ID A0A2I2YJ10_GORGO Unreviewed; 993 AA.
AC A0A2I2YJ10;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=GTPase activating Rap/RanGAP domain like 3 {ECO:0000313|Ensembl:ENSGGOP00000034922.1};
GN Name=GARNL3 {ECO:0000313|Ensembl:ENSGGOP00000034922.1};
OS Gorilla gorilla gorilla (Western lowland gorilla).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Gorilla.
OX NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000034922.1, ECO:0000313|Proteomes:UP000001519};
RN [1] {ECO:0000313|Ensembl:ENSGGOP00000034922.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Scally A.;
RT "Insights into the evolution of the great apes provided by the gorilla
RT genome.";
RL Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSGGOP00000034922.1, ECO:0000313|Proteomes:UP000001519}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=22398555; DOI=10.1038/nature10842;
RA Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C., Xue Y.,
RA Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V., Beal K.,
RA Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A., Gu Y.,
RA Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K., Lunter G.,
RA Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D., Phillips A.D.,
RA Prado-Martinez J., Rogers A.S., Sajjadian S., Schmidt D., Shaw K.,
RA Simpson J.T., Stenson P.D., Turner D.J., Vigilant L., Vilella A.J.,
RA Whitener W., Zhu B., Cooper D.N., de Jong P., Dermitzakis E.T.,
RA Eichler E.E., Flicek P., Goldman N., Mundy N.I., Ning Z., Odom D.T.,
RA Ponting C.P., Quail M.A., Ryder O.A., Searle S.M., Warren W.C.,
RA Wilson R.K., Schierup M.H., Rogers J., Tyler-Smith C., Durbin R.;
RT "Insights into hominid evolution from the gorilla genome sequence.";
RL Nature 483:169-175(2012).
RN [3] {ECO:0000313|Ensembl:ENSGGOP00000034922.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; CABD030066834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030066835; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030066836; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030066837; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030066838; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CABD030066839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A2I2YJ10; -.
DR Ensembl; ENSGGOT00000066120.1; ENSGGOP00000034922.1; ENSGGOG00000012871.3.
DR GeneTree; ENSGT00940000159362; -.
DR Proteomes; UP000001519; Chromosome 9.
DR Bgee; ENSGGOG00000012871; Expressed in cerebellum and 5 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR001180; CNH_dom.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR PANTHER; PTHR15711:SF62; GTPASE-ACTIVATING RAP_RAN-GAP DOMAIN-LIKE PROTEIN 3; 1.
DR PANTHER; PTHR15711; RAP GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00780; CNH; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50219; CNH; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468, ECO:0000256|PROSITE-
KW ProRule:PRU00165}; Reference proteome {ECO:0000313|Proteomes:UP000001519}.
FT DOMAIN 171..387
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT DOMAIN 469..780
FT /note="CNH"
FT /evidence="ECO:0000259|PROSITE:PS50219"
FT REGION 790..822
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 893..993
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 790..809
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 893..922
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 927..960
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 993 AA; 110747 MW; ECB9EB4E8F034EBC CRC64;
MVVDFCRRFV ARSLCIILMK HFCSSSVSED LGCRRGDFSR KHYGSVELLI SSDADGAIQR
AGRFRVENGS SDENATALPG TWRRTDVHLE NPEYHTRWYF KYFLGQGNYK GYSKWKLVET
SHFRNTNIRA FHFKVSSKLC RLKDSIQSLS PKSFCSYAMN LDKFEKGPRE IFHPEIQKGS
VNFKFGVLFA KDGQLTDDEM FSNEIGSEPF QKFLNLLGDT ITLKGWTGYR GGLDTKNDTT
GIHSVYTVYQ GHEIMFHVST MLPYSKENKQ QVERKRHIGN DIVTIVFQEG EESSPAFKPS
MIRSHFTHIF ALVRYNQQND NYRLKIFSEE SVPLFGPPLP TPPVFTDHQE FRDFLLVKLI
NGEKATLETP TFAQKRRRTL DMLIRSLHQD LMPDLHKNML NRRSFSDVLP ESPKSARKKE
EARQAEFVRI GQALKLKSIV RGDAPSSLAA SGICKKEPWE PQCFCSNFPH EAVCADPWGQ
ALLVSTDAGV LLVDDDLPSV PVFDRTLPVK QMHVLETLDL LVLRADKGKD ARLFVFRLSA
LQKGLEGKQA GKNRSDCREN KLEKTKGCHL YAINTHHSRE LRIVVAIRNK LLLITRKHNK
PSGVTSTSLL SPLSESPVEE FQYIREICLS DSPMVMTLVD GPAEESDNLI CVAYRHQFDV
VNESTGEAFR LHHVEANRVN FVAAIDVYED GEAGLLLCYN YSCIYKKVCP FNGGSFLVQP
SASDFQFCWN QAPYAIVCAF PYLLAFTTDS MEIRLVVNGN LVHTAVVPQL QLVASRSDIY
FTATAAVNEV SSGGSSKGAS ARNSPQTPPG RDTPVFPSSL GEGEIQSKNL YKIPLRNLVG
RSIERPLKSP LVSKVITPPT PISVGLAAIP VTHSLSLSRM EIKEIASRTR RELLGLSDEG
GPKSEGAPKA KSKPRKRLEE SQGGPKPGAV RSSSSDRIPS GSLESASTSE ANPEGHSTSS
DQDPVADREG SPVSGSSPFQ LTAFSDEDII DLK
//
