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Database: UniProt
Entry: A0A2I2YAC5_GORGO
LinkDB: A0A2I2YAC5_GORGO
Original site: A0A2I2YAC5_GORGO 
ID   A0A2I2YAC5_GORGO        Unreviewed;      4913 AA.
AC   A0A2I2YAC5;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   05-DEC-2018, entry version 5.
DE   SubName: Full=Ryanodine receptor 1 {ECO:0000313|Ensembl:ENSGGOP00000031856};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000031856, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000031856, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000031856}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2018) to UniProtKB.
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DR   EMBL; CABD030113423; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030113424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030113425; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030113426; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030113427; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030113428; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030113429; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030113430; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030113431; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030113432; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSGGOT00000059360; ENSGGOP00000031856; ENSGGOG00000015461.
DR   GeneTree; ENSGT00940000155288; -.
DR   Proteomes; UP000001519; Chromosome 19.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR033215; RyR1.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 2.
DR   PANTHER; PTHR13715:SF15; PTHR13715:SF15; 2.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4436   4456       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4713   4735       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4794   4817       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       93    148       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      155    200       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      206    260       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      266    323       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      331    388       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      577    793       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1009   1204       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1352   1566       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     1865   1920       {ECO:0000256|SAM:Coils}.
FT   COILED     2909   2929       {ECO:0000256|SAM:Coils}.
FT   COILED     3653   3673       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4913 AA;  552635 MW;  1A21DA850D48EB48 CRC64;
     SGDSPGSDSR VDDEVVLQCS ATVLKEQLKL CLAAEGFGNR LCFLEPTSNA QNVPPDLAIC
     CFVLEQSLSV RALQEMLANT VEAGVESSQG GGHRTLLYGH AILLRHAHSR MYLSCLTTSR
