ID A0A2I2Y9U4_GORGO Unreviewed; 2537 AA.
AC A0A2I2Y9U4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Collagen type VI alpha 3 chain {ECO:0000313|Ensembl:ENSGGOP00000031681.1};
GN Name=COL6A3 {ECO:0000313|Ensembl:ENSGGOP00000031681.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000031681.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000031681.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000031681.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000031681.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030019316; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSGGOT00000064778.1; ENSGGOP00000031681.1; ENSGGOG00000002468.3.
DR GeneTree; ENSGT00940000156462; -.
DR Proteomes; UP000001519; Chromosome 2B.
DR Bgee; ENSGGOG00000002468; Expressed in heart and 5 other cell types or tissues.
DR GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR GO; GO:0005788; C:endoplasmic reticulum lumen; IEA:UniProt.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:InterPro.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 1.
DR CDD; cd22629; Kunitz_collagen_alpha3_VI; 1.
DR CDD; cd01481; vWA_collagen_alpha3-VI-like; 3.
DR CDD; cd01450; vWFA_subfamily_ECM; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 4.10.410.10; Pancreatic trypsin inhibitor Kunitz domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 9.
DR InterPro; IPR008160; Collagen.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002223; Kunitz_BPTI.
DR InterPro; IPR036880; Kunitz_BPTI_sf.
DR InterPro; IPR020901; Prtase_inh_Kunz-CS.
DR InterPro; IPR041900; vWA_collagen_alpha3-VI-like.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24020:SF13; COLLAGEN ALPHA-3(VI) CHAIN; 1.
DR Pfam; PF01391; Collagen; 3.
DR Pfam; PF00014; Kunitz_BPTI; 1.
DR Pfam; PF00092; VWA; 9.
DR PRINTS; PR00759; BASICPTASE.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00131; KU; 1.
DR SMART; SM00327; VWA; 9.
DR SUPFAM; SSF57362; BPTI-like; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF53300; vWA-like; 9.
DR PROSITE; PS00280; BPTI_KUNITZ_1; 1.
DR PROSITE; PS50279; BPTI_KUNITZ_2; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50234; VWFA; 9.
PE 4: Predicted;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Collagen {ECO:0000256|ARBA:ARBA00023119};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 33..208
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 225..397
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 417..593
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 621..792
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 824..997
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1027..1200
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1226..1412
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1761..1940
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 1978..2174
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 2351..2445
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 2472..2522
FT /note="BPTI/Kunitz inhibitor"
FT /evidence="ECO:0000259|PROSITE:PS50279"
FT REGION 1000..1022
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1429..1734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2218..2247
