
DRDLLLIHKS LSKDAKEFTF TDLVPGRKYM ATVTSISGDL KNSSSVKGRT VPAQVTDLHV
ANQGMTSSLF TNWTQAQGDV EFYQVLLIHE NVVIKNESIS SEISRYSFHS LKSGSLYSVV
VTTVSGGISS RQVVVEGRTV PSSVSGVTVK NSGRNDYLSV SWLLAPGDVD NHEVTLSHDG
KVVQSLVIAK SVRECSFSSL TPGRLYTVTI TTRSGKYENH SFSQERTVPD KVQGVSVSNS
ARSDYLRVSW VHATGDFDHY EVTIKNKNNF IQTKSIPKSE NECVFAQLVP GRLYSVTVTT
KSGQYEASEQ GNGRTIPEPV KDLTLRNRST EDLHVTWSGA NGDVDQYEIQ LLFNDMKVFP
PFHLVNTATE YRFTSLTPGR QYKILVLTIS GDVQQSAFIE GFTVPSAVKN IHISPNGATD
SLTVNWTPGG GDVDSYTVSA FRHSQKVDSQ TIPKHVFEHT FHRLEAGEQY QIMIASVSGS
LKNQINVVGR TVPASVQGVI ADNAYSSHSL TVSWQKAAGV AERYDILLLT ENGILLRNTS
EPATTKQHKF EDLTPGKKYK IQILTVSGGL FSKEAQTEGR TVPAAVTDLR ITENSTRHLS
FRWTASEGEL SWYNIFLYNP DGNLQERAQV DPQVQSFSFQ NLLQGRMYKM VIVTHSGELS
NESFIFGRTV PASVSHLRGS NRNTTDSLWF NWSPASGDFD FYELILYNPN GTKKENWKDK
DLTEWRFQGL VPGRKYMLWV VTHSGDLSNK VTAESRTAPS PPSLMSFADI ANTSLAITWK
GPPDWTDYND FELQWLPRDA LTVFNPYNNR KSEGRIVYGL RPGRSYQFNV KTVSGDSWKT
YSKPIFGSVR TKPDKIQNLH CRPQNSTAIA CSWIPPDSDF DGYSIECRKM DTQEVEFSRK
LEKEKSLLNI MMLVPHKRYL VSIKVQSAGM TSEVVEDSTI TMIDRPPPPP PHIRVNEKDV
LISKSSINFT VNCSWFSDTN GAVKYFTVVV READGSDELK PEQQHPLPSY LEYRHNASIR
VYQTNYFASK CAENPNSNSK SFNIKLGAEM ESLGGKCDPT QQKFCDGPLK PHTAYRISIR
AFTQLFDEDL KEFTKPLYSD TFFSLPITTE SEPLFGAIEG VSAGLFLIGM LVAVVALLIC
RQKVSHGRER PSARLSIRRD RPLSVHLNLG QKGNRKTSCP IKINQFEGHF MKLQADSNYL
LSKEYEELKD VGRNQSCDIA LLPENRGKNR YNNILPYDAT RVKLSNVDDD PCSDYINASY
IPGNNFRREY IVTQGPLPGT KDDFWKMVWE QNVHNIVMVT QCVEKGRVKC DHYWPADQDS
LYYGDLILQM LSESVLPEWT IREFKICSEE QLDAHRLIRH FHYTVWPDHG VPETTQSLIQ
FVRTVRDYIN RSPGAGPTVV HCSAGVGRTG TFIALDRILQ QLDSKDSVDI YGAVHDLRLH
RVHMVQTECQ YVYLHQCVRD VLRARKLRSE QENPLFPIYE NVNPEYHRDP VYSRH
//