     SMTDKLAFDV GLQEDATGEA CWWTMHPASK QRSEGEKVRV GDDIILVSVS SERYLHLSTA
     SGELQVDASF MQTLWNMNPI CSRCEEGFVT GGHVLRLFHG HMDECLTISP ADSDDQRRLV
     YYEGGAVCTH ARSLWRLEPL RISWSGSHLR WGQPLRVRHV TTGRYLALTE DQGLVVVDAS
     KAHTKATSFC FRISKEKLDV APKRDVEGMG PPEIKYGESL CFVQHVASGL WLTYAAPDPK
     ALRLGVLKKK AMLHQEGHMD DALSLTRCQQ EESQAARMIH STNGLYNQFI KSLDSFSGKP
     RGSGPPAGTA LPIEGVILSL QDLIIYFEPP SEDLQHEEKQ SKLRSLRNRQ SLFQEEGMLS
     MVLNCIDRLN VYTTAAHFAE FAGEEAAESW KEIVNLLYEL LASLIRGNRS NCALFSTNLD
     WLVSKLDRLE ASSGILEVLY CVLIESPEVL NIIQENHIKS IISLLDKHGR NHKVLDVLCS
     LCVCNGVAVR SNQDLITENL LPGRELLLQT NLINYVTSIR PNIFVGRAEG TTQYSKWYFE
     VMVDEVTPFL TAQATHLRVG WALTEGYSPY PGGGEGWGGN GVGDDLYSYG FDGLHLWTGH
     VARPVTSPGQ HLLAPEDVIS CCLDLSVPSI SFRINGCPVQ GVFESFNLDG LFFPVVSFSA
     GVKVRFLLGG RHGEFKFLPP PGYAPCHEAV LPRERLHLEP IKEYRREGPR GPHLVGPSRC
     LSHTDFVPCP VDTVQIVLPP HLERIREKLA ENIHELWALT RIEQGWTYGP VRDDNKRLHP
     CLVDFHSLPE PERNYNLQMS GETLKTLLAL GCHVGMADEK AEDNLKKTKL PKTYMMSNGY
     KPAPLDLSHV RLTPAQTTLV DRLAENGHNV WARDRVGQGW SYSAVQDIPA RRNPRLVPYR
     LLDEATKRSN RDSLCQAVRT LLGYGYNIEP PDQEPSQVEN QSRCDRVRIF RAEKSYTVQS
     GRWYFEFEAV TTGEMRVGWA RPELRPDVEL GADELAYVFN GHRGQRWHLG SEPFGRPWQP
     GDVVGCMIDL TENTIIFTLN GEVLMSDSGS ETAFREIEIG DGFLPVCSLG PGQVGHLNLG
     QDVSSLRFFA ICGLQEGFEP FAINMQRPVT TWFSKGLPQF EPVPLEHPHY EVSRVDGTVD
     TPPCLRLTHR TWGSQNSLVE MLFLRLSLPV QFHQHFRCTA GATPLAPPGL QPPAEDEARA
     AEPDPDYENL RRSAGGWGEA ENGKEGTAKE GAPGGTPQAG GEAQPARAEN EKDATTEKNK
     KRGFLFKAKK VAMMTQPPAT PTLPRLPHDV VPADNRDDPE IILNTTTYYY SVRVFAGQEP
     SCVWAGWVTP DYHQHDMSFD LSKVRVVTVT MGDEQGNVHS SLKCSNCYMV WGGDFVSPGQ
     QGRISHTDLV IGCLVDLATG LMTFTANGKE SNTFFQVEPN TKLFPAVFVL PTHQNVIQFE
     LGKQKNIMPL SAAMFQSERK NPAPQCPPRL EMQMLMPVSW SRMPNHFLQV ETRRAGERLG
     WAVQCQEPLT MMALHIPEEN RCMDILELSE RLDLQRFHSH TLCLYRAVCA LGNNRVAHAL
     CSHVDQAQLL HALEDAHLPG PLRAGYYDLL ISIHLESACR SRRSMLSEYI VPLTPETRAI
     TLFPPGRSTE NGHPRHGLPG VGVTTSLRPP HHFSPPCFVA ALPAAGAAEA PARLSPAIPL
     EALRDKALRM LGEAVRDGGQ HARDPVGGSV EFQFVPVLKL VSTLLVMGIF GDEDVKQILK
     MIEPEVFTEE EEEEEEEEED EEEDEEEKEE DEEETAQEKE DEEKEEEEAA EGEKEEGLEE
     GLLQMKLPES VKLQMCHLLE YFCDQELQHR VESLAAFAER YVDKLQANQR SRYGLLIKAF
     SMTAAETARR TREFRSPPQE QINMLLQFKD GTDEEDCPLP EEIRQDLLDF HQDLLAHCGI
     QLDGEEEEPE EETTLGSRLM SLLEKVRLVK KKEEKPEEER SAEESKPRSL QELVSHMVVR
     WAQEDFVQSP ELVRAMFSLL HRQYDGLGEL LRALPRAYTI SPSSVEDTMS LLECLGQIRS
     LLIVQMGPQE ENLMIQSIGN IMNNKVFYQH PNLMRALGMH ETVMEVMVNV LGGGESKEIR
     FPKMVTSCCR FLCYFCRISR QNQRSMFDHL SYLLENSGIG LGMQGSTPLD VAAASVIDNN
     ELALALQEQD LEKVVSYLAG CGLQSCPMLV AKGYPDIGWN PCGGERYLDF LRFAVFVNGE
     SVEENANVVV RLLIRKPECF GPALRGEGGS GLLAAIEEAI RISEDPARDG PGIRRDRRRE
     HFGEEPPEEN RVHLGHAVMS FYAALIDLLG RCAPEMHLIQ AGKGEALRIR AILRSLVPLE
     DLVGIISLPL QIPTLGKDGA LVQPKMSASF VPDHKASMVL FLDRVYGIEN QDFLLHVLDV
