ID A0A2I2YAC5_GORGO Unreviewed; 4913 AA.
AC A0A2I2YAC5;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Ryanodine receptor 1 {ECO:0000256|ARBA:ARBA00014291};
DE AltName: Full=Skeletal muscle calcium release channel {ECO:0000256|ARBA:ARBA00032969};
DE AltName: Full=Skeletal muscle ryanodine receptor {ECO:0000256|ARBA:ARBA00031197};
DE AltName: Full=Skeletal muscle-type ryanodine receptor {ECO:0000256|ARBA:ARBA00033030};
DE AltName: Full=Type 1 ryanodine receptor {ECO:0000256|ARBA:ARBA00032832};
GN Name=RYR1 {ECO:0000313|Ensembl:ENSGGOP00000031856.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000031856.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000031856.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000031856.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000031856.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) = Ca(2+)(out); Xref=Rhea:RHEA:29671,
CC ChEBI:CHEBI:29108; Evidence={ECO:0000256|ARBA:ARBA00036634};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Sarcoplasmic
CC reticulum membrane {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004326}.
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DR EMBL; CABD030113423; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030113424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030113425; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030113426; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030113427; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030113428; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030113429; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030113430; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030113431; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030113432; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSGGOT00000059360.1; ENSGGOP00000031856.1; ENSGGOG00000015461.3.
DR GeneTree; ENSGT00940000155288; -.
DR Proteomes; UP000001519; Chromosome 19.
DR Bgee; ENSGGOG00000015461; Expressed in prefrontal cortex and 2 other cell types or tissues.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:InterPro.
DR CDD; cd12877; SPRY1_RyR; 1.
DR CDD; cd12878; SPRY2_RyR; 1.
DR CDD; cd12879; SPRY3_RyR; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.490.160; -; 2.
DR Gene3D; 2.60.120.920; -; 3.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 6.20.350.10; -; 1.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR013333; Ryan_recept.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR003032; Ryanodine_rcpt.
DR InterPro; IPR009460; Ryanrecept_TM4-6.
DR InterPro; IPR048581; RYDR_Jsol.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR InterPro; IPR035761; SPRY1_RyR.
DR InterPro; IPR035764; SPRY2_RyR.
DR InterPro; IPR035762; SPRY3_RyR.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46399:SF10; RYANODINE RECEPTOR 1; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF06459; RR_TM4-6; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR Pfam; PF21119; RYDR_Jsol; 1.
DR Pfam; PF02026; RyR; 4.
DR Pfam; PF00622; SPRY; 3.
DR PRINTS; PR00795; RYANODINER.
DR SMART; SM00472; MIR; 4.
DR SMART; SM00449; SPRY; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 1.
DR SUPFAM; SSF82109; MIR domain; 2.
DR PROSITE; PS50188; B302_SPRY; 3.
DR PROSITE; PS50919; MIR; 4.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW S-nitrosylation {ECO:0000256|ARBA:ARBA00022799};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 4436..4456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4713..4735
