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Database: UniProt
Entry: A0A2I2YJI2_GORGO
LinkDB: A0A2I2YJI2_GORGO
Original site: A0A2I2YJI2_GORGO 
ID   A0A2I2YJI2_GORGO        Unreviewed;      1393 AA.
AC   A0A2I2YJI2;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   05-JUN-2019, entry version 10.
DE   SubName: Full=ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 {ECO:0000313|Ensembl:ENSGGOP00000035106};
GN   Name=ARAP1 {ECO:0000313|Ensembl:ENSGGOP00000035106};
OS   Gorilla gorilla gorilla (Western lowland gorilla).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Gorilla.
OX   NCBI_TaxID=9595 {ECO:0000313|Ensembl:ENSGGOP00000035106, ECO:0000313|Proteomes:UP000001519};
RN   [1] {ECO:0000313|Ensembl:ENSGGOP00000035106, ECO:0000313|Proteomes:UP000001519}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Scally A.;
RT   "Insights into the evolution of the great apes provided by the gorilla
RT   genome.";
RL   Submitted (MAY-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSGGOP00000035106}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=22398555; DOI=10.1038/nature10842;
RA   Scally A., Dutheil J.Y., Hillier L.W., Jordan G.E., Goodhead I.,
RA   Herrero J., Hobolth A., Lappalainen T., Mailund T., Marques-Bonet T.,
RA   McCarthy S., Montgomery S.H., Schwalie P.C., Tang Y.A., Ward M.C.,
RA   Xue Y., Yngvadottir B., Alkan C., Andersen L.N., Ayub Q., Ball E.V.,
RA   Beal K., Bradley B.J., Chen Y., Clee C.M., Fitzgerald S., Graves T.A.,
RA   Gu Y., Heath P., Heger A., Karakoc E., Kolb-Kokocinski A., Laird G.K.,
RA   Lunter G., Meader S., Mort M., Mullikin J.C., Munch K., O'Connor T.D.,
RA   Phillips A.D., Prado-Martinez J., Rogers A.S., Sajjadian S.,
RA   Schmidt D., Shaw K., Simpson J.T., Stenson P.D., Turner D.J.,
RA   Vigilant L., Vilella A.J., Whitener W., Zhu B., Cooper D.N.,
RA   de Jong P., Dermitzakis E.T., Eichler E.E., Flicek P., Goldman N.,
RA   Mundy N.I., Ning Z., Odom D.T., Ponting C.P., Quail M.A., Ryder O.A.,
RA   Searle S.M., Warren W.C., Wilson R.K., Schierup M.H., Rogers J.,
RA   Tyler-Smith C., Durbin R.;
RT   "Insights into hominid evolution from the gorilla genome sequence.";
RL   Nature 483:169-175(2012).
RN   [3] {ECO:0000313|Ensembl:ENSGGOP00000035106}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JAN-2018) to UniProtKB.
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DR   EMBL; CABD030080117; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030080118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030080119; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030080120; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABD030080121; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSGGOT00000050924; ENSGGOP00000035106; ENSGGOG00000007805.
DR   GeneTree; ENSGT00940000157424; -.
DR   Proteomes; UP000001519; Chromosome 11.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd04385; RhoGAP_ARAP; 1.
DR   Gene3D; 1.10.150.50; -; 1.
DR   Gene3D; 1.10.555.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 4.
DR   Gene3D; 3.30.40.160; -; 1.
DR   InterPro; IPR037278; ARFGAP/RecO.
DR   InterPro; IPR001164; ArfGAP_dom.
DR   InterPro; IPR038508; ArfGAP_dom_sf.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR000159; RA_dom.
DR   InterPro; IPR008936; Rho_GTPase_activation_prot.
DR   InterPro; IPR037858; RhoGAP_ARAP.
DR   InterPro; IPR000198; RhoGAP_dom.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   Pfam; PF01412; ArfGap; 1.
DR   Pfam; PF00169; PH; 3.
DR   Pfam; PF00788; RA; 1.
DR   Pfam; PF00620; RhoGAP; 1.
DR   Pfam; PF00536; SAM_1; 1.
DR   PRINTS; PR00405; REVINTRACTNG.
DR   SMART; SM00105; ArfGap; 1.
DR   SMART; SM00233; PH; 5.
DR   SMART; SM00324; RhoGAP; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF47769; SSF47769; 1.
DR   SUPFAM; SSF48350; SSF48350; 1.
DR   SUPFAM; SSF57863; SSF57863; 1.
DR   PROSITE; PS50115; ARFGAP; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 4.
DR   PROSITE; PS50200; RA; 1.
DR   PROSITE; PS50238; RHOGAP; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001519};
KW   GTPase activation {ECO:0000256|SAAS:SAAS01175775};
KW   Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001519};
KW   Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW   Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT   DOMAIN       10     64       SAM. {ECO:0000259|PROSITE:PS50105}.
