ID A0A2I2YAL6_GORGO Unreviewed; 1074 AA.
AC A0A2I2YAL6;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Zinc finger protein 518B {ECO:0000313|Ensembl:ENSGGOP00000031954.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000031954.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000031954.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000031954.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000031954.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030027148; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_004038487.1; XM_004038439.2.
DR RefSeq; XP_018881425.1; XM_019025880.1.
DR RefSeq; XP_018881426.1; XM_019025881.1.
DR AlphaFoldDB; A0A2I2YAL6; -.
DR STRING; 9593.ENSGGOP00000031954; -.
DR Ensembl; ENSGGOT00000044418.1; ENSGGOP00000031954.1; ENSGGOG00000040283.1.
DR GeneTree; ENSGT00940000160595; -.
DR InParanoid; A0A2I2YAL6; -.
DR OMA; CEYGAVR; -.
DR OrthoDB; 4069741at2759; -.
DR Proteomes; UP000001519; Chromosome 4.
DR Bgee; ENSGGOG00000040283; Expressed in testis and 6 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR23234:SF10; GENE 10130-RELATED; 1.
DR PANTHER; PTHR23234; ZNF44 PROTEIN; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 162..189
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 12..36
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 374..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 568..590
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 603..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 678..705
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 12..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 380..395
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1074 AA; 119683 MW; B00FFFEAD5130B72 CRC64;
MKDIGQQLYT THLNGGHNSL TMSPKQPDAN GAPRPNRQEA QTLLYQGSEA EAAMMTIATC
AKCKSVHKIS LQDLQKGTGK DGMYVCFQCS LGAAPPNFHF VSNNPSATHV GNKIENFSSS
INNKFKVRNF KPGKYYCDKC RFSTKDPLQY KKHTLQHEEI KFICSHCSYI SYTKGEFQRH
LVKHTGIFPY QCEYCDYGAI RNDYIVKHTK RVHERAGAKR PVKAVAKLEP KRTGTSKQNP
ELLKASNPRT TFQNKWSDQL SGFSLHANKD KMHNIMLLPE PKEYQKDVVC IPNKMTLSEP
NEVNLFENKN VEVEVLSPAK EPVQPGMPLT VVAPAELVVP ANCLAQLIDV KVVNGTQQLV
LKLFPLEENN CLEAGRDNGG NSERMVKEKG SNEQEKVLSA EKTKSLTVDR NVGKLVGIDS
FQPSVQKQLK NVKWVRSYDF IMPNSSVHNN GKSFINSETI EDFQKKNNLY PHRTAFPSVA
LKGHSLASVF KNSVLRSLGA ASNPFPYKAP VCFAENGRNL HSNSQQLLPF AASPATFSFS
GEKGLSPVSE NDLESTSKVS IPVKMVSSNR KQEDNQTEEH KAVTTVGQIS SQHKSEYLHI
NITGEDRSQQ PGDKPLELKN SERTNNTNDG PVISSVFSLS SGSENVPEGI KWNSSTSKIK
SIELLRRKIA QLIESCGKPS SLASNSAHRR SVGQASKGTS KATSEGIQEI NVSLTGPGHS
AGTLQKPPND GGITGNRQLT HQQIYPHFAD GSNRKTKSRV ARKAHVATPV LIPKGAVLRV
LNSSENAHII EATCEAPVSI PCSETQLIKP VPFCPVRQAD SDLQPLRSER GPIDMSQNIE
TPLRPKLRKE SAVCSAIHRK TGLLYGQQGS SELSKQGRLL SRSLSISRNK TKQVHLSRKK
NKIQAEPSRC LKDPSIFQVA RQLRLIAAKP DQLIKCPRRN QPVIVLNHPD VDSPEVTNVM
KVINKYKGNV LKVVLSERTR CQLGIRRHHV RLTYQNAEEA SQIKRQMMLK MKLKKVHKNN
YQVVDSLPDD SSQCVFKCWF CGRLYEDQEE WMSHGQRHLI EATRDWDVLS SKGK
//