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4794..4817
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 93..148
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 155..200
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 206..260
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 266..323
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 577..793
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1009..1204
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1352..1566
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REGION 1303..1381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1863..1919
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2387..2409
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2824..2854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3473..3494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4234..4354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4366..4413
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4464..4496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1366..1381
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1866..1915
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2824..2839
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4245..4266
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4369..4394
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4395..4409
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4913 AA; 552635 MW; 1A21DA850D48EB48 CRC64;
SGDSPGSDSR VDDEVVLQCS ATVLKEQLKL CLAAEGFGNR LCFLEPTSNA QNVPPDLAIC
CFVLEQSLSV RALQEMLANT VEAGVESSQG GGHRTLLYGH AILLRHAHSR MYLSCLTTSR
SMTDKLAFDV GLQEDATGEA CWWTMHPASK QRSEGEKVRV GDDIILVSVS SERYLHLSTA
SGELQVDASF MQTLWNMNPI CSRCEEGFVT GGHVLRLFHG HMDECLTISP ADSDDQRRLV
YYEGGAVCTH ARSLWRLEPL RISWSGSHLR WGQPLRVRHV TTGRYLALTE DQGLVVVDAS
KAHTKATSFC FRISKEKLDV APKRDVEGMG PPEIKYGESL CFVQHVASGL WLTYAAPDPK
ALRLGVLKKK AMLHQEGHMD DALSLTRCQQ EESQAARMIH STNGLYNQFI KSLDSFSGKP
RGSGPPAGTA LPIEGVILSL QDLIIYFEPP SEDLQHEEKQ SKLRSLRNRQ SLFQEEGMLS
MVLNCIDRLN VYTTAAHFAE FAGEEAAESW KEIVNLLYEL LASLIRGNRS NCALFSTNLD
WLVSKLDRLE ASSGILEVLY CVLIESPEVL NIIQENHIKS IISLLDKHGR NHKVLDVLCS
LCVCNGVAVR SNQDLITENL LPGRELLLQT NLINYVTSIR PNIFVGRAEG TTQYSKWYFE
VMVDEVTPFL TAQATHLRVG WALTEGYSPY PGGGEGWGGN GVGDDLYSYG FDGLHLWTGH
VARPVTSPGQ HLLAPEDVIS CCLDLSVPSI SFRINGCPVQ GVFESFNLDG LFFPVVSFSA
GVKVRFLLGG RHGEFKFLPP PGYAPCHEAV LPRERLHLEP IKEYRREGPR GPHLVGPSRC
LSHTDFVPCP VDTVQIVLPP HLERIREKLA ENIHELWALT RIEQGWTYGP VRDDNKRLHP
CLVDFHSLPE PERNYNLQMS GETLKTLLAL GCHVGMADEK AEDNLKKTKL PKTYMMSNGY
KPAPLDLSHV RLTPAQTTLV DRLAENGHNV WARDRVGQGW SYSAVQDIPA RRNPRLVPYR
LLDEATKRSN RDSLCQAVRT LLGYGYNIEP PDQEPSQVEN QSRCDRVRIF RAEKSYTVQS
GRWYFEFEAV TTGEMRVGWA RPELRPDVEL GADELAYVFN GHRGQRWHLG SEPFGRPWQP
GDVVGCMIDL TENTIIFTLN GEVLMSDSGS ETAFREIEIG DGFLPVCSLG PGQVGHLNLG
QDVSSLRFFA ICGLQEGFEP FAINMQRPVT TWFSKGLPQF EPVPLEHPHY EVSRVDGTVD
TPPCLRLTHR TWGSQNSLVE MLFLRLSLPV QFHQHFRCTA GATPLAPPGL QPPAEDEARA
AEPDPDYENL RRSAGGWGEA ENGKEGTAKE GAPGGTPQAG GEAQPARAEN EKDATTEKNK
KRGFLFKAKK VAMMTQPPAT PTLPRLPHDV VPADNRDDPE IILNTTTYYY SVRVFAGQEP
SCVWAGWVTP DYHQHDMSFD LSKVRVVTVT MGDEQGNVHS SLKCSNCYMV WGGDFVSPGQ
QGRISHTDLV IGCLVDLATG LMTFTANGKE SNTFFQVEPN TKLFPAVFVL PTHQNVIQFE
LGKQKNIMPL SAAMFQSERK NPAPQCPPRL EMQMLMPVSW SRMPNHFLQV ETRRAGERLG
WAVQCQEPLT MMALHIPEEN RCMDILELSE RLDLQRFHSH TLCLYRAVCA LGNNRVAHAL
CSHVDQAQLL HALEDAHLPG PLRAGYYDLL ISIHLESACR SRRSMLSEYI VPLTPETRAI