FT   DOMAIN      270    362       PH. {ECO:0000259|PROSITE:PS50003}.
FT   DOMAIN      383    472       PH. {ECO:0000259|PROSITE:PS50003}.
FT   DOMAIN      478    603       Arf-GAP. {ECO:0000259|PROSITE:PS50115}.
FT   DOMAIN      686    793       PH. {ECO:0000259|PROSITE:PS50003}.
FT   DOMAIN      897   1082       Rho-GAP. {ECO:0000259|PROSITE:PS50238}.
FT   DOMAIN     1115   1204       Ras-associating. {ECO:0000259|PROSITE:
FT                                PS50200}.
FT   DOMAIN     1217   1339       PH. {ECO:0000259|PROSITE:PS50003}.
FT   REGION       68    245       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2I2YJI2}.
FT   COMPBIAS     70     98       Pro-rich. {ECO:0000256|MobiDB-lite:
FT                                A0A2I2YJI2}.
FT   COMPBIAS    153    168       Pro-rich. {ECO:0000256|MobiDB-lite:
FT                                A0A2I2YJI2}.
FT   COMPBIAS    216    230       Acidic. {ECO:0000256|MobiDB-lite:
FT                                A0A2I2YJI2}.
SQ   SEQUENCE   1393 AA;  155976 MW;  1DDC80899E28F99A CRC64;
     MAEAGDAVLS VAEWLRALHL EQYTGLFEQH GLVWATECQG LNDARLMDMG MLLPGHRRRI
     LAGLLRAHTP PAPAPRPTPR PRHIFRSPPV PATPPEPLPT TTEDEGLPAA PPIPPRRSCL
     PPTCFATPST AAPDPVLPPL PAKRHLAELS VPPVPPRTGP PRPPTPLSPD DSDYDEVPEE
     GPGAPARVMT KKEEPPPSRV PRAVRVASLL SEGEELSGDD QGDEEEDDHA YEGVPNGGWH
     TSSLSLSLPS TIAAPHPMDG PPGGSTPVTP VIKAGWLDKN PPQGSYIYQK RWVRLDTDHL
     RYFDSNKDAY SKRFISVACI SHVAAIGDQK FEVITNNRTF AFRAESDVER KEWMQALQQA
     MAEQRARARL SSAYLLGVPG SEQPDRAGSL ELRGFKNKLY VAVVGDKVQL YKNLEEYHLG
     IGITFIDMSV GNVKEVDRRS FDLTTPYRIF SFSADSELEK EQWLEAMQGA IAEALSTSEV
     AERIWAAAPN RFCADCGAPQ PDWASINLCV VICKRCAGEH RGLGAGVSKV RSLKMDRKVW
     TETLIELFLQ LGNGAGNRFW AANVPPSEAL QPSSSPSTRR CHLEAKYREG KYRRYHPLFG
     NQEELDKALC AAVTTTDLAE TQALLGCGAG INCFSGDPEA PTPLALAEQA GQTLQMEFLR
     NNRTTEVPRL DSMKPLEKHY SVVLPTVSHS GFLYKTASAG KLLQDRRARE EFSRRWCVLG
     DGVLSYFENE RAVTPNGEIR ASEIVCLAVP PPDTHGFEHT FEVYTEGERL YLFGLESTEQ
     AHEWVKCIAK AFVPPLAEDL LARDFERLGR LPYKAGLSLQ RAQEGWFSLS GSELRAVFPE
     GPCEEPLQLR KLQELSIQGD SENQVLVLVE RRRTLYIQGE RRLDFMGWLG AIQKAAASMG
     DTLSEQQLGD SDIPVIVYRC VDYITQCGLT SEGIYRKCGQ TSKTQRLLES LRQDARSVHL
     KEGEQHVDDV SSALKRFLRD LPDGLFTRAQ RLAWLEASEI EDEEEKVSRY RELLVRLPPV
     NRATVKALIS HLYCVQCFSD TNQMNVHNLA IVFGPTLFQT DGQDYKAGRV VEDLINHYVV
     VFSVDEEELR KQREEITAIV KMRVAGTASG TQHAGDFICT VYLEEKKAET EQHIKIPASM
     TAEELTLEIL DRRNVGIREK DYWTCFEVNE REEAERPLHF AEKVLPILHG LGTDSHLVVK
     KHQAMEAMLL YLASRVGDTK HGMMKFREDR SLLGLGLPSG GFHDRYFILN SSCLRLYKEV
     RSQRPWSGAP ETSHRPEKEW PVKSLKVYLG VKKKLRPPTC WGFTVVHETE KHEKQQWYLC
     CDTQMELREW FATFLFVQHD GLVWPSEPSR VSRAVPEVRL GSVSLIPLRG SENEMRRSVA
     AFTADPLSLL RNV
//
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