ID A0A2I2Y9A7_GORGO Unreviewed; 137 AA.
AC A0A2I2Y9A7;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Protein shisa-5 {ECO:0000256|ARBA:ARBA00040441};
DE AltName: Full=Scotin {ECO:0000256|ARBA:ARBA00041983};
GN Name=SHISA5 {ECO:0000313|Ensembl:ENSGGOP00000031496.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000031496.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000031496.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000031496.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000031496.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Can induce apoptosis in a caspase-dependent manner and plays
CC a role in p53/TP53-dependent apoptosis.
CC {ECO:0000256|ARBA:ARBA00037507}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the shisa family.
CC {ECO:0000256|ARBA:ARBA00038108}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CABD030021194; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030021195; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030021196; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030021197; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030021198; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030021199; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030021200; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018879018.1; XM_019023473.1.
DR Ensembl; ENSGGOT00000048455.1; ENSGGOP00000032657.1; ENSGGOG00000028207.2.
DR Ensembl; ENSGGOT00000065734.1; ENSGGOP00000031496.1; ENSGGOG00000028207.2.
DR GeneID; 101148514; -.
DR CTD; 51246; -.
DR GeneTree; ENSGT00390000008296; -.
DR Proteomes; UP000001519; Chromosome 3.
DR Bgee; ENSGGOG00000028207; Expressed in frontal cortex and 6 other cell types or tissues.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR InterPro; IPR026910; Shisa.
DR PANTHER; PTHR31395:SF14; PROTEIN SHISA-5; 1.
DR PANTHER; PTHR31395; SHISA; 1.
DR Pfam; PF13908; Shisa; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 137 AA; 14574 MW; 7DBAA96D341443AD CRC64;
MGFGATLAVG LTIFVLSVVT IIICFTCSCC CLYKTCRRPR PVVTTTTSTT VVHAPYPQPP
SVPPSYPGPS YQGYHTMPPQ PGMPAAPYPM QYPPPYPAQP MGPPAYHETL AEGAAAPYPA
SQPPYNPAYM DAPKAAL
//