TLFPPGRSTE NGHPRHGLPG VGVTTSLRPP HHFSPPCFVA ALPAAGAAEA PARLSPAIPL
EALRDKALRM LGEAVRDGGQ HARDPVGGSV EFQFVPVLKL VSTLLVMGIF GDEDVKQILK
MIEPEVFTEE EEEEEEEEED EEEDEEEKEE DEEETAQEKE DEEKEEEEAA EGEKEEGLEE
GLLQMKLPES VKLQMCHLLE YFCDQELQHR VESLAAFAER YVDKLQANQR SRYGLLIKAF
SMTAAETARR TREFRSPPQE QINMLLQFKD GTDEEDCPLP EEIRQDLLDF HQDLLAHCGI
QLDGEEEEPE EETTLGSRLM SLLEKVRLVK KKEEKPEEER SAEESKPRSL QELVSHMVVR
WAQEDFVQSP ELVRAMFSLL HRQYDGLGEL LRALPRAYTI SPSSVEDTMS LLECLGQIRS
LLIVQMGPQE ENLMIQSIGN IMNNKVFYQH PNLMRALGMH ETVMEVMVNV LGGGESKEIR
FPKMVTSCCR FLCYFCRISR QNQRSMFDHL SYLLENSGIG LGMQGSTPLD VAAASVIDNN
ELALALQEQD LEKVVSYLAG CGLQSCPMLV AKGYPDIGWN PCGGERYLDF LRFAVFVNGE
SVEENANVVV RLLIRKPECF GPALRGEGGS GLLAAIEEAI RISEDPARDG PGIRRDRRRE
HFGEEPPEEN RVHLGHAVMS FYAALIDLLG RCAPEMHLIQ AGKGEALRIR AILRSLVPLE
DLVGIISLPL QIPTLGKDGA LVQPKMSASF VPDHKASMVL FLDRVYGIEN QDFLLHVLDV
GFLPDMRAAA SLDTATFSTT EMALALNRYL CLAVLPLITK CAPLFAGTEH RAIMVDSMLH
TVYRLSRGRS LTKAQRDVIE DCLMSLCRYI RPSMLQHLLR RLVFDVPILN EFAKMPLKLL
TNHYERCWKY YCLPTGWANF GVTSEEELHL TRKLFWGIFD SLAHKKYDPE LYRMAMPCLC
AIAGALPPDY VDASYSSKAE KKATVDAEGN FDPRPVETLN VIIPEKLDSF INKFAEYTHE
KWAFDKIQNN WSYGENIDEE LKTHPMLRPY KTFSEKDKEI YRWPIKESLK AMIAWEWTIE
KAREGEEEKT EKKKTRKISQ SAQTYDPREG YNPQPPDLSA VTLSRELQAM AEQLAENYHN
TWGRKKKQEL EAKGGGTHPL LVPYDTLTAK EKARDREKAQ ELLKFLQMNG YAVTRGLKDM
ELDSSSIEKR FAFGFLQQLL RWMDISQEFI AHLEAVVSSG RVEKSPHEQE IKFFAKILLP
LINQYFTNHC LYFLSTPAKV LGSGGHASNK EKEMITSLFC KLAALVRHRV SLFGTDASAV
VNCLHILARS LDARTVMKSG PEIVKAGLRS FFESASEDIE KMVENLRLGK VSQARTQVKG
VGQNLTYTTV ALLPVLTTLF QHIAQHQFGD DVILDDVQVS CYRTLCSIYS LGTTKNTYVE
KLRPALGECL ARLAAAMPVA FLEPQLNEYN ACSVYTTKSP RERAILGLPN SVEEMCPDIP
VLERLMADIG GLAESGARYT EMPHVIEITL PMLCSYLPRW WERGPEAPPP ALPAGAPPPC
TAVTSDHLNS LLGNILRIIV NNLGIDEASW MKRLAVFAQP IVSRARPELL QSHFIPTIGR
LRKRAGKVVS EEEQLRLEAK AEAQEGELLV RDEFSVLCRD LYALYPLLIR YVDNNRAQWL
TEPNPSAEEL FRMVGEIFIY WSKSHNFKRE EQNFVVQNEI NNMSFLTADN KSKMAKVGSG
GSDQERTKKK RRGDRYSVQT SLIVATLKKM LPIGLNMCAP TDQDLITLAK TRYALVPVEG
SPSLRWQMAL YRGVPGREED ADDPEKIVRR VQEVSAVLYY LDQTEHPYKS KKAVWHKLLS
KQRRRAVVAC FRMTRMGGRE ARRRAHRACN MFLESYKAAW IVTEDHSFED RMIDDLSKAG
EQEEEEEEVE EKKPDPLHQL VLHFSRTALT EKSKLDEDYL YMAYADIMAK SCHLEEGGEN
GEAEEEVEVS FEEKEMEKQR LLYQQARLHT RGAAEMVLQM ISACKGETGA MVSSTLKLGI
SILNGGNAEV QQKMLDYLKD KKEVGFFQSI QALMQTCSVL DLNAFERQNK AEGLGMVNED
GTVINRQNGN SPREKVMADD EFTQDLFRFL QLLCEGHNND FQNYLRTQTG NTTTINIIIC
TVDYLLRLQE SISDFYWYYS GKDVIEEQGK RNFSKAMSVA KQVFNSLTEY IQGPCTGNQQ
SLAHSRLWDA VVGFLHVFAH MMMKLAQDSS QIELLKELLD LQKDMVVMLL SLLEGNVVNG
MIARQMVDML VESSSNVEMI LKFFDMFLKL KDIVGSEAFQ DYVTDPRGLI SKKDFQKAMD
SQKQFSGPEI QFLLSCSEAD ENEMINCEEF ANRFQEPARD IGFNVAVLLT NLSEHVPHDP
RLHNFLELAE SILEYFRPYL GRIEIMGASR RIERIYFEIS ETNRAQWEMP QVKESKRQFI
FDVVNEGGEA EKMELFVSFC EDTIFEMQIA AQISEPEGEP ETDEDEGAGA AKTRPKKPRR
NPPSGDEVHG EQPAGPGGDA DGEGASEGAG EAAEGAGDEE EAVHEAGPGG ADGAVAVTDG
GPFRPEGAGG LGDMGDTTPA EPPTPEGSPI LKRKLGVREQ AGFWGFGKMG DWREEESPAG
AENGEKEEVP EPPPEPPKKQ APPSPPPKKE EAGGEFWGEL EVQRVKFLNY LSRNFYTLRF
LALFLAFAIN FILLFYKVSD SPPGEDDMEG SAAGDVSGAG SGGGSGWGLG AGEEAEGDED
ENMVYYFLEE STGYMEPALR CLSLLHTLVA FLCIIGYNCL KVPLVIFKRE KELARKLEFD
GLYITEQPED DDVKGQWDRL VLNTPSFPSN YWDKFVKRKV LDKHGDIYGR ERIAELLGMD
LATLEITAHN ERKPNPPPGL LTWLMSIDVK YQIWKFGVIF TDNSFLYLGW YMVMSLLGHY
NNFFFAAHLL DIAMGVKTLR TILSSVTHNG KQLVMTVGLL AVVVYLYTVV AFNFFRKFYN
KSEDEDEPDM KCDDMMTCYL FHMYVGVRAG GGIGDEIEDP AGDEYELYRV VFDITFFFFV
IVILLAIIQG LIIDAFGELR DQQEQVKEDM ETKCFICGIG SDYFDTTPHG FETHTLEEHN
LANYMFFLMY LINKDETEHT GQESYVWKMY QERCWDFFPA GDCFRKQYED QLS
//
