ID A0A2I2YDG3_GORGO Unreviewed; 415 AA.
AC A0A2I2YDG3;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Serpin family A member 5 {ECO:0000313|Ensembl:ENSGGOP00000032964.1};
GN Name=SERPINA5 {ECO:0000313|Ensembl:ENSGGOP00000032964.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000032964.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000032964.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000032964.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000032964.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the serpin family.
CC {ECO:0000256|RuleBase:RU000411}.
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DR EMBL; CABD030093897; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030093898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_018865157.1; XM_019009612.1.
DR AlphaFoldDB; A0A2I2YDG3; -.
DR STRING; 9593.ENSGGOP00000032964; -.
DR Ensembl; ENSGGOT00000043998.1; ENSGGOP00000032964.1; ENSGGOG00000001864.3.
DR GeneTree; ENSGT00940000162217; -.
DR InParanoid; A0A2I2YDG3; -.
DR OMA; QVPMMNR; -.
DR OrthoDB; 3218836at2759; -.
DR Proteomes; UP000001519; Chromosome 14.
DR Bgee; ENSGGOG00000001864; Expressed in testis and 5 other cell types or tissues.
DR GO; GO:0002080; C:acrosomal membrane; IEA:Ensembl.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0070062; C:extracellular exosome; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0031091; C:platelet alpha granule; IEA:Ensembl.
DR GO; GO:0031094; C:platelet dense tubular network; IEA:Ensembl.
DR GO; GO:0097181; C:protein C inhibitor-coagulation factor V complex; IEA:Ensembl.
DR GO; GO:0097182; C:protein C inhibitor-coagulation factor Xa complex; IEA:Ensembl.
DR GO; GO:0097183; C:protein C inhibitor-coagulation factor XI complex; IEA:Ensembl.
DR GO; GO:0036029; C:protein C inhibitor-KLK3 complex; IEA:Ensembl.
DR GO; GO:0036030; C:protein C inhibitor-plasma kallikrein complex; IEA:Ensembl.
DR GO; GO:0036026; C:protein C inhibitor-PLAT complex; IEA:Ensembl.
DR GO; GO:0036027; C:protein C inhibitor-PLAU complex; IEA:Ensembl.
DR GO; GO:0036028; C:protein C inhibitor-thrombin complex; IEA:Ensembl.
DR GO; GO:0036025; C:protein C inhibitor-TMPRSS11E complex; IEA:Ensembl.
DR GO; GO:0036024; C:protein C inhibitor-TMPRSS7 complex; IEA:Ensembl.
DR GO; GO:0032190; F:acrosin binding; IEA:Ensembl.
DR GO; GO:0031210; F:phosphatidylcholine binding; IEA:Ensembl.
DR GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR GO; GO:0001972; F:retinoic acid binding; IEA:Ensembl.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IBA:GO_Central.
DR GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
DR CDD; cd19553; serpinA5_PCI; 1.
DR Gene3D; 2.30.39.10; Alpha-1-antitrypsin, domain 1; 1.
DR Gene3D; 3.30.497.10; Antithrombin, subunit I, domain 2; 1.
DR InterPro; IPR023795; Serpin_CS.
DR InterPro; IPR023796; Serpin_dom.
DR InterPro; IPR000215; Serpin_fam.
DR InterPro; IPR036186; Serpin_sf.
DR InterPro; IPR042178; Serpin_sf_1.
DR InterPro; IPR042185; Serpin_sf_2.
DR PANTHER; PTHR11461:SF274; PLASMA SERINE PROTEASE INHIBITOR; 1.
DR PANTHER; PTHR11461; SERINE PROTEASE INHIBITOR, SERPIN; 1.
DR Pfam; PF00079; Serpin; 1.
DR SMART; SM00093; SERPIN; 1.
DR SUPFAM; SSF56574; Serpins; 1.
DR PROSITE; PS00284; SERPIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..28
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 29..415
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014133891"
FT DOMAIN 59..415
FT /note="Serpin"
FT /evidence="ECO:0000259|SMART:SM00093"
SQ SEQUENCE 415 AA; 46789 MW; 6800D5E904CD9C2D CRC64;
MPEEQRTAAM QLFLLLCLVL LSPQGASLHR HHPREMKKRV EDLHVGATVA PSSRRDFTFD
LYRALASAAP SQNIFFSPVS ISMSLAMLSL GAGSSTKMQI LEGLGLNLQK SSEEELHRGF
QQLLQELNQP RDDFQLSLGN ALFTDLVVDL QDTFVSAMKT LYLADTFPTN FRDSAGAMKQ
INDYVAKQTK GKIVDLLKNL DSNAVVIVVN YIFFKAKWET SFNHKGTQEQ DFYVTSETVV
RVPMMSREDQ YHYLLDRNLS CRVVGVPYQG NATALFILPS EGKMQQVENG LSEKTLRKWL
KMFKKRQLEL YLPKFSIEGS YQLEKVLPNL GISNVFTSRA DLSGISNHSN IQVSEMVHKA
VVEVDESGTR AAAATGTIFT FRSARLNSQR IVFNRPFLMF IVDNNILFLG KVNRP
//