     GFLPDMRAAA SLDTATFSTT EMALALNRYL CLAVLPLITK CAPLFAGTEH RAIMVDSMLH
     TVYRLSRGRS LTKAQRDVIE DCLMSLCRYI RPSMLQHLLR RLVFDVPILN EFAKMPLKLL
     TNHYERCWKY YCLPTGWANF GVTSEEELHL TRKLFWGIFD SLAHKKYDPE LYRMAMPCLC
     AIAGALPPDY VDASYSSKAE KKATVDAEGN FDPRPVETLN VIIPEKLDSF INKFAEYTHE
     KWAFDKIQNN WSYGENIDEE LKTHPMLRPY KTFSEKDKEI YRWPIKESLK AMIAWEWTIE
     KAREGEEEKT EKKKTRKISQ SAQTYDPREG YNPQPPDLSA VTLSRELQAM AEQLAENYHN
     TWGRKKKQEL EAKGGGTHPL LVPYDTLTAK EKARDREKAQ ELLKFLQMNG YAVTRGLKDM
     ELDSSSIEKR FAFGFLQQLL RWMDISQEFI AHLEAVVSSG RVEKSPHEQE IKFFAKILLP
     LINQYFTNHC LYFLSTPAKV LGSGGHASNK EKEMITSLFC KLAALVRHRV SLFGTDASAV
     VNCLHILARS LDARTVMKSG PEIVKAGLRS FFESASEDIE KMVENLRLGK VSQARTQVKG
     VGQNLTYTTV ALLPVLTTLF QHIAQHQFGD DVILDDVQVS CYRTLCSIYS LGTTKNTYVE
     KLRPALGECL ARLAAAMPVA FLEPQLNEYN ACSVYTTKSP RERAILGLPN SVEEMCPDIP
     VLERLMADIG GLAESGARYT EMPHVIEITL PMLCSYLPRW WERGPEAPPP ALPAGAPPPC
     TAVTSDHLNS LLGNILRIIV NNLGIDEASW MKRLAVFAQP IVSRARPELL QSHFIPTIGR
     LRKRAGKVVS EEEQLRLEAK AEAQEGELLV RDEFSVLCRD LYALYPLLIR YVDNNRAQWL
     TEPNPSAEEL FRMVGEIFIY WSKSHNFKRE EQNFVVQNEI NNMSFLTADN KSKMAKVGSG
     GSDQERTKKK RRGDRYSVQT SLIVATLKKM LPIGLNMCAP TDQDLITLAK TRYALVPVEG
     SPSLRWQMAL YRGVPGREED ADDPEKIVRR VQEVSAVLYY LDQTEHPYKS KKAVWHKLLS
     KQRRRAVVAC FRMTRMGGRE ARRRAHRACN MFLESYKAAW IVTEDHSFED RMIDDLSKAG
     EQEEEEEEVE EKKPDPLHQL VLHFSRTALT EKSKLDEDYL YMAYADIMAK SCHLEEGGEN
     GEAEEEVEVS FEEKEMEKQR LLYQQARLHT RGAAEMVLQM ISACKGETGA MVSSTLKLGI
     SILNGGNAEV QQKMLDYLKD KKEVGFFQSI QALMQTCSVL DLNAFERQNK AEGLGMVNED
     GTVINRQNGN SPREKVMADD EFTQDLFRFL QLLCEGHNND FQNYLRTQTG NTTTINIIIC
     TVDYLLRLQE SISDFYWYYS GKDVIEEQGK RNFSKAMSVA KQVFNSLTEY IQGPCTGNQQ
     SLAHSRLWDA VVGFLHVFAH MMMKLAQDSS QIELLKELLD LQKDMVVMLL SLLEGNVVNG
     MIARQMVDML VESSSNVEMI LKFFDMFLKL KDIVGSEAFQ DYVTDPRGLI SKKDFQKAMD
     SQKQFSGPEI QFLLSCSEAD ENEMINCEEF ANRFQEPARD IGFNVAVLLT NLSEHVPHDP
     RLHNFLELAE SILEYFRPYL GRIEIMGASR RIERIYFEIS ETNRAQWEMP QVKESKRQFI
     FDVVNEGGEA EKMELFVSFC EDTIFEMQIA AQISEPEGEP ETDEDEGAGA AKTRPKKPRR
     NPPSGDEVHG EQPAGPGGDA DGEGASEGAG EAAEGAGDEE EAVHEAGPGG ADGAVAVTDG
     GPFRPEGAGG LGDMGDTTPA EPPTPEGSPI LKRKLGVREQ AGFWGFGKMG DWREEESPAG
     AENGEKEEVP EPPPEPPKKQ APPSPPPKKE EAGGEFWGEL EVQRVKFLNY LSRNFYTLRF
     LALFLAFAIN FILLFYKVSD SPPGEDDMEG SAAGDVSGAG SGGGSGWGLG AGEEAEGDED
     ENMVYYFLEE STGYMEPALR CLSLLHTLVA FLCIIGYNCL KVPLVIFKRE KELARKLEFD
     GLYITEQPED DDVKGQWDRL VLNTPSFPSN YWDKFVKRKV LDKHGDIYGR ERIAELLGMD
     LATLEITAHN ERKPNPPPGL LTWLMSIDVK YQIWKFGVIF TDNSFLYLGW YMVMSLLGHY
     NNFFFAAHLL DIAMGVKTLR TILSSVTHNG KQLVMTVGLL AVVVYLYTVV AFNFFRKFYN
     KSEDEDEPDM KCDDMMTCYL FHMYVGVRAG GGIGDEIEDP AGDEYELYRV VFDITFFFFV
     IVILLAIIQG LIIDAFGELR DQQEQVKEDM ETKCFICGIG SDYFDTTPHG FETHTLEEHN
     LANYMFFLMY LINKDETEHT GQESYVWKMY QERCWDFFPA GDCFRKQYED QLS
//
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