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2317..2346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2433..2453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1496..1512
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1520..1540
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1663..1683
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2537 AA; 274634 MW; C939CF744888EFEE CRC64;
TGVCPHARLI FVFLVVMGFP LVGQAVIEVN KRDIVFLVDG SSALGLANFN AIRDFIAKVI
QRLEIGQDLI QVAVAQYADT VRPEFYFNTH PTKREVITAV RKMKPLDGSA LYTGSALDFV
RNNLFTSSAG YRAAEGIPKL LVLITGGKSL DEISQPAQEL KRSSIMAFAI GNKGADQAEL
EEIAFDSSLV FIPAEFRAAP LQGMLPGLLA PLRTLSGTPE ESKRDILFLF DGSANLVGQF
PVVRDFLYKI IDELDVKPDG TRIAVAQYSD DVKVESRFDE HQSKPEILNL VKRMKIKTGK
ALNLGYALDY AQRYIFVKSA GSRIEDGVLQ FLVLLVAGRS SDRVDGPASN LKQSGVVPFI
FQAKNADPAE LEQIVLSPAF ILAAESLPKI GDLQPQIVNL LKSVHNGAPA PVSGEKDVVF
LLDGSEGVRS GFPLLKEFVQ RVVESLDVGQ DRVRVAVVQY SDRTRPEFYL NSYMNQQDVV
NAVRQLTLLG GPTPNTGAAL EFVLRNILVS SAGSRITEGV PQLLIVLTAD RSGDDVRNPS
VVVKRGGAVP IGIGIGNADI TEMQTISFIP DFAVAIPTFR QLGTVQQVIS ERVTQLTRKE
LSRLQPVLQP LPSPGVGGKR DVVFLIDGSQ SAGPEFQYIR TLIERLVDYL DVGFDTTRVA
VIQFSDDPKV EFLLNAHSSK DEVQNAVQRL RPKGGRQINV GSALEYVSRN IFKRPLGSRI
EEGVPQFLVL ILSGKSDDEV DDPAVELKQF GVAPFTIARN ADQEELVKIS LSPEYVFSVS
TFRELPSLEQ KLLTPITTLT SEQIQKLLAS TRYPPPAVES DAADIVFLID SSEGVRPDGF
AHIRDFVSRI VRRLNIGPSK VRVGVVQFSN DVFPEFYLKT YRSQAPVLDA IRRLRLRGGS
PLNTGKALEF VARNLFVKSA GSRIEDGVPQ HLVLVLGGKS QDDVSRFAQV IRSSGIVSLG
VGDRNIDRTE LQTITNDPRL VFTVREFREL PNIEERIMNS FGPSAATPAP PGVDTPPPSR
PEKKKADIVF LLDGSINFRR DSFQEVLRFV SEIVDTVYED GDSIQVGLVQ YNSDPTDEFF
LKDFSTKRQI IDAINKVVYK GGRHANTKVG LEHLRVNHFV PEAGSRLDQR VPQIAFVITG
GKSVEDAQDV SLALTQRGVK VFAVGVRNID SEEVGKIASN SATAFRVGNV QELSELSEQV
LETLHDAMHE TLCPGVTDAA KACNLDVILG FDGSRDQNVF VAQKGFESKV DAILNRISQM
HRVSCSGGRS PTVRVSVVAN TPSGPVEAFD FDEYQPEMLE KFRNMRSQHP YVLTEDTLKV
YLNKFRQSSP DSVKVVIHFT DGADGDLADL HRASENLRQE GVRALILVGL ERVANLERLM
HVEFGRGFMY DRPLRLNLLD LDYELAEQLD NIAEKACCGV PCKCSGQRGD RGPIGSIGPK
GIPGEDGYRG YPGDEGGPGE RGPPGVNGTQ GFQGCPGQRG VKGSRGFPGE KGEVGEIGLD
GLDGEDGDKG LPGSSGEKGN PGRRGDKGPR GEKGERGDVG IRGDPGNPGQ DSQERGPKGE
TGDLGPMGVP GRDGVPGGPG ETGKNVSAIR ALGGSGNKGG PGQPGFEGEQ GTRGAQGPAG
PAGPPGLIGE QGISGPRVSL GHIAKQAEKP GPKGGIGNRG PRGETGDDGR DGVGSEGRRG
KKGNPGEPGL NGTTGPKGIR GRRGNSGPPG IVGQKGDPGY PGPAGPKGNR GDSIDVSSIL
SLTLRPPLST GPLECPVFPT ELAFALDTSE GVNQDTFGRM RDVVLSIVND LTIAESNCPR
GARVAVVTYN NEVTTEIRFA DSKRKSVLLD KIKNLQVALT SKQQSLETAM SFVARNTFKR
VRNGFLMRKV AVFFSNTPTR ASPQLREAVL KLSDAGITPL FLTRQEDRQL INALQINNTA
VGHALVLPAG RDLTDFLENV LTCHVCLDIC NIDPSCGFGS WRPSFRDRRA AGSDVDIDMA
FILDSAETTT LFQFNEMKKY VAYLVRQLDM SPDPKASQHF ARVAVVQHAP SESVDNASMP
PVKVEFSLTD YGSKEKLVDF LSRGMTQLQG TRALGSAIEY TIENVFESAP NPRDLKIVVL
MLTGEVPEQQ LEEAQRVILQ AKCKGYFFVV LGIGRKVNIK EVYTFASEPN DVFFKLVDKS
TELNEEPLMR FGRLLPSFVS SENAFYLSPD IRKQCDWFQG DQPTKNLVKF GHKQVNVPNN
VTSSPTSNPV TTTKPVTTTK PVTTTTKPVT TTTKPVIIVN QASVKPPAPV KPAPAKPVAA
KPVATKTATV RPPVAVKPAT AAKPVAAKPA AVRPPAAAAA KPVATKPEVP RPQAAKPAAT
KPATTKPVVK MSREVQVFEI TENSAKLHWE RPEPPGPYFY DLTVTSAHDQ SLVLKQNLTV
TDRVIGGLLA GQTYHVAVVC YLRSQVRATY HGSFSTKKSQ PPPPQPARSA SSSTINLMVS
TEPLALTETD ICKLPKDEGT CRDFILKWYY DPNTKSCARF WYGGCGGNEN KFGSQKECEK
VCAPVLAKPG VISVMGT
//
